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Cited by 89Celiac Disease Research and ManagementThyroid Disorders and TreatmentsEosinophilic Esophagitis

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Prevalence of Autoimmune Thyroiditis in Children with Celiac Disease and Effect of Gluten Withdrawal

Meloni, Antonella, Mandas, Chiara, Jores, Rita Désirée, Congia, Mauro·2009·The Journal of Pediatrics
DOI 10.1016/j.jpeds.2009.01.013
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Abstract

Objective To study the prevalence of autoimmune thyroiditis (AT) in Sardinian children with celiac disease (CD) and the effects of a gluten-free diet (GFD) on thyroid function. Study design Children with biopsy-proven CD (n = 324; female:male 2:1; mean age, 6.6 years) followed from 1 to 15 years, were retrospectively evaluated for AT at onset of CD and during GFD. Serum thyroid peroxidase and thyroglobulin antibodies (AbTPO, AbTG), thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), and thyroid ultrasonography were considered. Age-matched Sardinian schoolchildren (n = 8040), previously evaluated for antithyroid antibodies and thyroid function, were used as controls. Results Thirty-four patients with CD (10.5%) developed AT (female:male 4,5:1; mean age, 10.5 years), 11 at onset of CD and 23 during GFD, with a higher prevalence than controls (P = 2.9(-13)). Twenty-eight patients were euthyroid and 6 hypothyroid. AbTPO and/or AbTG persisted elevated for 2 to 9 years despite the GFD in 9 of 11 patients with AT at onset of CD. Conclusions AT is strongly associated with CD in Sardinian children, has an age of onset of 10.5 years, and appears to be gluten-independent. In children with CD with AT, the female:male bias reported in adult AT is present before puberty.

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Metadata

Authors
Meloni, A., Mandas, C., Jores, R. D., & Congia, M.
Affiliations
University of Cagliari (IT)
Corresponding author
Meloni, Antonella
ORCID
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
2009-07
Volume
155
Issue
1
Pages
51-55.e1
ISSN
0022-3476 (ISSN-L)
DOI
10.1016/j.jpeds.2009.01.013
OpenAlex
W1964219283
Cited by
89
References
0
Citations by year
2026: 2 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 5 · 2021: 7 · 2020: 6 · 2019: 2 · 2018: 8 · 2017: 3 · 2016: 4 · 2015: 7 · 2014: 3 · 2013: 8 · 2012: 6
FWCI
5.67
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Gastroenterology › Eosinophilic Esophagitis
Keywords
autoimmune thyroiditis, celiac disease, gluten-free diet, gluten withdrawal, thyroid peroxidase antibodies, thyroglobulin antibodies, hypothyroidism, thyroid function, prevalence, sex differences, children, Sardinia
MeSH terms
Adolescent, Autoantibodies, Celiac Disease, Child, Child, Preschool, Female, Humans, Hypothyroidism, Infant, Iodide Peroxidase, Italy, Male, Puberty, Retrospective Studies, Sex Factors, Thyroglobulin, Thyroiditis, Autoimmune, Prevalence, Case-Control Studies, Diet, Gluten-Free

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Meloni, A., Mandas, C., Jores, R. D., & Congia, M. (2009). Prevalence of Autoimmune Thyroiditis in Children with Celiac Disease and Effect of Gluten Withdrawal. The Journal of Pediatrics. https://doi.org/10.1016/j.jpeds.2009.01.013