A review of neuroimaging studies in PTSD: heterogeneity of response to symptom provocation
Abstract
Different experiential, psychophysiological, and neurobiological responses to traumatic symptom provocation in posttraumatic stress disorder (PTSD) have been reported in the literature. Two subtypes of trauma response have been hypothesized, one characterized predominantly by hyperarousal and the other primarily dissociative, each one representing unique pathways to chronic stress-related psychopathology. Recent PTSD neuroimaging findings in our own laboratory support this notion and are consistent with the view that grouping all PTSD subjects, regardless of their different symptom patterns, in the same diagnostic category may interfere with our understanding of posttrauma psychopathology. This review will integrate findings of different experiential, psychophysiological, and neurobiological responses to traumatic symptom provocation with the clinical symptomatology and the neurobiology of PTSD.
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The waxy immobility that characterizes tonic immobility is mediated by activation of the VLPAG.
“The “waxy” immobility that characterizes tonic immobility is also mediated by activation of the VLPAG.28,47,97”
From Fear and the Defense Cascade (2015) · cites this paper as [97]
This pattern of brain activity is similar to that seen in patients with PTSD-DS during presentation of trauma-related scripts.
“this pattern of brain activity is similar to that seen in patients with the PTSD-DS during presentation of trauma-related scripts (Lanius et al., 2010(Lanius et al., , 2012(Lanius et al., , 2006)).”
From A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions (2016) · cites this paper as Lanius et al., 2006
Individuals with hyperarousal and flashback/reliving show less activation of the thalamus compared to those with depersonalization/derealization responses during responses to trauma scripts.
“More recent work has indicates that individuals with hyperarousal and flashback/reliving show less activation of the thalamus as compared to those with depersonalization/derealization responses during responses to trauma scripts (Lanius et al., 2006).”
From A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions (2016) · cites this paper as Lanius et al., 2006
Further research by Lanius and colleagues employing trauma memory recall supports the idea of two different PTSD profiles.
“Further research by Lanius and colleagues (Lanius et al., 2002; Lanius et al., 2005; Lanius et al., 2006) employing trauma memory recall supports the idea of two different PTSD profiles”
From Trauma-related dissociation and the autonomic nervous system: a systematic literature review of psychophysiological correlates of dissociative experiencing in PTSD patients (2022) · cites this paper as Lanius et al., 2006
The initial pilot studies describing alternating physiological reactions to individualized trauma scripts in chronic PTSD patients interpreted the data as supportive for two distinct subtypes 'each representing unique pathways to chronic stress-related psychopathology'.
“The initial pilot studies describing alternating physiological reactions to individualized trauma scripts in chronic PTSD patients (Lanius et al., 2001; Lanius et al., 2002) interpreted the data as supportive for two distinct subtypes ‘each representing unique pathways to chronic stress- related psychopathology’ (Lanius et al., 2006, p. 710).”
From Trauma-related dissociation and the autonomic nervous system: a systematic literature review of psychophysiological correlates of dissociative experiencing in PTSD patients (2022) · cites this paper as Lanius et al., 2006
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References 141 · Cited by 380
- Authors
- Lanius, R. A., Bluhm, R., Lanius, U., & Pain, C.
- Affiliations
- Western University (CA)
- Royal Columbian Hospital (CA)
- Corresponding author
- Lanius, R.A.
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 40
- Issue
- 8
- Pages
- 709-729
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2152332814
- Cited by
- 380
- References
- 141
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 10 · 2023: 14 · 2022: 10 · 2021: 14 · 2020: 23 · 2019: 16 · 2018: 19 · 2017: 24 · 2016: 20 · 2015: 28 · 2014: 27 · 2013: 25 · 2012: 32
- FWCI
- 9.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Keywords
- post-traumatic stress disorder, PTSD subtypes, hyperarousal, dissociation, psychophysiological responses
- MeSH terms
- Brain, Humans, Magnetic Resonance Imaging, Stress Disorders, Post-Traumatic
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