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Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: A potential link between epigenetics and schizophrenia
Abstract
Genetic and epigenetic factors can potentially alter susceptibility to psychiatric disorders such as schizophrenia. In order to explore the effect of epigenetics on the pathogenesis of schizophrenia, we examined the global methylation level of leukocyte DNA from 210 patients with schizophrenia (124 males and 86 females) and 237 healthy subjects (108 males and 129 females). Methylated deoxycytidine (mC) content in peripheral leukocyte DNA was measured by high performance liquid chromatography (HPLC). We confirmed in the healthy subjects our previous finding that there are sex-dependent differences in mC content (males>females; beta=0.319, p<0.001), in addition to the effect of age (beta=-0.141, p=0.022). We therefore used multiple regression to analyze the data from all subjects by sex, with age as a co-variant. In males, a tendency was observed toward lower mC content in patients than in controls (beta=-0.115, p=0.075), with a significant effect of age (beta=-0.212, p<0.001). This difference was more prominent in younger individuals. In females, no effect of age or disease status on mC content was observed. These results established that there is significant sex-dependent difference in the mC content of human peripheral leukocyte DNA, and raise the possibility that alterations in DNA methylation state are present in patients with schizophrenia.
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“In both human and animal models, it has been observed treatment with haloperidol induces sex-specific DNA methylation differences [71, 72].”
From Sex-specific DNA methylation differences in Alzheimer’s disease pathology (2021) · cites this paper as [72]
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Cites
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
Epigenetic differences arise during the lifetime of monozygotic twins
Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500398102 · Cited by 3,602
Cancer-epigenetics comes of age
Jones, P. A., & Laird, P. W. (1999) · Nature Genetics · doi:10.1038/5947 · Cited by 2,358
Cytosine methylation and the ecology of intragenomic parasites
Yoder, J. A., Walsh, C. P., & Bestor, T. H. (1997) · Trends in Genetics · doi:10.1016/s0168-9525(97)01181-5 · Cited by 1,562
Epigenetic inheritance at the agouti locus in the mouse
Morgan, H. D., Sutherland, H. G. E., Martin, D. I. K., & Whitelaw, E. (1999) · Nature Genetics · doi:10.1038/15490 · Cited by 1,476
Transcription of IAP endogenous retroviruses is constrained by cytosine methylation
Walsh, C. P., Chaillet, J. R., & Bestor, T. H. (1998) · Nature Genetics · doi:10.1038/2413 · Cited by 1,105
DNA methylation in health and disease
Robertson, K. D., & Wolffe, A. P. (2000) · Nature Reviews Genetics · doi:10.1038/35049533 · Cited by 1,077
A decrease of reelin expression as a putative vulnerability factor in schizophrenia
Impagnatiello, F., Guidotti, A. R., Pesold, C., Dwivedi, Y., Caruncho, H. J., Pisu, M. G., Uzunov, D. P., Smalheiser, N. R., Davis, J. M., Pandey, G. N., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15718 · Cited by 762
DNA Methylation Decreases in Aging But Not in Immortal Cells
Wilson, V. L., & Jones, P. A. (1983) · Science · doi:10.1126/science.6844925 · Cited by 654
Genomic 5-methyldeoxycytidine decreases with age.
Wilson, V. L., Smith, R. A., Ma, S., & Cutler, R. G. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61057-9 · Cited by 521
Metastable epialleles in mammals
Rakyan, V. K., Blewitt, M. E., Druker, R., Preis, J. I., & Whitelaw, E. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02709-9 · Cited by 499
Gibbons, R. J., McDowell, T. L., Raman, S., O’Rourke, D., Garrick, D., Ayyub, H., & Higgs, D. R. (2000) · Nature Genetics · doi:10.1038/74191 · Cited by 495
Fuke, C., Shimabukuro, M., Petronis, A., Sugimoto, J., Oda, T., Miura, K., Miyazaki, T., Ogura, C., Okazaki, Y., & Jinno, Y. (2004) · Annals of Human Genetics · doi:10.1046/j.1529-8817.2004.00081.x · Cited by 404
Self-citationTremolizzo, L., Carboni, G., Ruzicka, W. B., Mitchell, C. P., Sugaya, I., Tueting, P. A., Sharma, R. P., Grayson, D. R., Costa, E., & Guidotti, A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.262658999 · Cited by 388
Szymanski, S., Lieberman, J. A., Alvir, J. M., Mayerhoff, D. I., Loebel, A., Geisler, S., Chakos, M., Koreen, A., Jody, D. N., & Kane, J. M. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.5.698 · Cited by 319
Epigenetic inheritance in the mouse
Römer, I., Reik, W., Dean, W., & Klose, J. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00124-2 · Cited by 248
The origin of schizophrenia: genetic thesis, epigenetic antithesis, and resolving synthesis
Petronis, A. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.005 · Cited by 225
Rett Syndrome and MeCP2: Linking Epigenetics and Neuronal Function
Shahbazian, M. D., & Zoghbi, H. Y. (2002) · The American Journal of Human Genetics · doi:10.1086/345360 · Cited by 204
Genetics of Schizophrenia and the New Millennium: Progress and Pitfalls
Baron, M. (2001) · The American Journal of Human Genetics · doi:10.1086/318212 · Cited by 184
Reynolds, E. H., Carney, M. W. P., & Toone, B. (1984) · The Lancet · doi:10.1016/s0140-6736(84)90482-3 · Cited by 158
Rao, M. L., & Kölsch, H. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00126-9 · Cited by 126
Epigenomics: Mapping the Methylome
Wilson, I. M., Davies, J. J., Weber, M., Brown, C. J., Alvarez, C. E., MacAulay, C. E., Schübeler, D., & Lam, W. L. (2005) · Cell Cycle · doi:10.4161/cc.5.2.2367 · Cited by 122
Dynamics of DNA methylation pattern
Hsieh, C. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00064-2 · Cited by 99
Huber, T. J., Tettenborn, C., Leifke, E., & Emrich, H. M. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.05.010 · Cited by 91
Quantitative changes in T cell DNA methylation occur during differentiation and ageing
Golbus, J., Palella, T. D., & Richardson, B. C. (1990) · European Journal of Immunology · doi:10.1002/eji.1830200836 · Cited by 91
Psychotic disorders and gonadal function: evidence supporting the oestrogen hypothesis
Huber, T. J., Borsutzky, M., Schneider, U., & Emrich, H. M. (2004) · Acta Psychiatrica Scandinavica · doi:10.1046/j.1600-0447.2003.00251.x · Cited by 86
Psychiatric genetics: back to the future
Owen, M. J., Cardno, A. G., & O’Donovan, M. C. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000702 · Cited by 82
MATERNAL NUTRITION AND LOW BIRTH-WEIGHT
Susser, M. W., & STEIN, Z. A. (1976) · The Lancet · doi:10.1016/s0140-6736(76)91302-7 · Cited by 79
Drinkwater, R. D., Blake, T. J. A., Morley, A. A., & Turner, D. R. (1989) · Mutation Research/DNAging · doi:10.1016/0921-8734(89)90038-6 · Cited by 78
Reactivation of heritably silenced gene expression in mice
Sutherland, H. G. E., Kearns, M., Morgan, H. D., Headley, A. P., Morris, C., Martin, D. I. K., & Whitelaw, E. (2000) · Mammalian Genome · doi:10.1007/s003350010066 · Cited by 73
Gogos, A., & van den Buuse, M. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.061432 · Cited by 71
Genomic Discordance Between Monozygotic Twins Discordant for Schizophrenia
Tsujita, T., Niikawa, N., Yamashita, H., Imamura, A., Hamada, A., Nakane, Y., & Okazaki, Y. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.3.422 · Cited by 63
Self-citationHomocysteinemia and schizophrenia as a case of methylation deficiency
Regland, B., Johansson, B. V., & Gottfries, C. G. (1994) · Journal of Neural Transmission · doi:10.1007/bf01277017 · Cited by 54
Molecular genetic studies of schizophrenia: challenges and insights
Kato, C., Petronis, A., Okazaki, Y., Tochigi, M., Umekage, T., & Sasaki, T. (2002) · Neuroscience Research · doi:10.1016/s0168-0102(02)00064-0 · Cited by 39
Self-citationSmythies, J., Alarcón, R. D., Morere, D. A., Monti, J. A., Steele, M., Tolbert, L. C., & Walter-Ryan, W. G. (1986) · Biological Psychiatry · doi:10.1016/0006-3223(86)90330-6 · Cited by 35
Kelsoe, J. R., Tolbert, L. C., Crews, E. L., & Smythies, J. (1982) · Journal of Neuroscience Research · doi:10.1002/jnr.490080113 · Cited by 30
Human endogenous retroviruses with transcriptional potential in the brain
Nakamura, A., Okazaki, Y., Sugimoto, J., Oda, T., & Jinno, Y. (2003) · Journal of Human Genetics · doi:10.1007/s10038-003-0081-8 · Cited by 29
Self-citationShen, H., Nakamura, A. M., Sugimoto, J., Sakumoto, N., Oda, T., Jinno, Y., & Okazaki, Y. (2006) · Journal of Human Genetics · doi:10.1007/s10038-006-0382-9 · Cited by 15
Self-citationMedication Effects on One-Carbon Metabolism in
Morere, D. A., Alarcón, R. D., Monti, J. A., Walter-Ryan, W. G., Bancroft, A. A., Smythies, J., & Tolbert, L. C. (1986) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-198606000-00006 · Cited by 12
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Hou, L., Zhang, X., Wang, D., & Baccarelli, A. (2011) · International Journal of Epidemiology · doi:10.1093/ije/dyr154 · Cited by 502
DNA methylation in white blood cells
Terry, M. B., Delgado‐Cruzata, L., Vin‐Raviv, N., Wu, H. C., & Santella, R. M. (2011) · Epigenetics · doi:10.4161/epi.6.7.16500 · Cited by 326
El‐Maarri, O., Becker, T., Junen, J., Manzoor, S. S., Diaz-Lacava, A. N., Schwaab, R., Wienker, T. F., & Oldenburg, J. (2007) · Human Genetics · doi:10.1007/s00439-007-0430-3 · Cited by 276
Unternaehrer, E., Luers, P., Mill, J., Dempster, E., Meyer, A. H., Staehli, S., Lieb, R., Hellhammer, D. H., & Meinlschmidt, G. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.77 · Cited by 250
DNA hypomethylation in the origin and pathogenesis of human diseases
Pogribny, I. P., & Beland, F. A. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0015-5 · Cited by 225
Metadata
- Authors
- Shimabukuro, M., Sasaki, T., Imamura, A., Tsujita, T., Fuke, C., Umekage, T., Tochigi, M., Hiramatsu, K., Miyazaki, T., Oda, T., Sugimoto, J., Jinno, Y., & Okazaki, Y.
- Affiliations
- University of the Ryukyus (JP)
- The University of Tokyo (JP)
- Nagasaki University (JP)
- Mie University (JP)
- Corresponding author
- Jinno, Yoshihiro
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2007-12
- Volume
- 41
- Issue
- 12
- Pages
- 1042-1046
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2148944032
- Cited by
- 108
- References
- 40
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 6 · 2016: 10 · 2015: 7 · 2014: 8 · 2013: 5 · 2012: 14
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- schizophrenia, DNA methylation, global hypomethylation, peripheral blood leukocytes, epigenetics, sex differences, age effects
- MeSH terms
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Child, Chromatography, High Pressure Liquid, Female, Humans, Leukocytes, Male, Middle Aged, Schizophrenia, Sex Factors, DNA Methylation, Epigenesis, Genetic
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