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Evaluation of cytotoxicity, cell cycle arrest and apoptosis induced by Anethum graveolens L. essential oil in human hepatocellular carcinoma cell line

Al-Sheddi, Ebtesam S., Al-Zaid, Nouf A., Al-Oqail, Mai M., Al-Massarani, Shaza M., El-Gamal, Ali A., Farshori, Nida N.·2019·Saudi Pharmaceutical Journal
DOI 10.1016/j.jsps.2019.09.001PMC PMC6978617
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Fig. 1 GC–MS chromatogram of Anethum graveolens essential oil (AG-EO).
Fig. 1 GC–MS chromatogram of Anethum graveolens essential oil (AG-EO).CC BY-NC-ND · PubMed Central
Fig. 2 Cytotoxicity assessment by MTT assay in HepG2 cells following the exposure of various concentrations of Anethum graveolens essential oil (AG-EO) for 24 h.
Fig. 2 Cytotoxicity assessment by MTT assay in HepG2 cells following the exposure of various concentrations of Anethum graveolens essential oil (AG-EO) for 24 h.CC BY-NC-ND · PubMed Central
Fig. 3 Cell cycle analysis in HepG2 cells exposed to Anethum graveolens essential oil (AG-EO) for 24 h. Representative flow cytometric image exhibiting changes in the progression of cell cycle. [A]: Control; [B]: 20 μg/ml; [C]: 60 μg/ml; [D]: 200 μg/ml.
Fig. 3 Cell cycle analysis in HepG2 cells exposed to Anethum graveolens essential oil (AG-EO) for 24 h. Representative flow cytometric image exhibiting changes in the progression of cell cycle. [A]: Control; [B]: 20 μg/ml; [C]: 60 μg/ml; [D]: 200 μg/ml.CC BY-NC-ND · PubMed Central
Fig. 4 Flow cytometry analysis of apoptosis in HepG2 cells exposed to various concentrations of treated with various concentrations of Anethum graveolens essential oil (AG-EO). The scatter plots show total, early apoptosis, late apoptotic and necrotic cells following 24 h exposure. [A]: Control; [B]: 20 μg/ml; [C]: 60 μg/ml; [D]: 200 μg/ml.
Fig. 4 Flow cytometry analysis of apoptosis in HepG2 cells exposed to various concentrations of treated with various concentrations of Anethum graveolens essential oil (AG-EO). The scatter plots show total, early apoptosis, late apoptotic and necrotic cells following 24 h exposure. [A]: Control; [B]: 20 μg/ml; [C]: 60 μg/ml; [D]: 200 μg/ml.CC BY-NC-ND · PubMed Central

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Research works printed but not linked: 48

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Cited by

Metadata

Authors
Al-Sheddi, E. S., Al-Zaid, N. A., Al-Oqail, M. M., Al-Massarani, S. M., El-Gamal, A. A., & Farshori, N. N.
Venue
Saudi Pharmaceutical Journal
Publisher
Springer Science and Business Media LLC
Published
2019-11
Volume
27
Issue
7
Pages
1053-1060
ISSN
1319-0164
DOI
10.1016/j.jsps.2019.09.001
PMC
PMC6978617
Cited by
41
References
0
Language
en
Licence
Funders
Deanship of Scientific Research, King Saud University

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