The DOI matches its Crossref record; 70 of the 71 references it cites were found in a registry or an index.
Chemical constituents of marijuana: The complex mixture of natural cannabinoids
Abstract
The cannabis plant (Cannabis sativa L.) and products thereof (such as marijuana, hashish and hash oil) have a long history of use both as a medicinal agent and intoxicant. Over the last few years there have been an active debate regarding the medicinal aspects of cannabis. Currently cannabis products are classified as Schedule I drugs under the Drug Enforcement Administration (DEA) Controlled Substances act, which means that the drug is only available for human use as an investigational drug. In addition to the social aspects of the use of the drug and its abuse potential, the issue of approving it as a medicine is further complicated by the complexity of the chemical make up of the plant. This manuscript discusses the chemical constituents of the plant with particular emphasis on the cannabinoids as the class of compounds responsible for the drug's psychological properties.
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In the citing paper
“While cannabinoids, such as tetrahydrocannabinol (THC) and cannabidiol (CBD), dominate the current understanding of Cannabis bioactivity, other specialized metabolites—including alkaloids, flavonoids, and stilbenes—also contribute to its pharmacological profile but remain less studied [2,9,10].”
In the citing paper
“More than 90 different cannabinoids have been reported in the literature, although some of these are breakdown products (ElSohly and Slade, 2005; Brenneisen, 2007; Radwan et al., 2009; Fischedick et al., 2010) and they are generally classified into 10 subclasses (Brenneisen, 2007).”
From Cannabis sativa: The Plant of the Thousand and One Molecules (2016) · cites this paper as ElSohly and Slade, 2005
Citations
Cites
Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish
Gaoni, Y., & Mechoulam, R. (1964) · Journal of the American Chemical Society · doi:10.1021/ja01062a046 · Cited by 2,389
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Gaoni, Y., & Mechoulam, R. (1971) · Journal of the American Chemical Society · doi:10.1021/ja00730a036 · Cited by 364
Chemical Basis of Hashish Activity
Mechoulam, R., Shani, A., Edery, H., & Grunfeld, Y. (1970) · Science · doi:10.1126/science.169.3945.611 · Cited by 331
Structure of Cannabidiol, a Product Isolated from the Marihuana Extract of Minnesota Wild Hemp. I
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Flagged first, then by citations
1 of the 71 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Gaoni, 1964, Structure and synthesis of cannabigerol, a new hashish constituent, Proceedings of the Chemical Society, 82
- Morita, 1984, Analysis of hashish oil by gas chromatography/mass spectrometry, Kagaku Keisatsu Kenkyujo Hokoku. Hokagaku-Hen, 37, 137
- Pate, D. 1999. Anandamide structure-activity relationships and mechanisms of action on intraocular pressure in the normotensive rabbit model. Ph.D. thesis, University of Kuopio, Kuopio, Finland.
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Cannabis sativa: The Plant of the Thousand and One Molecules
Andre, C. M., Hausman, J.-F., & Guerriero, G. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00019 · Cited by 1,544
“More than 90 different cannabinoids have been reported in the literature, although some of these are breakdown products (ElSohly and Slade, 2005; Brenneisen, 2007; Radwan et al., 2009; Fischedick et al., 2010) and they are generally classified into 10 subclasses (Brenneisen, 2007).”
BackgroundDe Petrocellis, L., Ligresti, A., Moriello, A. S., Allarà, M., Bisogno, T., Petrosino, S., Stott, C. G., & Di Marzo, V. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01166.x · Cited by 946
Phytocannabinoids: a unified critical inventory
Hanuš, L. O., Meyer, S. M., Muñoz, E., Taglialatela-Scafati, O., & Appendino, G. (2016) · Natural Product Reports · doi:10.1039/c6np00074f · Cited by 844
Antioxidative and Anti-Inflammatory Properties of Cannabidiol
Atalay, S., Jarocka-Karpowicz, I., & Skrzydlewska, E. (2019) · Antioxidants · doi:10.3390/antiox9010021 · Cited by 889
Thomas, A., Baillie, G. L., Phillips, A. M., Razdan, R. K., Ross, R. A., & Pertwee, R. G. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707133 · Cited by 763
Metadata
- Authors
- ElSohly, M. A., & Slade, D.
- Affiliations
- University of Mississippi (US)
- Corresponding author
- ElSohly, Mahmoud A.
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 78
- Issue
- 5
- Pages
- 539-548
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2114062911
- Cited by
- 1,094
- References
- 71
- Citations by year
- 2026: 33 · 2025: 60 · 2024: 69 · 2023: 104 · 2022: 82 · 2021: 116 · 2020: 90 · 2019: 82 · 2018: 70 · 2017: 55 · 2016: 56 · 2015: 52 · 2014: 35 · 2013: 28 · 2012: 35
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Life Sciences › Agricultural and Biological Sciences › Food Science › Hops Chemistry and Applications
- Keywords
- cannabinoids, Cannabis sativa, cannabis, hashish, chemical constituents, medical cannabis, Schedule I drug classification, psychoactive effects
- MeSH terms
- Cannabinoids, Cannabis, Complex Mixtures
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