Risk of Fractures in Youths with Celiac Disease—A Population-Based Study
Abstract
Objective To assess the risk of any fracture requiring hospital care in a cohort of individuals with celiac disease diagnosed in childhood/adolescence compared with reference individuals matched by age and sex. Study design Our study cohort consisted of 213 635 people born and residing in Friuli-Venezia Giulia Region, Italy, in 1989-2011. We selected, through pathology reports, hospital discharge records, or co-payment exemptions, 1233 individuals with celiac disease (aged 0-17 years at diagnosis) and compared them with 6167 reference individuals matched by sex and year of birth. Fractures were identified through hospital discharge records. We calculated hazard ratios (HRs) for any fracture after celiac disease diagnosis (or index date for reference individuals) with Cox regression and ORs for any fracture before celiac disease diagnosis with conditional logistic regression. Results During the follow-up period (maximum 23 years), 22 individuals with celiac disease (9394 person-years) and 128 reference individuals (47 308 person-years) experienced a fracture, giving an overall HR of 0.87 (95% CI 0.55-1.37). The risk was not modified by sex, age at diagnosis, or calendar period of diagnosis. We obtained similar HRs when excluding fractures occurring after the age of 18 years and adjusting for maternal education or vitamin D supplementation. The odds of previous fracture also did not differ between subjects with celiac disease and reference individuals (22 and 96 cases, respecti…
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Coeliac disease in children does not seem to be associated with an increased fracture risk.
“In contrast to that observed in adults (30), CD in children does not seem to be associated with an increased fracture risk (31).”
From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [31]
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ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease.
Mearin, M. L., Agardh, D., Antunes, H., Al‐toma, A., Auricchio, R., Castillejo, G., Catassi, C., Ciacci, C., Discepolo, V., Dolinsek, J., et al. (2022) · Journal of pediatric gastroenterology and nutrition · doi:10.1097/mpg.0000000000003540 · Cited by 186 · see citing works
- Authors
- Canova, C., Pitter, G., Zanier, L., Simonato, L., Michaelsson, K., & Ludvigsson, J. F.
- Affiliations
- University of Padua (IT)
- Regione Autonoma Friuli Venezia Giulia (IT)
- University of Nottingham (GB)
- Corresponding author
- Canova, Cristina
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 198
- Pages
- 117-120
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W2801089050
- Cited by
- 16
- References
- 0
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 2
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- University of Padua (F.S. 4.18.01.05)
- Topics
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Surgery › Gastrointestinal disorders and treatments
- Keywords
- celiac disease, fracture, fracture risk, adolescents, hospitalization, vitamin D supplementation, maternal education, bone health
- MeSH terms
- Adolescent, Celiac Disease, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Italy, Male, Risk, Cohort Studies, Logistic Models, Proportional Hazards Models, Case-Control Studies, Fractures, Bone, Young Adult
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