Chemogenetic stimulation of the parasympathetic nervous system lowers hepatic lipid accumulation and inflammation in a nonalcoholic steatohepatitis mouse model

Hur, Moon Haeng; Song, Woojin; Cheon, Deok-Hyeon; Chang, Young; Cho, Young Youn; Lee, Yun Bin; Yu, Su Jong; Kim, Yoon Jun; Yoon, Jung-Hwan; Choi, Hyung Jin; NamKoong, Cherl; Lee, Jeong-Hoon

doi:10.1016/j.lfs.2023.121533

Chemogenetic stimulation of the parasympathetic nervous system lowers hepatic lipid accumulation and inflammation in a nonalcoholic steatohepatitis mouse model

AIMS The role of the parasympathetic nervous system (PNS) in the pathogenesis of nonalcoholic steatohepatitis (NASH) is largely unknown. In this study, the effect of PNS modulation on NASH was investigated using chemogenetics. MAIN METHODS A streptozotocin (STZ) and high-fat diet (HFD)-induced NA…