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Cited by 168Effects and risks of endocrine disrupting chemicalsToxic Organic Pollutants ImpactHeavy Metal Exposure and Toxicity

Urinary Phthalates Are Associated with Higher Blood Pressure in Childhood

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Trasande, Leonardo, Sathyanarayana, Sheela, Spanier, Adam J., Trachtman, Howard, Attina, Teresa M., Urbina, Elaine M.·2013·The Journal of Pediatrics
DOI 10.1016/j.jpeds.2013.03.072PMC PMC4074773
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Abstract

Objective To examine associations of urinary phthalate levels with blood pressure (BP) and serum triglyceride and lipoprotein levels in children. Study design We performed a cross-sectional analysis of a subsample of US children aged 6-19 years who participated in the National Health and Nutrition Examination Survey between 2003 and 2008. We quantified exposure to 3 families of phthalates--low molecular weight, high molecular weight and di-2-ethylhexylphthalate (DEHP)--based on molar concentration of urinary metabolites. We assessed descriptive, bivariate, and multivariate associations with BP and lipid levels. Results Controlling for an array of sociodemographic and behavioral factors, as well as diet and body mass index, levels of metabolites of DEHP, a phthalate commonly found in processed foods, were associated with higher age-, sex-, and height-standardized BP. For each log unit (roughly 3-fold) increase in DEHP metabolites, a 0.041 SD unit increase in systolic BP z-score was identified (P = .047). Metabolites of low molecular weight phthalates commonly found in cosmetics and personal care products were not associated with BP. Phthalate metabolites were not associated with triglyceride levels, high-density lipoprotein level, or prehypertension. Conclusions Dietary phthalate exposure is associated with higher systolic BP in children and adolescents. Further work is needed to confirm these associations, as well as to evaluate opportunities for intervention.

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  • Phthalate exposures have been shown to result in insulin resistance.

    “Phthalate exposures have been shown to result in insulin resistance [166,194].”

    From A Review of Biomonitoring of Phthalate Exposures (2019) · cites this paper as [194]

    The Discussion (page not provided) says DEHP metabolites may contribute to insulin resistance, but presents this as a possible mechanism requiring corroboration, not a demonstrated result. The paper studied blood pressure in children and did not establish that phthalate exposure causes insulin resistance. (LLM, conf=0.88)

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Research works printed but not linked: 43

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Authors
Trasande, L., Sathyanarayana, S., Spanier, A. J., Trachtman, H., Attina, T. M., & Urbina, E. M.
Affiliations
  • New York University (US)
  • University of Washington (US)
  • Pennsylvania State University (US)
  • Cincinnati Children's Hospital Medical Center (US)
ORCID
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
2013-09
Volume
163
Issue
3
Pages
747-753.e1
ISSN
0022-3476 (ISSN-L)
DOI
10.1016/j.jpeds.2013.03.072
PMC
PMC4074773
OpenAlex
W2067036698
Cited by
168
References
0
Citations by year
2026: 3 · 2025: 15 · 2024: 14 · 2023: 10 · 2022: 16 · 2021: 19 · 2020: 15 · 2019: 18 · 2018: 15 · 2017: 13 · 2016: 13 · 2015: 12 · 2014: 4 · 2013: 1
FWCI
6.26
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (UL1TR000077)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK100307)
  • National Center for Advancing Translational Sciences
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Keywords
phthalates, urinary phthalate metabolites, blood pressure, pediatric hypertension, systolic blood pressure, low molecular weight phthalates, high molecular weight phthalates, serum triglycerides, HDL cholesterol, prehypertension, dietary exposure, children and adolescents, endocrine disruptors
MeSH terms
Adolescent, Child, Cross-Sectional Studies, Environmental Exposure, Environmental Monitoring, Environmental Pollutants, Female, Humans, Hypertension, Lipoproteins, HDL, Male, Nutrition Surveys, Phthalic Acids, Triglycerides, United States, Biomarkers, Multivariate Analysis, Linear Models, Logistic Models, Dyslipidemias, Young Adult, Prehypertension

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