Extracellular signal–regulated kinase 1/2 is involved in a tamoxifen neuroprotective effect in a lateral fluid percussion injury rat model

Tsai, Yin-Tzu; Wang, Che-Chuan; Leung, Pak-On; Lin, Kao-Chang; Chio, Chung-Ching; Hu, Chiao-Ya; Kuo, Jinn-Rung

doi:10.1016/j.jss.2014.02.009

Extracellular signal–regulated kinase 1/2 is involved in a tamoxifen neuroprotective effect in a lateral fluid percussion injury rat model

Background The aim of the present study was to determine whether tamoxifen (TMX) causes attenuation of traumatic brain injury (TBI) induced by fluid percussion injury. Materials and methods Immediately after the onset of fluid percussion TBI, anesthetized male Sprague-Dawley rats were divided int…