Which comes first? The obesity or the insulin? The behavior or the biochemistry?
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Insulin resistance may occur to a greater degree in the liver than in WAT in metabolic disease, thus perpetuating hepatic lipogenesis, hypertriglyceridemia, and excessive fat deposition in WAT, exacerbated by exaggerated LPL activity induced by hyperinsulinemia.
“This is particularly relevant when considering that insulin resistance may occur to a greater degree in the liver than in WAT in metabolic disease [268], thus perpetuating hepatic lipogenesis, hypertriglyceridemia, and excessive fat deposition in WAT, exacerbated by exaggerated LPL activity induced by hyperinsulinemia.”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [268]
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Experimental — accuracy not yet measuredHyperinsulinemia has been proposed to be an early crucial driver in the progression of adiposity.
“In this regard, hyperinsulinemia has been proposed to be an early crucial driver in the progression of adiposity [265,266,267,268].”
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References 9 · Cited by 36
Research works printed but not linked: 1
- August GP, Caprio S, Fennoy IL, Freemark MC, Kaufman FR, Lustig RH, et al. Prevention and treatment of pediatric obesity: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. In press, 2008.
- Authors
- Lustig, R. H.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Lustig, Robert H.
- ORCID
- Lustig, Robert H.
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 152
- Issue
- 5
- Pages
- 601-602
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W2066992761
- Cited by
- 36
- References
- 9
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 2 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 3
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- obesity, insulin, energy balance, leptin, hypothalamus, sympathetic nervous system, resting energy expenditure, fidgeting, mitochondrial efficiency, adipose tissue, childhood obesity, energy homeostasis
- MeSH terms
- Child, Feeding Behavior, Humans, Insulin Resistance, Obesity, Leptin
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