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Cited by 392Osteoarthritis Treatment and MechanismsMesenchymal stem cell researchPeriodontal Regeneration and Treatments

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Infrapatellar fat pad-derived mesenchymal stem cell therapy for knee osteoarthritis

Koh, Yong-Gon, Choi, Yun-Jin·2012·The Knee
DOI 10.1016/j.knee.2012.04.001
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Abstract

Purpose The aim of the study was to determine if isolated mesenchymal stem cells (MSCs) derived from the infrapatellar fat pad could effectively improve clinical results when percutaneously injected into arthritic knees. Level of evidence Therapeutic case-control study; Level III. Methods Twenty five stem cell injections combined with arthroscopic debridement were administered to patients with knee OA. A mean of 1.89 × 10(6) stem cells were prepared with approximately 3.0 mL of platelet-rich plasma (PRP) and injected in the selected knees of patients in the study group. Results The mean Lysholm, Tegner activity scale, and VAS scores of patients in the study group improved significantly by the last follow-up visit. No major adverse events related to the injections were observed during the treatment and follow-up periods. The results were compared between the study and control groups, in which the patients had undergone arthroscopic debridement and PRP injection without stem cells. Although the preoperative mean Lysholm, Tegner activity scale, and VAS scores of the study group were significantly poorer than those of the control group, the clinical results at the last follow-up visit were similar and not significantly different between the two groups. Conclusions The short-term results of our study are encouraging and demonstrate that infrapatellar fat pad-derived MSC therapy with intraarticular injections is safe, and provides assistance in reducing pain and improving function in patients with knee OA.

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Metadata

Authors
Koh, Y.-G., & Choi, Y.-J.
Affiliations
Yonsei Sarang Hospital (KR)
ORCID
Koh, Yong-Gon
Venue
The Knee
Publisher
Elsevier BV
Published
2012-12
Volume
19
Issue
6
Pages
902-907
ISSN
0968-0160 (ISSN-L)
DOI
10.1016/j.knee.2012.04.001
OpenAlex
W2139826506
Cited by
392
References
0
Citations by year
2026: 9 · 2025: 19 · 2024: 17 · 2023: 24 · 2022: 27 · 2021: 34 · 2020: 36 · 2019: 36 · 2018: 49 · 2017: 40 · 2016: 33 · 2015: 18 · 2014: 29 · 2013: 20 · 2012: 1
FWCI
15.92
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Knee (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
  • Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
Keywords
knee osteoarthritis, mesenchymal stem cells, infrapatellar fat pad, stem cell therapy, intra-articular injection, platelet-rich plasma, arthroscopic debridement, analgesia, functional outcome
MeSH terms
Adipose Tissue, Adult, Aged, Arthroscopy, Debridement, Female, Humans, Injections, Intra-Articular, Male, Middle Aged, Retrospective Studies, Range of Motion, Articular, Treatment Outcome, Recovery of Function, Osteoarthritis, Knee, Mesenchymal Stem Cell Transplantation, Platelet-Rich Plasma

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