The effects of child abuse and neglect on cognitive functioning in adulthood
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Aims Recent research has revealed that early life trauma (ELS), including abuse (sexual and/or physical) and neglect, produce lasting changes in the CNS. We posited that cognitive deficits, often observed in psychiatric patients, result, in part, due to the neurobiological consequences of ELS. Additionally, we hypothesized that the nature and magnitude of cognitive deficits would differ according to the subtype of ELS experienced. Method The Cambridge Neuropsychological Test Automated Battery (CANTAB) was used to assess neurocognitive functioning in 93 subjects (60 with ELS and 33 without). In the patients with a history of ELS, 35% and 16.7%, respectively, met criteria for current major depression and PTSD. Results Significant associations between ELS status and CANTAB measures of memory and executive and emotional functioning were found. Conclusions These data suggest that exposure to ELS results in a cascade of neurobiological changes associated with cognitive deficits in adulthood that vary according to the type of trauma experienced.
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Cognitive deficits are more frequent among individuals with experiences of ELA.
“Cognitive deficits are also more frequent among individuals with experiences of ELA 84 .”
From Suicide and suicide risk (2019) · cites this paper as [84]
Prior research in clinical and nonclinical groups has linked neurodevelopmental changes caused by childhood trauma to executive function deficits.
“Previous research in clinical and nonclinical populations has established a link between the neurodevelopmental changes caused by CT and deficits in executive function”
From Impact of Childhood Trauma on Executive Function in Adolescence—Mediating Functional Brain Networks and Prediction of High-Risk Drinking (2020) · cites this paper as [11]
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References 47 · Cited by 367
Research works printed but not linked: 4
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- Authors
- Gould, F., Clarke, J., Heim, C., Harvey, P. D., Majer, M., & Nemeroff, C. B.
- Affiliations
- University of Miami (US)
- Emory University (US)
- Corresponding author
- Nemeroff, Charles B.
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 46
- Issue
- 4
- Pages
- 500-506
- ISSN
- 0022-3956 (ISSN-L)
- PMC
- PMC3307950
- OpenAlex
- W2019206689
- Cited by
- 367
- References
- 47
- Citations by year
- 2026: 14 · 2025: 20 · 2024: 25 · 2023: 26 · 2022: 31 · 2021: 21 · 2020: 42 · 2019: 48 · 2018: 28 · 2017: 30 · 2016: 24 · 2015: 23 · 2014: 20 · 2013: 11 · 2012: 3
- FWCI
- 20.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (P50MH058922, MH58922)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- child abuse, child neglect, early trauma, cognitive impairment, neurocognitive function, memory, executive function, emotional functioning, major depressive disorder, post-traumatic stress disorder, CANTAB
- MeSH terms
- Adolescent, Adult, Child Abuse, Cognition Disorders, Depressive Disorder, Major, Major Depressive Disorder, Emotions, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Surveys and Questionnaires, Statistics as Topic, Young Adult, Self Report
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