The influence of temperature on photodynamic cell killing in vitro with 5-aminolevulinic acid
Abstract
Cell survival was investigated after exposing cells in vitro to different temperatures before or after photodynamic therapy with 5-aminolevulinic acid. The photodynamic process was found to be temperature dependent. Cells exposed for 1h to 41 degrees C before light exposure or to 7 degrees C after light exposure showed decreased survival. Furthermore, the photobleaching rate of protoporphyrin IX in the cells was found to increase with increasing temperature during the light exposure. Thus, the photodynamic effect with 5-aminolevulinic acid may be enhanced by heating the tumour area before, and by cooling it immediately after the treatment.
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Influence of tissue temperature on PpIX accumulation was observed in several studies.
“For example, the influence of tissue temperature on PpIX accumulation was observed in several studies [61,62].”
From Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer (2011) · cites this paper as [62]
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References 53 · Cited by 41
- Authors
- Juzeniene, A., Juzenas, P., Bronshtein, I., Vorobey, A., & Moan, J.
- Affiliations
- Bar-Ilan University (IL)
- Institute of Biophysics and Cell Engineering (BY)
- University of Oslo (NO)
- Corresponding author
- Juzeniene, Asta
- Venue
- Journal of Photochemistry and Photobiology B: Biology
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 84
- Issue
- 2
- Pages
- 161-166
- ISSN
- 1011-1344 (ISSN-L)
- OpenAlex
- W2058264436
- Cited by
- 41
- References
- 53
- Citations by year
- 2025: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 1 · 2012: 1
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Photochemistry and Photobiology B Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kreftforeningen
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
- Keywords
- photodynamic therapy, 5-aminolevulinic acid, temperature dependence, photobleaching, protoporphyrin IX, cell survival, tumor heating, cell killing
- MeSH terms
- Aminolevulinic Acid, Cell Survival, Humans, Photochemotherapy, Spectrophotometry, Ultraviolet, Temperature, Cell Line, Tumor
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