Anxiety adversely impacts response to cognitive behavioral therapy in children with chronic pain
Open accessAbstract
Objective To evaluate whether clinical anxiety in children presenting to a pediatric pain management center is associated with a poorer treatment response for those who completed pain-focused cognitive behavioral therapy (CBT).Study design The total sample consisted of 175 children, 40 of whom completed CBT for chronic pain. The Screen for Child Anxiety Related Emotional Disorders was completed at initial evaluation and outcome measures (average pain intensity and the Functional Disability Inventory) were collected during the initial evaluation and at the end of CBT. Group differences in outcomes were examined following CBT. The role of anxiety in CBT initiation and completion was also explored.Results Presence of clinical anxiety was associated with greater initiation and/or completion of pain-focused CBT but also a poorer treatment response. Specifically, the group with subclinical anxiety exhibited a substantial reduction in pain intensity, and the group with clinical anxiety exhibited a more limited response to treatment (F [1, 36] = 13.68 P < .01). A similar effect was observed for Functional Disability Inventory, such that the group with clinical anxiety had a significantly smaller response to treatment (F [1, 38] = 4.33 P < .05). The difference in pain and disability between groups following CBT suggest moderate effects (Cohen d = 0.77 and 0.78, respectively).Conclusions Although youths with clinical anxiety are more likely to start and/or complete pain-focused CBT, anxiety has an adverse impact on CBT treatment response in children with chronic pain. Identification of patients with anxiety and use of tailored behavioral interventions may improve clinical outcomes.
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The co-occurrence of chronic pain and psychiatric concerns is likely bidirectional.
“and the co-occurrence is likely bidirectional in nature. In other words, psychological symptoms could potentially be a contributing factor and an outcome of having chronic pain [33,113].”
From Best-evidence for the rehabilitation of chronic pain part 1: Pediatric pain (2019) · cites this paper as [113]
The Discussion (page not provided) reports that anxiety commonly co-occurs with chronic pain in youth and that those with clinically significant anxiety had less improvement in pain after CBT. It does not say that chronic pain can produce psychological symptoms, so it does not support the claimed bidirectional relationship. (LLM, conf=0.83)
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References 40 · Cited by 89
- Authors
- Cunningham, N. R., Jagpal, A., Tran, S. T., Kashikar-Zuck, S., Goldschneider, K. R., Coghill, R. C., & Lynch-Jordan, A. M.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- DePaul University (US)
- ORCID
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 171
- Pages
- 227-233
- ISSN
- 0022-3476 (ISSN-L)
- PMC
- PMC4808589
- OpenAlex
- W2261561069
- Cited by
- 89
- References
- 40
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 10 · 2023: 3 · 2022: 10 · 2021: 13 · 2020: 9 · 2019: 12 · 2018: 9 · 2017: 10 · 2016: 3
- FWCI
- 13.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (HD F32, K24 AR056687, 1F32HD078049 – 01A1)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Pain Management Techniques
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- anxiety, chronic pain, children, cognitive behavioral therapy, treatment response, pain intensity, functional disability, pediatric pain management, subclinical anxiety, treatment completion
- MeSH terms
- Adolescent, Anxiety, Child, Female, Hospitals, Pediatric, Humans, Male, Pain, Midwestern United States, Cognitive Behavioral Therapy, Treatment Outcome, Caregivers, Chronic Pain, Pain Management
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