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Cited by 22Sperm and Testicular FunctionHormonal and reproductive studiesHypothalamic control of reproductive hormones

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Association of the (TAAAA)n repeat and Asp327Asn polymorphisms in the sex hormone-binding globulin (SHBG) gene with idiopathic male infertility and relation to serum SHBG concentrations

Safarinejad, Mohammad Reza, Shafiei, Nayyer, Safarinejad, Shiva·2011·The Journal of Steroid Biochemistry and Molecular Biology
DOI 10.1016/j.jsbmb.2010.10.005
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Abstract

Sex hormone binding globulin (SHBG) is involved in delivering sex hormones to target tissues. We investigated the association between the (TAAAA)n repeat polymorphism, and Asp327Asn polymorphism in the SHBG gene with semen quality and idiopathic male infertility. We studied 168 men with idiopathic infertility [oligoasthenoteratozoospermia (OAT)] and equal number of age-matched normal controls. The serum levels of SHBG, reproductive and thyroid hormones, and Inhibin B were measured. Semen parameters were also assessed. The genotype assays for the SHBG polymorphism were done using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Baseline SHBG levels tended to be lower in infertile men (21.1±7.2nmol/l) compared to normal fertile men (24.7±7.9nmol/l). SHBG levels tended to be higher among the subjects with the Asn/Asn (25.84±3.6nmol/l) and S/S (24.50±5.4nmol/l) genotypes compared to subjects with the Asp/Asn (24.38±3.2nmol/l) and L/L (18.44±4.2nmol/l) genotypes of the SHBG gene. The genotype frequencies of Asp/Asp were 80.9% in cases and 71.4% in controls (P=0.001). The variant Asp/Asn genotype was associated with a more than 50% reduced risk of infertility (OR: 0.46, 95% CI: 0.25-0.80, P=0.001). Genotype analysis demonstrated six SHBG (TAAAA)n alleles with 6-11 repeats. Long SHBG (TAAAA)n alleles (>8 repeats) were at greater frequency in infertile men than fertile subjects (P=0.001), whereas short SHBG (TAAAA)n alleles (≤8 repeats) ten…

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Metadata

Authors
Safarinejad, M. R., Shafiei, N., & Safarinejad, S.
Corresponding author
Safarinejad, Mohammad Reza
ORCID
Safarinejad, Mohammad Reza
Venue
The Journal of Steroid Biochemistry and Molecular Biology
Publisher
Elsevier BV
Published
2011-01
Volume
123
Issue
1-2
Pages
37-45
ISSN
0960-0760 (ISSN-L)
DOI
10.1016/j.jsbmb.2010.10.005
OpenAlex
W2131078160
Cited by
22
References
1
Citations by year
2025: 1 · 2024: 2 · 2023: 5 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 2 · 2015: 1 · 2014: 1 · 2012: 2
FWCI
1.14
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
sex hormone-binding globulin, SHBG gene, idiopathic male infertility, oligoasthenoteratozoospermia, semen quality, genetic susceptibility, inhibin B, thyroid hormones, sex hormones, genotype-phenotype correlation, infertility risk factors
MeSH terms
Adult, Aspartic Acid, DNA, Genotype, Humans, Infertility, Male, Male, Middle Aged, Polymorphism, Genetic, Repetitive Sequences, Nucleic Acid, Sex Hormone-Binding Globulin, Multivariate Analysis, Semen Analysis

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