The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Anti-tumor evaluation of a novel methoxyphenyl substituted chlorin photosensitizer for photodynamic therapy
Abstract
Photodynamic therapy (PDT) is a non-invasive and innovative therapeutic approach which has been increasingly applied in clinical cancer therapy. As the central element of PDT, the development of novel photosensitizers (PSs) with longer absorption wavelength, proper lipophilic/hydrophilic profiles, target tissue selectivity, and higher photo-/lowest dark-cytotoxicity is a challenging task. Previously, we designed and synthesized a series of novel long-wavelength chlorin e6 (Ce6)-based PSs via introducing aromatic groups to the vinyl of Ce6 skeleton. The new formed compounds with π-extension system exhibited improved photodynamic effects and spectral characteristics. Among these π-conjugated chlorin PSs, (E)-3 2-(4-methoxyphenyl)-chlorin e6, named A15, was expected to be a potent antitumor candidate as a PDT agent due to its good photobiological properties. Herein, in this work, we evaluated the effectiveness of A15 in cancer PDT. In vitro, a novel rare earth probe, ATTA-Eu 3+ was applied to detect the singlet oxygen (1 O 2) production of A15 in solution and human hepatoma HepG2 cells, respectively. Moreover, A15 exhibited strong phototoxicity and weak dark cytotoxity to HepG2 cells. In H22 tumor bearing mice, A15 showed excellent tumor accumulation ability via i.v. administration and induced tumor regression, followed by laser treatment. These results indicated that A15 is a potential novel π-extension chlorin-type PS for PDT applications.
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“A derivate of Ce6 ((E)-32-(4-methoxyphenyl)-chlorin e6), processed from Spirulina powder, exhibited phototoxicity against HepG2 cells, whose viability was only 10% at 1 μM [145].”
From Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp. (2023) · cites this paper as [145]
Citations
Cites
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Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor
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Singlet oxygen generation by photodynamic agents
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Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp.
Abreu, A. P., Martins, R., & Nunes, J. (2023) · Bioengineering · doi:10.3390/bioengineering10080955 · Cited by 119
Metadata
- Authors
- Dong, Y., Li, G., Wang, L., Cao, L., Li, Y., & Zhao, W.
- Affiliations
- Dalian University of Technology (CN)
- Corresponding author
- Li, Guangzhe
- Zhao, Weijie
- Venue
- Journal of Photochemistry and Photobiology B: Biology
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 211
- Pages
- 112015
- ISSN
- 1011-1344 (ISSN-L)
- OpenAlex
- W3083268711
- Cited by
- 20
- References
- 39
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 1 · 2021: 4
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Photochemistry and Photobiology B Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Key Projects of the National Science and Technology Pillar Program (2015BAD17B05)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Physical Sciences › Materials Science › Materials Chemistry › Porphyrin and Phthalocyanine Chemistry
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- chlorin e6, photosensitizers, photodynamic therapy, extended π-conjugation, singlet oxygen detection, HepG2 cells, H22 hepatocellular carcinoma, tumor accumulation, anticancer activity, dark cytotoxicity
- MeSH terms
- Animals, Antineoplastic Agents, Cell Survival, Humans, Hydrocarbons, Aromatic, Male, Mice, Inbred ICR, Photochemotherapy, Porphyrins, Structure-Activity Relationship, Photosensitizing Agents, Singlet Oxygen, Mice, Hep G2 Cells
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