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Germline predisposition to clonal hematopoiesis

Liu, Jie, Osman, Afaf E.G., Bolton, Kelly, Godley, Lucy A.·2023·Leukemia Research
DOI 10.1016/j.leukres.2023.107344
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Abstract

We now recognize that with aging, hematopoietic stem and progenitor cells (HSPCs) acquire mutations that confer a fitness advantage and clonally expand in a process now termed clonal hematopoiesis (CH). Because CH predisposes to a variety of health problems, including cancers, cardiovascular diseases, and inflammatory conditions, there is intense interest in the inherited alleles associated with the development of CH. DNA variants near TERT, SMC4, KPNA4, IL12A, CD164, and ATM confer the strongest associations. In this review, we discuss our current state of knowledge regarding germline predisposition to CH.

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Metadata

Authors
Liu, J., Osman, A. E. G., Bolton, K., & Godley, L. A.
Venue
Leukemia Research
Publisher
Elsevier BV
Published
2023-09
Volume
132
Pages
107344
ISSN
0145-2126
DOI
10.1016/j.leukres.2023.107344
Cited by
7
References
6
Language
en
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CoChat. (2026). Citation check: Germline predisposition to clonal hematopoiesis. https://app.cochat.ai/papers/10.1016/j.leukres.2023.107344
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Liu, J., Osman, A. E. G., Bolton, K., & Godley, L. A. (2023). Germline predisposition to clonal hematopoiesis. Leukemia Research. https://doi.org/10.1016/j.leukres.2023.107344