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miR-138 might reverse multidrug resistance of leukemia cells

Zhao, Xiaohong, Yang, Li, Hu, Jianguo, Ruan, Jigang·2010·Leukemia Research
DOI 10.1016/j.leukres.2009.10.002
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Abstract

Here we firstly investigated the role of miR-138 in multidrug resistance of leukemia cells. miR-138 was found up-regulated in the vincristine-induced multidrug resistance (MDR) leukemia cell line HL-60/VCR as compared with HL-60 cells. Up-regulation of miR-138 could reverse resistance of both P-glycoprotein-related and P-glycoprotein-non-related drugs on HL-60/VCR cells, and promote adriamycin-induced apoptosis, accompanied by increased accumulation and decreased releasing amount of adriamycin. miR-138 could significantly down-regulate the expression of P-glycoprotein, Bcl-2, and the transcription of the multidrug resistance gene 1. Further study of the biological functions of miR-138 might be helpful for developing possible strategies to treat leukemia.

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Research works printed but not linked: 19

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Metadata

Authors
Zhao, X., Yang, L., Hu, J., & Ruan, J.
Venue
Leukemia Research
Publisher
Elsevier BV
Published
2010-08
Volume
34
Issue
8
Pages
1078-1082
ISSN
0145-2126
DOI
10.1016/j.leukres.2009.10.002
Cited by
79
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
National Scientific Foundation of China (30770641)

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CoChat. (2026). Citation check: miR-138 might reverse multidrug resistance of leukemia cells. https://app.cochat.ai/papers/10.1016/j.leukres.2009.10.002
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Zhao, X., Yang, L., Hu, J., & Ruan, J. (2010). miR-138 might reverse multidrug resistance of leukemia cells. Leukemia Research. https://doi.org/10.1016/j.leukres.2009.10.002