MP85-20 RELATIONSHIP BETWEEN ENDOGENOUS TESTOSTERONE AND LIPID PARAMETERS: INSIGHT FROM REDUCE STUDY GROUP DATABASE

Abstract

You have accessJournal of UrologySexual Function/Dysfunction: Medical, Hormonal & Non-surgical Therapy II1 Apr 2018MP85-20 RELATIONSHIP BETWEEN ENDOGENOUS TESTOSTERONE AND LIPID PARAMETERS: INSIGHT FROM REDUCE STUDY GROUP DATABASE Kelly T. Harris, Amin S. Herati, Gerald L. Andriole, Ramiro Castro-Santamaria, Stephen J. Freedland, and Daniel M. Moreira Kelly T. HarrisKelly T. Harris More articles by this author , Amin S. HeratiAmin S. Herati More articles by this author , Gerald L. AndrioleGerald L. Andriole More articles by this author , Ramiro Castro-SantamariaRamiro Castro-Santamaria More articles by this author , Stephen J. FreedlandStephen J. Freedland More articles by this author , and Daniel M. MoreiraDaniel M. Moreira More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.2880AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Puberty and exogenous androgens have been known to induce an increase in total cholesterol, low-density lipoprotein cholesterol (LDL-C) and triglycerides, but decrease high-density lipoprotein cholesterol (HDL-C). This has led to the hypothesis that testosterone has a negative effect on lipid parameters and cardiovascular health. This study aimed to evaluate the relationship between serum lipids and endogenous testosterone levels. METHODS We analyzed data of 8043 men in the REduction by DUtasteride of prostate Cancer Events (REDUCE) study with baseline testosterone and lipid data (total cholesterol, HDL-C, LDL-C, and triglycerides). The relationship between baseline testosterone and lipid levels were analyzed using uni- and multivariate linear regression. RESULTS In both uni- and multivariable analyses, higher total cholesterol and triglycerides were associated with lower total testosterone while higher HDL-C and LDL-C are associated with higher testosterone (all P<0.001). On multivariate analysis, for each increase in 1 mmol/L (39 ng/dL) of total cholesterol there is a decrease of 0.18 nmol/L in total testosterone (5 ng/dL). For each increase of 1 mmol/L (39 ng/dL) in HDL there is an increase of 1.10 nmol/L in total testosterone (32 ng/dL, all P<0.05). CONCLUSIONS Data from REDUCE indicate that higher total cholesterol and triglycerides are associated with lower total testosterone and higher HDL-C and LDL-C are associated with higher total testosterone. The clinical significance of this is unknown, but does differ from prior studies. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e1176 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Kelly T. Harris More articles by this author Amin S. Herati More articles by this author Gerald L. Andriole More articles by this author Ramiro Castro-Santamaria More articles by this author Stephen J. Freedland More articles by this author Daniel M. Moreira More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...