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Increasing Prevalence of Nonalcoholic Fatty Liver Disease Among United States Adolescents, 1988-1994 to 2007-2010
Open accessAbstract
Objective To assess recent trends in nonalcoholic fatty liver disease (NAFLD) prevalence among US adolescents. Study design Cross-sectional data from 12 714 12–19 year olds (exclusions: chronic hepatitis, hepatotoxic medications) in the National Health and Examination Survey between 1988–1994 and 2007–2010 were used to estimate trends in suspected NAFLD, defined as overweight (body mass index ≥85th percentile) plus elevated alanine aminotransferase levels (boys >25.8 U/L; girls >22.1 U/L). Linear trends in prevalence and the independent effect of demographic indicators and adiposity on NAFLD risk were tested using regression models. Complex sampling methods and P values of <.05 were used to assess statistical significance. Results Suspected NAFLD prevalence (SE) rose from 3.9% (0.5) in 1988–1994 to 10.7% (0.9) in 2007–2010 (P < .0001), with increases among all race/ethnic subgroups, males and females, and those obese (P trend ≤.0006 for all). Among those obese, the multivariate adjusted odds of suspected NAFLD were higher with increased age, body mass index, Mexican American race, and male sex; the adjusted odds in 2007–2010 were 2.0 times those in 1988–1994. In 2007–2010, 48.1% (3.7) of all obese males and 56.0% (3.5) of obese Mexican American males had suspected NAFLD. Conclusion Prevalence of suspected NAFLD has more than doubled over the past 20 years and currently affects nearly 11% of adolescents and one-half of obese males. The rapid increase among those obese, independent of body mass index, suggests that other modifiable risk factors have influenced this trend.
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Metadata
- Authors
- Welsh, J. A., Karpen, S., & Vos, M. B.
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 162
- Issue
- 3
- Pages
- 496-500.e1
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W2090013838
- Cited by
- 482
- References
- 0
- FWCI
- 18.74
- Type
- journal article
- Language
- en
- Open access
- green
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