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Cited by 43Cholesterol and Lipid MetabolismSteroid Chemistry and BiochemistrySphingolipid Metabolism and Signaling

Nuclear receptors, cholesterol homeostasis and the immune system

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Shahoei, Sayyed Hamed, Nelson, Erik R.·2019·The Journal of Steroid Biochemistry and Molecular Biology
DOI 10.1016/j.jsbmb.2019.04.013PMC PMC6589364
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Abstract

Cholesterol is essential for maintaining membrane fluidity in eukaryotes. Additionally, the synthetic cascade of cholesterol results in precursor molecules important for cellular function such as lipid raft formation and protein prenylation. As such, cholesterol homeostasis is tightly regulated. Interestingly, it is now known that some cholesterol precursors and many metabolites serve as active signaling molecules, binding to different classes of receptors including the nuclear receptors. Furthermore, many cholesterol metabolites or their nuclear receptors have been implicated in the regulation of the immune system in normal physiology and disease. Therefore, in this focused review, cholesterol homeostasis and nuclear receptors involved in this regulation will be discussed, with particular emphasis on how these cascades influence the immune system.

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Cited by

Sorted by citations

Authors
Shahoei, S. H., & Nelson, E. R.
Affiliations
University of Illinois Urbana-Champaign (US)
Corresponding author
Nelson, Erik R.
ORCID
Venue
The Journal of Steroid Biochemistry and Molecular Biology
Publisher
Elsevier BV
Published
2019-07
Volume
191
Pages
105364
ISSN
0960-0760 (ISSN-L)
DOI
10.1016/j.jsbmb.2019.04.013
PMC
PMC6589364
OpenAlex
W2936573240
Cited by
43
References
11
Citations by year
2026: 4 · 2025: 4 · 2024: 4 · 2023: 11 · 2022: 7 · 2021: 5 · 2020: 7 · 2019: 1
FWCI
1.03
Type
journal article
Language
en
Open access
Licence
Locations
  • The Journal of Steroid Biochemistry and Molecular Biology (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Department of Defense
  • National Institutes of Health
Topics
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
Keywords
nuclear receptors, cholesterol homeostasis, bile acid homeostasis, cholesterol metabolites, immune regulation, membrane fluidity, lipid rafts, protein prenylation, signaling molecules
MeSH terms
Animals, Cholesterol, Homeostasis, Humans, Immune System, Immunity, Receptors, Cytoplasmic and Nuclear

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