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Entourage effects of nonpsychotropic cannabinoids on visceral sensitivity in experimental colitis

Svendsen, Kristofer, Bradaia, Amyaouch, Gandini, Maria A., Defaye, Manon, Matisz, Chelsea, Abdullah, Nasser S., Gruber, Aaron, Zamponi, Gerald W., Sharkey, Keith A., Altier, Christophe·2025·The Journal of Pharmacology and Experimental Therapeutics

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  1. Abdullah, 2020, Neural control of gut homeostasis, Am J Physiol Gastrointest Liver Physiol, 319, G718, 10.1152/ajpgi.00293.2020 · DOI
  2. Arzamendi, 2024, Sex-specific post-inflammatory dysbiosis mediates chronic visceral pain in colitis, Gut Microbes, 16, 10.1080/19490976.2024.2409207 · DOI
  3. Bábíčková, 2015, Sex differences in experimentally induced colitis in mice: a role for estrogens, Inflammation, 38, 1996, 10.1007/s10753-015-0180-7 · DOI
  4. Booker, 2009, Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception, Drug Alcohol Depend, 105, 42, 10.1016/j.drugalcdep.2009.06.009 · DOI
  5. Borrelli, 2013, Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease, Biochem Pharmacol, 85, 1306, 10.1016/j.bcp.2013.01.017 · DOI
  6. Brierley, 2018, Spinal afferent innervation of the colon and rectum, Front Cell Neurosci, 12, 467, 10.3389/fncel.2018.00467 · DOI
  7. Brierley, 2004, Splanchnic and pelvic mechanosensory afferents signal different qualities of colonic stimuli in mice, Gastroenterology, 127, 166, 10.1053/j.gastro.2004.04.008 · DOI · Paper page
  8. Chahyadinata, 2024, Physiological profiling of cannabidiol reveals profound inhibition of sensory neurons, Pain, 165, 2544, 10.1097/j.pain.0000000000003273 · DOI
  9. Chaloner, 2013, Sexually dimorphic effects of unpredictable early life adversity on visceral pain behavior in a rodent model, J Pain, 14, 270
  10. Christianson, 2006, Differences in spinal distribution and neurochemical phenotype of colonic afferents in mouse and rat, J Comp Neurol, 494, 246, 10.1002/cne.20816 · DOI
  11. Czégény, 2021, CBD, a precursor of THC in e-cigarettes, Sci Rep, 11, 8951, 10.1038/s41598-021-88389-z · DOI
  12. De Petrocellis, 2011, Effects of cannabinoids and cannabinoid-enriched cannabis extracts on TRP channels and endocannabinoid metabolic enzymes, Br J Pharmacol, 163, 1479, 10.1111/j.1476-5381.2010.01166.x · DOI · Paper page
  13. De Petrocellis, 2012, Cannabinoid actions at TRPV channels: effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation, Acta Physiol (Oxf), 204, 255, 10.1111/j.1748-1716.2011.02338.x · DOI
  14. Defaye, 2022, Gut-innervating TRPV1+ neurons drive chronic visceral pain via microglial P2Y12 receptor, Cell Mol Gastroenterol Hepatol, 13, 977, 10.1016/j.jcmgh.2021.12.012 · DOI
  15. Defaye, 2024, Induction of antiviral interferon-stimulated genes by neuronal STING promotes the resolution of pain in mice, J Clin Invest, 134, 10.1172/JCI176474 · DOI
  16. Defaye, 2022, The neuronal tyrosine kinase receptor ligand ALKAL2 mediates persistent pain, J Clin Invest, 132, 10.1172/JCI154317 · DOI
  17. Deiana, 2012, Psychopharmacology (Berl), 219, 859, 10.1007/s00213-011-2415-0 · DOI · Paper page
  18. DeLong, 2010, Pharmacological evaluation of the natural constituent of Cannabis sativa, cannabichromene and its modulation by Δ9-tetrahydrocannabinol, Drug Alcohol Depend, 112, 126, 10.1016/j.drugalcdep.2010.05.019 · DOI · Paper page
  19. Drewes, 2020, Gastrointestinal pain, Nat Rev Dis Primers, 6, 1, 10.1038/s41572-019-0135-7 · DOI
  20. Francis-Malavé, 2023, Sex differences in pain-related behaviors and clinical progression of disease in mouse models of colonic pain, Pain, 164, 197, 10.1097/j.pain.0000000000002683 · DOI
  21. Gandini, 2019, Differential regulation of Cav2.2 channel exon 37 variants by alternatively spliced μ-opioid receptors, Mol Brain, 12, 98, 10.1186/s13041-019-0524-6 · DOI
  22. Grundy, 2019, Visceral pain, Annu Rev Physiol, 81, 261, 10.1146/annurev-physiol-020518-114525 · DOI
  23. Harding, 2023, Differential regulation of Cav 3.2 and Cav 2.2 calcium channels by CB1 receptors and cannabidiol, Br J Pharmacol, 180, 1616, 10.1111/bph.16035 · DOI
  24. Harding, 2022, Central and peripheral contributions of T-type calcium channels in pain, Mol Brain, 15, 39, 10.1186/s13041-022-00923-w · DOI
  25. Harrington, 2019, Colonic afferent input and dorsal horn neuron activation differs between the thoracolumbar and lumbosacral spinal cord, Am J Physiol Gastrointest Liver Physiol, 317, G285, 10.1152/ajpgi.00013.2019 · DOI
  26. Hockley, 2019, Single-cell RNAseq reveals seven classes of colonic sensory neuron, Gut, 68, 633, 10.1136/gutjnl-2017-315631 · DOI · Paper page
  27. Huang, 2023, Cannabidiol inhibits Nav channels through two distinct binding sites, Nat Commun, 14, 3613, 10.1038/s41467-023-39307-6 · DOI
  28. Hurtado-Lorenzo, 2021, Chronic abdominal pain in IBD research initiative: unraveling biological mechanisms and patient heterogeneity to personalize treatment and improve clinical outcomes, Crohns Colitis, 360
  29. Iannotti, 2014, Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: Potential for the treatment of neuronal hyperexcitability, ACS Chem Neurosci, 5, 1131, 10.1021/cn5000524 · DOI · Paper page
  30. Izzo, 2012, Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice, Br J Pharmacol, 166, 1444, 10.1111/j.1476-5381.2012.01879.x · DOI
  31. Jastrząb, 2022, The origin and biomedical relevance of cannabigerol, Int J Mol Sci, 23, 7929, 10.3390/ijms23147929 · DOI
  32. Ji, 2003, Estrogen modulates the visceromotor reflex and responses of spinal dorsal horn neurons to colorectal stimulation in the rat, J Neurosci, 23, 3908, 10.1523/JNEUROSCI.23-09-03908.2003 · DOI
  33. Ji, 2008, The visceromotor response to colorectal distention fluctuates with the estrous cycle in rats, Neuroscience, 154, 1562, 10.1016/j.neuroscience.2008.04.070 · DOI
  34. Lapointe, 2015, TRPV1 sensitization mediates postinflammatory visceral pain following acute colitis, Am J Physiol Gastrointest Liver Physiol, 309, G87, 10.1152/ajpgi.00421.2014 · DOI
  35. Ligresti, 2016, From phytocannabinoids to cannabinoid receptors and endocannabinoids: pleiotropic physiological and pathological roles through complex pharmacology, Physiol Rev, 96, 1593, 10.1152/physrev.00002.2016 · DOI · Paper page
  36. Marger, 2011, T-type calcium channels contribute to colonic hypersensitivity in a rat model of irritable bowel syndrome, Proc Natl Acad Sci U S A, 108, 11268, 10.1073/pnas.1100869108 · DOI
  37. Millar, 2019, A systematic review of cannabidiol dosing in clinical populations, Br J Clin Pharmacol, 85, 1888, 10.1111/bcp.14038 · DOI
  38. Mirlohi, 2022, Inhibition of human recombinant T-type calcium channels by phytocannabinoids in vitro, Br J Pharmacol, 179, 4031, 10.1111/bph.15842 · DOI
  39. Naftali, 2021, Cannabis is associated with clinical but not endoscopic remission in ulcerative colitis: a randomized controlled trial, PLoS One, 16, 10.1371/journal.pone.0246871 · DOI
  40. Naftali, 2019, Medical cannabis for inflammatory bowel disease: real-life experience of mode of consumption and assessment of side-effects, Eur J Gastroenterol Hepatol, 31, 1376, 10.1097/MEG.0000000000001565 · DOI
  41. Nyuyki, 2018, Altered brain excitability and increased anxiety in mice with experimental colitis: consideration of hyperalgesia and sex differences, Front Behav Neurosci, 12, 58, 10.3389/fnbeh.2018.00058 · DOI
  42. Pagano, 2016, An orally active Cannabis extract with high content in cannabidiol attenuates chemically-induced intestinal inflammation and hypermotility in the mouse, Front Pharmacol, 7, 1, 10.3389/fphar.2016.00341 · DOI
  43. Pagano, 2021, Efficacy of combined therapy with fish oil and phytocannabinoids in murine intestinal inflammation, Phytotherapy Research, 35, 517, 10.1002/ptr.6831 · DOI
  44. Pagano, 2019, The non-euphoric phytocannabinoid cannabidivarin counteracts intestinal inflammation in mice and cytokine expression in biopsies from UC pediatric patients, Pharmacol Res, 149, 10.1016/j.phrs.2019.104464 · DOI
  45. Pertwee, 2005, Pharmacological actions of cannabinoids, Handb Exp Pharmacol, 168, 1, 10.1007/3-540-26573-2_1 · DOI
  46. Qiao, 2020, Spinal neuron-glia-immune interaction in cross-organ sensitization, Am J Physiol Gastrointest Liver Physiol, 319, 748, 10.1152/ajpgi.00323.2020 · DOI
  47. Rock, 2011, Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews, Psychopharmacology (Berl), 215, 505, 10.1007/s00213-010-2157-4 · DOI
  48. Romano, 2013, The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis, Br J Pharmacol, 169, 213, 10.1111/bph.12120 · DOI
  49. Ross, 2008, Inhibition of recombinant human T-type calcium channels by Δ9-tetrahydrocannabinol and cannabidiol, J Biol Chem, 283, 16124, 10.1074/jbc.M707104200 · DOI
  50. Sepulveda, 2022, Cannabigerol (CBG) attenuates mechanical hypersensitivity elicited by chemotherapy-induced peripheral neuropathy, Eur J Pain, 26, 1950, 10.1002/ejp.2016 · DOI
  51. Silva, 2017, Antinociceptive effects of HUF-101, a fluorinated cannabidiol derivative, Prog Neuropsychopharmacol Biol Psychiat, 79, 369, 10.1016/j.pnpbp.2017.07.012 · DOI
  52. Silva-Cardoso, 2022, Chronic pain and cannabidiol in animal models: behavioral pharmacology and future perspectives, Cannabis Cannabinoid Res, 8, 241
  53. Stella, 2023, THC and CBD: similarities and differences between siblings, Neuron, 111, 302, 10.1016/j.neuron.2022.12.022 · DOI
  54. Storr, 2014, Cannabis use provides symptom relief in patients with inflammatory bowel disease but is associated with worse disease prognosis in patients with Crohn’s disease, Inflamm Bowel Dis, 20, 472, 10.1097/01.MIB.0000440982.79036.d6 · DOI
  55. Svendsen, 2024, Non-intoxicating cannabinoids in visceral pain, Cannabis Cannabinoid Res, 9, 3, 10.1089/can.2023.0113 · DOI
  56. Wang, 2022, Cannabidivarin alleviates neuroinflammation by targeting TLR4 co-receptor MD2 and improves morphine-mediated analgesia, Front Immunol, 13
  57. Waxman, 2014, Regulating excitability of peripheral afferents: emerging ion channel targets, Nat Neurosci, 17, 153, 10.1038/nn.3602 · DOI · Paper page
  58. Weaver, 2020, Managing pain and psychosocial care in IBD: a primer for the practicing gastroenterologist, Curr Gastroenterol Rep, 22, 20, 10.1007/s11894-020-0757-7 · DOI
  59. Zagzoog, 2020, In vitro and in vivo pharmacological activity of minor cannabinoids isolated from Cannabis sativa, Sci Rep, 10, 1, 10.1038/s41598-020-77175-y · DOI
  60. Zhang, 2021, Cannabidiol inhibition of murine primary nociceptors: tight binding to slow inactivated states of Nav1.8 channels, J Neurosci, 41, 6371, 10.1523/JNEUROSCI.3216-20.2021 · DOI
  61. Zheng, 2019, Deep sequencing of somatosensory neurons reveals molecular determinants of intrinsic physiological properties, Neuron, 103, 598, 10.1016/j.neuron.2019.05.039 · DOI · Paper page

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Metadata

Authors
Svendsen, K., Bradaia, A., Gandini, M. A., Defaye, M., Matisz, C., Abdullah, N. S., Gruber, A., Zamponi, G. W., Sharkey, K. A., & Altier, C.
Venue
The Journal of Pharmacology and Experimental Therapeutics
Publisher
Elsevier BV
Published
2025-03
Volume
392
Issue
3
Pages
103389
ISSN
0022-3565
Cited by
8
References
1
Language
en
Licence
  • www.elsevier.com/tdm/userlicense/1.0/ (tdm)
  • www.elsevier.com/legal/tdmrep-license (tdm)
Funders
  • Canadian Institutes of Health Research
  • Canadian Association of Gastroenterology
  • Alberta Innovates (G2020000218)

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