Prevalence of Nocturnal Hypoglycemia in Pediatric Type 1 Diabetes: A Pilot Study Using Continuous Glucose Monitoring
Abstract
Objectives To determine the prevalence of nocturnal hypoglycemia (NH) in pediatric type 1 diabetes, to compare the prevalence of NH detected by continuous glucose monitoring (CGM) and self-monitored blood glucose (SMBG), and to compare the prevalence of NH using different thresholds. Study design Twenty-five patients wore a continuous glucose monitor for 3 nights and also conducted SMBG. NH was defined with three thresholds: (1) Results The prevalence of NH with CGM was 68%, 52%, and 48% with the different thresholds. Of the 35 episodes of NH detected by CGM, 25 were not symptomatic and therefore not detected by SMBG. The mean difference in blood glucose between CGM and SMBG was -0.18 mmol/L (P = .35). Conclusions This pilot study suggests that the prevalence of NH in pediatric patients with type 1 diabetes with conventional treatment may be as high as 68%, although this varied according to the method of detection and threshold used. Patients may benefit from CGM to detect asymptomatic NH.
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Continuous glucose monitoring is most appropriate for highly motivated patients with type 1 diabetes who are willing to wear the monitoring device, and those with continuous poor control during intensive insulin therapy.
“Therefore, continuous glucose monitoring is most appropriate for highly motivated patients with type 1 diabetes who are willing to wear the monitoring device, and those with continuous poor control during intensive insulin therapy.93”
From Type 1 diabetes (2014) · cites this paper as [93]
Cites
Epidemiology of severe hypoglycemia in the diabetes control and complications trial
(1991) · The American Journal of Medicine · doi:10.1016/0002-9343(91)80085-z · Cited by 807 · see citing works
Davis, E. A., Keating, B., Byrne, G. C., Russell, M., & Jones, T. W. (1997) · Diabetes Care · doi:10.2337/diacare.20.1.22 · Cited by 273 · see citing works
Beregszàszi, M., Tubiana-Rufi, N., Benali, K., Noël, M., Bloch, J., & Czernichow, P. (1997) · The Journal of Pediatrics · doi:10.1016/s0022-3476(97)70121-5 · Cited by 122 · see citing works
Amin, R., Ross, K., Acerini, C. L., Edge, J. A., Warner, J., & Dunger, D. B. (2003) · Diabetes Care · doi:10.2337/diacare.26.3.662 · Cited by 106 · see citing works
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Atkinson, M. A., Eisenbarth, G. S., & Michels, A. W. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60591-7 · Cited by 2,713 · see citing works
- Authors
- Ahmet, A., Dagenais, S., Barrowman, N. J., Collins, C. J., & Lawson, M. L.
- Affiliations
- University of Ottawa (CA)
- Corresponding author
- Ahmet, Alexandra
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 159
- Issue
- 2
- Pages
- 297-302.e1
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W1976496039
- Cited by
- 42
- References
- 4
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 5 · 2015: 1 · 2014: 2 · 2013: 9 · 2012: 5
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- nocturnal hypoglycemia, type 1 diabetes in children, continuous glucose monitoring, self-monitoring of blood glucose, asymptomatic hypoglycemia, hypoglycemia prevalence
- MeSH terms
- Blood Glucose, Child, Circadian Rhythm, Diabetes Mellitus, Type 1, Female, Follow-Up Studies, Humans, Hypoglycemia, Male, Ontario, Pilot Projects, Risk Factors, Blood Glucose Self-Monitoring, Prevalence
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