Working memory deficits affect risky decision-making in methamphetamine users with attention-deficit/hyperactivity disorder
Open accessAbstract
Methamphetamine (MA) use and Attention-Deficit/Hyperactivity Disorder (ADHD) commonly co-occur and are independently associated with dysregulation of frontostriatal loops and risky decision-making; however, whether their comorbidity exacerbates risky decision-making is not known. This study evaluated 23 participants with histories of MA dependence and ADHD (MA+ADHD+), 25 subjects with MA dependence alone (MA+ADHD-), and 22 healthy adults (MA-ADHD-), who completed the Iowa Gambling Task (IGT) as part of a larger neuropsychiatric research evaluation. Results showed a significant interaction between ADHD, MA, and working memory, such that individuals with working memory deficits in the MA+ADHD+ cohort demonstrated the strongest propensity to select cards from "disadvantageous" versus "advantageous" decks on the IGT. This effect was not better explained by other psychiatric, substance use, neuromedical, or cognitive factors. Findings suggest that working memory deficits may moderate the expression of risky decision-making in MA users with ADHD.
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Two other studies reported no greater levels of risky performance in adults with ADHD on the standard IGT compared to NCs, and one other study only revealed aberrant performance on the standard IGT in a subgroup of adults with ADHD with both hard drug dependence and working memory problems.
“Much like Agay et al. [59], two other studies have also reported no greater levels of risky performance in adults with ADHD on the standard IGT when compared to NCs [61], [64], and one other study only revealed aberrant performance on the standard IGT in a subgroup of adults with ADHD with both hard drug dependence and working memory problems [60].”
From Risky behavior in gambling tasks in individuals with ADHD–a systematic literature review (2013) · cites this paper as [60]
Null findings were reported in 4/15 (27%) of studies with null findings in which participants were MPH-naïve.
“MPH-naïve patients: 4/15 = 27% of studies with null findings [54], [60], [66], [68]”
From Risky behavior in gambling tasks in individuals with ADHD–a systematic literature review (2013) · cites this paper as [60]
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References 62 · Cited by 56
- Authors
- Duarte, N. A., Woods, S. P., Rooney, A., Atkinson, J. H., & Grant, I.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Woods, Steven Paul
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 46
- Issue
- 4
- Pages
- 492-499
- ISSN
- 0022-3956 (ISSN-L)
- PMC
- PMC3307875
- OpenAlex
- W2133280615
- Cited by
- 56
- References
- 62
- Citations by year
- 2025: 7 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 4 · 2017: 6 · 2016: 8 · 2015: 3 · 2014: 2 · 2013: 6 · 2012: 2
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (P30MH062512)
- National Institute on Drug Abuse (P50DA026306, P01DA012065)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- methamphetamine dependence, attention deficit hyperactivity disorder, working memory deficits, risky decision making, Iowa Gambling Task, frontostriatal circuits, substance use disorders
- MeSH terms
- Adult, Analysis of Variance, Attention Deficit Disorder with Hyperactivity, Decision Making, Female, Follow-Up Studies, Humans, Male, Memory Disorders, Memory, Short-Term, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Risk-Taking, Amphetamine-Related Disorders
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