Endogenous inhibitors of angiogenesis
Abstract
Under physiological conditions, angiogenesis is regulated by the local balance between endogenous stimulators and inhibitors of this process. In pathological states such as chronic inflammation and tumor growth, there is an imbalance between endogenous stimulator and inhibitor levels, leading to an "angiogenic switch". Various inhibitors of angiogenesis, including angiostatin, endostatin and thrombospondins, are found in the body. It is uncertain why the body possesses so many inhibitors, and also how these inhibitors interact to overcome the effects of angiogenesis stimulators. This review summarizes the present knowledge about endogenous inhibitors of angiogenesis.
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The C-terminal non-collagenous (NC1) domain of collagen has been reported as an inhibitor of angiogenesis.
“The C-terminal non-collagenous (NC1) domain of the collagen has been reported as an inhibitor of angiogenesis (29–31).”
From Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration (2011) · cites this paper as [31]
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References 99 · Cited by 191
- Authors
- Ribatti, D.
- Venue
- Leukemia Research
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 33
- Issue
- 5
- Pages
- 638-644
- ISSN
- 0145-2126 (ISSN-L)
- OpenAlex
- W198469451
- Cited by
- 191
- References
- 99
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 8 · 2019: 11 · 2018: 6 · 2017: 18 · 2016: 11 · 2015: 10 · 2014: 19 · 2013: 18 · 2012: 20
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Leukemia Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Health Sciences › Medicine › Oncology › Vascular Tumors and Angiosarcomas
- Keywords
- angiogenesis inhibitors, angiogenic switch, angiostatin, endostatin, thrombospondin, chronic inflammation, tumor growth, angiogenesis regulators
- MeSH terms
- Humans, Neoplasms, Neovascularization, Pathologic
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