Vitamin D status is linked to biomarkers of oxidative stress, inflammation, and endothelial activation in obese children
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Objective To examine vitamin D, parathyroid hormone, and serum calcium-phosphorus levels relationships to biomarkers of oxidative/nitrosative stress, inflammation, and endothelial activation, potential contributors for vascular complications in obese children.Study design Cross-sectional clinical study of 66 obese Caucasian children aged 7 to 14 years. Cardiovascular risk factors were assessed. Malondialdehyde and myeloperoxidase as measures of oxidative stress, and plasma nitrite+nitrate, urinary nitrate, and 3-nitrotyrosine as markers of nitrosative stress were measured. Adipocytokines, inflammatory molecules (high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-α), endothelial activation molecules (soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule 1 [sVCAM-1]), E-selectin, and vascular endothelial growth factor were also investigated. Serum 25-hydroxy-cholecalciferol [25(OH)D], intact parathormone, and calcium-phosphorus levels were determined in these children and in a comparison group of 39 non-obese children.Results Obese children had a significantly lower 25(OH)D level (P = .002) and a higher intact parathormone (P = .011) than non-obese children. Phosphorus and the calcium-phosphorus product were also significantly higher (P < .0001). Insufficient serum concentrations of 25(OH)D (<20 ng/mL) were detected in 5% of normal children and in 30% of the obese children. In the obese children with vitamin D insufficiency, malondialdehyde, myeloperoxidase, 3-nitrotyrosine, interleukin-6, and sVCAM-1 were substantially elevated. A partial correlation analysis showed an inverse relationship of 25(OH)D levels with 3-nitrotyrosine (r = -0.424, P = .001), and sVCAM-1 (r = -0.272, P = .032).Conclusions Insufficient 25(OH)D levels were detected in severely obese children with increased markers of oxidative/nitrosative stress, inflammation, and endothelial activation.
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Low vitamin D status is associated with increased inflammatory, oxidative, and endothelial activation biomarkers in obese individuals.
“Evidence shows that 25(OH)D concentrations correlate significantly positively with glutathione levels in healthy adult populations [154], and low vitamin D status is associated with increased inflammatory, oxidative and endothelial activation biomarkers in obese individuals [155].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [155]
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References 31 · Cited by 135
- Authors
- Codoñer-Franch, P., Tavárez-Alonso, S., Simó-Jordá, R., Laporta-Martín, P., Carratalá-Calvo, A., & Alonso-Iglesias, E.
- Affiliations
- Universitat de València (ES)
- Hospital Clínico Universitario de Valencia (ES)
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 161
- Issue
- 5
- Pages
- 848-854
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W2004309571
- Cited by
- 135
- References
- 31
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 9 · 2023: 18 · 2022: 10 · 2021: 9 · 2020: 7 · 2019: 10 · 2018: 11 · 2017: 11 · 2016: 14 · 2015: 15 · 2014: 13 · 2013: 5
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- vitamin D deficiency, childhood obesity, oxidative stress, nitrosative stress, endothelial activation, inflammation, malondialdehyde, myeloperoxidase, nitrotyrosine, soluble VCAM-1, parathyroid hormone, calcium and phosphorus metabolism, adipokines, C-reactive protein, interleukin-6, TNF-α, endothelial dysfunction
- MeSH terms
- Adolescent, Calcium, Cardiovascular Diseases, Child, Cross-Sectional Studies, Endothelium, Vascular, Female, Humans, Inflammation, Male, Nitrogen, Obesity, Parathyroid Hormone, Phosphorus, Risk Factors, Vitamin D, Biomarkers, Oxidative Stress
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