Alarmins in chronic noncommunicable diseases: Atherosclerosis, diabetes and cancer
Abstract
There is a wide range of pathological conditions proved to be associated with inflammation. The inflammatory process offers protection against harmful stimuli such as induced cell injury and tissues damage by means of specialized mediators and cells. Alarmins, also known as endogenous danger signals or damage-associated molecular patterns (DAMPs) molecules, are critical players of immune response to tissue suffering. In many inflammatory and autoimmune conditions, alarmins are released into the extracellular milieu and bind to specific receptors to stimulate and promote activation of innate immune cells, cell differentiation, cell death or secretion of inflammatory mediators. This paper, based on biochemical and mass spectrometry proteomic data, highlights the role of heat shock proteins (HSPs), high-mobility group box 1 (HMGB1) protein and S100 proteins as main alarmins involved in the maintaining and amplifying inflammation in atherosclerosis, diabetes and cancer.Biological significance This paper, based on biochemical and mass spectrometry proteomic data, highlights the role of the heat shock proteins (HSPs), high-mobility group box 1 (HMGB1) protein and S100 proteins as main alarmins involved in maintaining and amplifying atherosclerosis, diabetes and cancer inflammation.
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Several human studies found that sleep reduces total leukocyte count compared with total sleep deprivation or sleep restriction lasting a few hours to several days.
“Several studies in humans have found a reducing effect of sleep on total leukocyte count when compared with total sleep deprivation or sleep restriction for either only a few hours or up to several days (67, 69, 152, 178, 287, 326, 338, 480).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [69]
Several studies found that sleep reduces neutrophil counts, although some studies did not find any changes.
“In contrast, several studies found that sleep reduces neutrophil counts (69, 112, 178, 287, 326, 338, 480, 580), although again some studies did not find any changes (67, 103, 122, 469).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [69]
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References 87 · Cited by 38
- Authors
- Boteanu, R. M., Suica, V. I., Uyy, E., Ivan, L., Dima, S. O., Popescu, I., Simionescu, M., & Antohe, F.
- Affiliations
- Romanian Academy (RO)
- Institutul Clinic Fundeni (RO)
- Corresponding author
- Antohe, Felicia
- Venue
- Journal of Proteomics
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 153
- Pages
- 21-29
- ISSN
- 1874-3919 (ISSN-L)
- OpenAlex
- W2552785834
- Cited by
- 38
- References
- 87
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 1 · 2022: 8 · 2021: 1 · 2020: 5 · 2019: 7 · 2018: 7 · 2017: 2
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Proteomics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Romanian Academy
- Ministry of Education and Research (90, 135, 153/2012)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- alarmins, damage-associated molecular patterns, inflammation, atherosclerosis, diabetes mellitus, cancer, heat shock proteins, HMGB1, S-100 protein, innate immune response, non-communicable diseases
- MeSH terms
- Alarmins, Noncommunicable Diseases, Animals, Chronic Disease, Diabetes Mellitus, Heat-Shock Proteins, Humans, Immunity, Innate, Inflammation, Neoplasms, S100 Proteins, HMGB1 Protein, Atherosclerosis
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