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Metabonomics study of urine from Sprague–Dawley rats exposed to Huang-yao-zi using 1H NMR spectroscopy

Liu, Yanru, Huang, Rongqing, Liu, Lijun, Peng, Jiangnan, Xiao, Bingkun, Yang, Jianyun, Miao, Zhenchun, Huang, Honglin·2010·Journal of Pharmaceutical and Biomedical Analysis
DOI 10.1016/j.jpba.2009.12.026
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Abstract

Urinary metabolic perturbations associated with liver toxicity induced by Huang-yao-zi (root of Dioscorea bulifera L.) were studied using nuclear magnetic resonance spectroscopy ((1)H NMR) to determine the correlations between metabonomic profiling and histopathologic/biochemical observations and to discover biomarkers for liver toxicity. Huang-yao-zi with a maximal tolerance dose (MTD) was given to male Sprague-Dawley rats for 72h followed by metabonomic analysis of urine samples collected at 24 and 72h. The results revealed that the levels of taurine, creatine, betaine, dimethylglycine (DMG), acetate, glycine were elevated, whereas, the levels of succinate, 2-oxoglutarate, citrate, hippurate and urea were reduced. Partial least square (PLS)-discrimination analysis (DA) of NMR spectra revealed two apparent clusters between control groups and treatment groups, indicating metabolic changes observed in urine samples in response to Huang-yao-zi treatment. In addition, mechanism associated with oxidative injury of hepatic mitochondria was investigated. These results indicated that (1)H NMR-based metabonomics analysis in urine samples may be useful for predicting hepatotoxicity induced by Huang-yao-zi.

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Metadata

Authors
Liu, Y., Huang, R., Liu, L., Peng, J., Xiao, B., Yang, J., Miao, Z., & Huang, H.
Venue
Journal of Pharmaceutical and Biomedical Analysis
Publisher
Elsevier BV
Published
2010-05
Volume
52
Issue
1
Pages
136-141
ISSN
0731-7085
DOI
10.1016/j.jpba.2009.12.026
Cited by
60
References
1
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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