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Cited by 142Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on BehaviorPrenatal Substance Exposure Effects

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Interaction of Dopamine Transporter Genotype with Prenatal Smoke Exposure on ADHD Symptoms

Becker, Katja, El-Faddagh, Mahha, Schmidt, Martin H., Esser, Günter, Laucht, Manfred·2008·The Journal of Pediatrics
DOI 10.1016/j.jpeds.2007.07.004
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Abstract

Objective To demonstrate that children homozygous for the 10-repeat allele of the common dopamine transporter (DAT1) polymorphism who were exposed to maternal prenatal smoke exhibited significantly higher hyperactivity-impulsivity than children without these environmental or genetic risks.Study design We performed a prospective longitudinal study from birth into early adulthood monitoring the long-term outcome of early risk factors. Maternal prenatal smoking was determined during a standardized interview with the mother when the child was 3 months old. At age 15 years, 305 adolescents participated in genotyping for the DAT1 40 base pair variable number of tandem repeats polymorphism and assessment of inattention, hyperactivity-impulsivity, and oppositional defiant/conduct disorder symptoms with the Kiddie-Sads-Present and Lifetime Version.Results There was no bivariate association between DAT1 genotype, prenatal smoke exposure and symptoms of attention deficit hyperactivity disorder. However, a significant interaction between DAT1 genotype and prenatal smoke exposure emerged (P = .012), indicating that males with prenatal smoke exposure who were homozygous for the DAT1 10r allele had higher hyperactivity-impulsivity than males from all other groups. In females, no significant main effects of DAT1 genotype or prenatal smoke exposure or interaction effects on any symptoms were evident (all P > .25).Conclusions This study provides further evidence for the multifactorial nature of attention deficit hyperactivity disorder and the importance of studying both genetic and environmental factors and their interaction.

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Metadata

Authors
Becker, K., El-Faddagh, M., Schmidt, M. H., Esser, G., & Laucht, M.
Affiliations
  • Central Institute of Mental Health (DE)
  • University of Potsdam (DE)
Corresponding author
Becker, Katja
ORCID
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
2008-02
Volume
152
Issue
2
Pages
263-269.e1
ISSN
0022-3476 (ISSN-L)
DOI
10.1016/j.jpeds.2007.07.004
OpenAlex
W2052135198
Cited by
142
References
39
Citations by year
2025: 1 · 2024: 2 · 2023: 9 · 2022: 2 · 2021: 1 · 2020: 5 · 2019: 7 · 2018: 3 · 2017: 9 · 2016: 5 · 2015: 8 · 2014: 9 · 2013: 15 · 2012: 9
FWCI
8.07
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
  • publish.UP (University of Potsdam) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords
dopamine transporter gene, DAT1 polymorphism, maternal smoking, maternal smoking exposure, attention deficit hyperactivity disorder, hyperactivity/impulsivity, gene-environment interaction, genetic susceptibility, sex differences
MeSH terms
Adolescent, Alleles, Attention Deficit Disorder with Hyperactivity, Child, Child, Preschool, Environment, Female, Genotype, Homozygote, Humans, Male, Models, Genetic, Polymorphism, Genetic, Pregnancy, Prenatal Exposure Delayed Effects, Regression Analysis, Tobacco Smoke Pollution, Dopamine Plasma Membrane Transport Proteins

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