The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration
Open accessAbstract
Current evidences support inflammation, oxidative and nitrogen stress, as well as brain-derived neurotrophic factor (BDNF) signaling mechanisms as important in depression pathophysiology. Tetracycline antibiotics have anti-inflammatory and antioxidant properties. Preliminary evidence indicates that minocycline has antidepressant properties. Doxycycline (DOXY) has favorable pharmacokinetic and safety profiles when compared to other tetracycline congeners. The antidepressant activity of DOXY has not been adequately investigated. This study evaluated the effects of DOXY (25 and 50 mg/kg, i.p.) on LPS-induced (0.5 mg/kg, i.p.) depressive-like behavior. Doxycycline was administered 30 min before LPS (pre-LPS) or 1.5 and 23.5 h following LPS (post-LPS) administration in mice. LPS-treated animals presented an increase in immobility time in the forced swimming test (FST) when compared to controls 24 h after endotoxin administration. Similarly to imipramine (IMI-10 mg/kg, i.p.), DOXY at both doses prevented and reversed LPS-induced alterations in the FST. IL-1β content was increased 24 h after LPS administration in striatum, hippocampus and prefrontal cortex. IMI and DOXY prevented and reversed LPS-induced increase in IL-1β. IMI and DOXY also prevented and reversed LPS-induced alterations in nitrite content and oxidative stress parameters (lipid peroxidation and reduced glutathione levels). Both DOXY and IMI prevented LPS-induced decrease in hippocampal BDNF levels. Taken together, our results demonstrate that DOXY is comparable to IMI in effectively ameliorate LPS-induced depressive-like behavior, providing a rationale for testing DOXY's antidepressant efficacy in humans.
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“Conversely, certain antibiotics, such as β-lactams and tetracyclines have potential antidepressant properties in rodents and humans [161,162].”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [161]
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Cites
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Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
O’Mahony, S. M., Clarke, G., Borre, Y. E., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.027 · Cited by 2,012
The central nervous system and the gut microbiome
Sharon, G., Sampson, T. R., Geschwind, D. H., & Mazmanian, S. K. (2016) · Cell · doi:10.1016/j.cell.2016.10.027 · Cited by 1,513
Inflamed moods: A review of the interactions between inflammation and mood disorders
Rosenblat, J. D., Cha, D. S., Mansur, R. B., & McIntyre, R. S. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.01.013 · Cited by 609
Self-citationAnxiety, depression, and the microbiome: A role for gut peptides
Lach, G., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0585-0 · Cited by 573
The gut microbiome and diet in psychiatry: focus on depression
Dash, S., Clarke, G., Berk, M., & Jacka, F. N. (2015) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000117 · Cited by 369
Metadata
- Authors
- Ferreira Mello, B. S., Monte, A. S., McIntyre, R. S., Soczynska, J. K., Custódio, C. S., Cordeiro, R. C., Chaves, J. H., Mendes Vasconcelos, S. M., Nobre Júnior, H. V., Florenço de Sousa, F. C., Hyphantis, T. N., Carvalho, A. F., & Macêdo, D. S.
- Affiliations
- Universidade Federal do Ceará (BR)
- University Health Network (CA)
- University of Toronto (CA)
- University of Ioannina (GR)
- Corresponding author
- Macêdo, Danielle Silveira
- ORCID
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 47
- Issue
- 10
- Pages
- 1521-1529
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2081306572
- Cited by
- 195
- References
- 99
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 10 · 2023: 12 · 2022: 16 · 2021: 22 · 2020: 20 · 2019: 20 · 2018: 19 · 2017: 18 · 2016: 13 · 2015: 15 · 2014: 15
- FWCI
- 4.85
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- doxycycline, antidepressant effects, depression-like behavior, lipopolysaccharide, neuroinflammation, brain-derived neurotrophic factor, IL-1β, oxidative stress, lipid peroxidation, glutathione, imipramine, tetracycline antibiotics, forced swim test, hippocampus, prefrontal cortex, striatum
- MeSH terms
- Animals, Antidepressive Agents, Brain, Depression, Disease Models, Animal, Dose-Response Relationship, Drug, Doxycycline, Exploratory Behavior, Gene Expression Regulation, Glutathione, Lipopolysaccharides, Male, Nitrites, Swimming, Tumor Necrosis Factor-alpha, Thiobarbituric Acid Reactive Substances, Statistics, Nonparametric, Brain-Derived Neurotrophic Factor, Mice, Interleukin-1beta
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