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Cited by 156Cardiac Health and Mental HealthHeart Failure Treatment and ManagementHeart Rate Variability and Autonomic Control

The DOI matches its Crossref record; 46 of the 47 references it cites were found in a registry or an index.

Depression increases the risk of mortality in patients with heart failure: a meta-analysis.

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Gathright, Emily C., Goldstein, Carly M., Josephson, Richard A., Hughes, Joel W.·2017·Journal of Psychosomatic Research
DOI 10.1016/j.jpsychores.2017.01.010PMC PMC5370194
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Abstract

Background Depression is a risk factor for mortality in cardiovascular diseases. Prior studies confirm that depression predicts adverse outcomes in patients with heart failure (HF). However, data were inconclusive regarding the effect of depression on mortality. This meta-analysis examines the relationship between depression and mortality in HF.Methods Prospective studies of depression and mortality in HF published between 1999 and April 2016 were located using PubMed, PsychINFO, and MEDLINE. Comprehensive Meta-Analysis software was used to compute an aggregated effect size estimates of hazard ratios and to conduct subgroup analyses.Results Eighteen studies met inclusion criteria. For 8 aggregated univariate and 14 multivariate estimates, depressive symptoms were related to all-cause mortality. A pooled HR of 3 multivariate analyses indicated that depressive symptoms were not linked to cardiovascular mortality. In subgroup analyses, depression predicted all-cause mortality in samples with a mean age >65. The impact of depression on all-cause mortality also differed by follow-up duration, with samples with shorter follow-up durations demonstrating a larger effect.Conclusions In HF, depression is related to increased all-cause mortality risk, with stronger effects in samples with shorter follow-up and in older adults. In older adults, depression may serve as a marker of more severe HF. However, this possibility is difficult to examine given inconsistent adjustment for HF severity. Additional studies may assist in determining the relationship between depression and cardiovascular mortality, as the low number of studies examining cardiovascular mortality may have precluded detection of an effect.

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Metadata

Authors
Gathright, E. C., Goldstein, C. M., Josephson, R. A., & Hughes, J. W.
Affiliations
  • Kent State University (US)
  • Brown University (US)
  • University Hospitals of Cleveland (US)
Corresponding author
Gathright, Emily C.
ORCID
Venue
Journal of Psychosomatic Research
Publisher
Elsevier BV
Published
2017-03
Volume
94
Pages
82-89
ISSN
0022-3999 (ISSN-L)
DOI
10.1016/j.jpsychores.2017.01.010
PMC
PMC5370194
OpenAlex
W2579918759
Cited by
156
References
47
Citations by year
2026: 12 · 2025: 14 · 2024: 19 · 2023: 17 · 2022: 16 · 2021: 21 · 2020: 22 · 2019: 17 · 2018: 11 · 2017: 7
FWCI
2.21
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Psychosomatic Research (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Heart, Lung, and Blood Institute (T32HL076134)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
depression, heart failure, mortality, all-cause mortality, cardiovascular mortality, depressive symptoms, older adults, follow-up duration
MeSH terms
Depression, Heart Failure, Humans, Risk Factors

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