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Cited by 8Effects of Radiation ExposureSpaceflight effects on biologyRadiation Therapy and Dosimetry

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Angiotensin converting enzyme (ACE) inhibitors as radiation countermeasures for long-duration space flights

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Moulder, John E., Cohen, Eric P., Medhora, Meetha, Fish, Brian L.·2022·Life Sciences in Space Research
DOI 10.1016/j.lssr.2022.04.005
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Abstract

Angiotensin converting enzyme (ACE) inhibitors are effective countermeasures to chronic radiation injuries in rodent models, and there is evidence for similar effects in humans. In rodent models ACE inhibitors are effective mitigators of radiation injury to kidney, lung, central nervous system (CNS) and skin, even when started weeks after irradiation. In humans, the best data for their efficacy as radiation countermeasures comes from retrospective studies of injuries in radiotherapy patients. We propose that ACE inhibitors, at doses approved for human use for other indications, could be used to reduce the risk of chronic radiation injuries from deep-space exploration. Because of the potential interaction of ACE inhibitors and microgravity (due to effects of ACE inhibitors on fluid balance) use might be restricted to post-exposure when/if radiation exposures reached a danger level. A major unresolved issue for this approach is the sparse evidence for the efficacy of ACE inhibitors after low-dose-rate exposure and/or for high-LET radiations (as would occur on long-duration space flights). A second issue is that the lack of a clear mechanism of action of the ACE inhibitors as mitigators makes obtaining an appropriate label under the Food and Drug Administration Animal Rule difficult.

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Research works printed but not linked: 107

  1. Aebersold, 2012, FDA experience with medical countermeasures under the animal rule, Adv. Prev. Med, 2012, 10.1155/2012/507571 · DOI
  2. Alashkham, 2016, Can angiotensin-converting enzyme inhibitors reduce the incidence, severity, and duration of radiation proctitis?, Int. J. Radiat. Oncol. Biol. Phys, 94, 93, 10.1016/j.ijrobp.2015.09.013 · DOI
  3. Alite, 2018, Decreased risk of radiation pneumonitis with coincident concurrent use of angiotensin-converting enzyme inhibitors in patients receiving lung stereotactic body radiation therapy, Am. J. Clin. Oncol., 41, 576, 10.1097/COC.0000000000000324 · DOI
  4. Barshishat-Kupper, 2011, Captopril modulates hypoxia-inducible factors and erythropoietin responses in a murine model of total body irradiation, Exp. Hematol., 39, 293, 10.1016/j.exphem.2010.12.002 · DOI
  5. Bezjak, 2005, Radiation pneumonitis in lung cancer patients - the neglected patient-related variables, Int. J. Radiat. Oncol. Biol. Phys, 63, S229, 10.1016/j.ijrobp.2005.07.391 · DOI
  6. Bracci, 2016, Renin-angiotensin system inhibitors might help to reduce the development of symptomatic radiation pneumonitis after stereotactic body radiotherapy for lung cancer, Clin. Lung Cancer, 17, 189, 10.1016/j.cllc.2015.08.007 · DOI
  7. Chancellor, 2018, Limitations in predicting the space radiation health risk for exploration astronauts, NPJ Microgravity, 4, 10.1038/s41526-018-0043-2 · DOI · Paper page
  8. Charrier, 2004, Inhibition of angiotensin I-converting enzyme induces radioprotection by preserving murine hematopoietic short-term reconstituting cells, Blood, 104, 978, 10.1182/blood-2003-11-3828 · DOI
  9. Chen, 2021, Comparative first-line effectiveness and safety of ACE (angiotensin-converting enzyme) inhibitors and angiotensin receptor blockers: a multinational cohort study, Hypertension, 78, 591, 10.1161/HYPERTENSIONAHA.120.16667 · DOI · Paper page
  10. Chowdhary, 2018, Angiotensin receptor blockade: a novel approach for symptomatic radiation necrosis after stereotactic radiosurgery, J. Neurooncol., 136, 289, 10.1007/s11060-017-2652-0 · DOI
  11. Chundury, 2015, Radiation pneumonitis with stereotactic body radiotherapy; effect of angiotensin converting enzyme inhibitors, Radiother. Oncol., S208, 10.1016/S0167-8140(15)40424-4 · DOI
  12. Clausi, 2018, Mitigation of radiation myelopathy and reduction of microglial infiltration by ramipril, ACE inhibitor, Spinal Cord, 56, 733, 10.1038/s41393-018-0158-z · DOI
  13. Cohen, 2012, Mitigation of late renal and pulmonary injury after hematopoietic stem cell transplantation, Int. J. Radiat. Oncol. Biol. Phys, 83, 292, 10.1016/j.ijrobp.2011.05.081 · DOI
  14. Cohen, 2015, Mitigation of normal tissue radiation injury: evidence from rat radiation nephropathy models, J. Radiat. Oncol, 3, 1
  15. Cohen, 1992, Treatment of radiation nephropathy with captopril, Radiat. Res., 132, 346, 10.2307/3578243 · DOI
  16. Cohen, 1997, Successful brief captopril treatment in radiation nephropathy, J. Lab. Clin. Med, 129, 536, 10.1016/S0022-2143(97)90008-1 · DOI
  17. Cohen, 2010, Mitigation of radiation injuries via suppression of the renin-angiotensin system: emphasis on radiation nephropathy, Curr. Drug Targets, 11, 1423, 10.2174/1389450111009011423 · DOI
  18. Cohen, 2003, Successful treatment of radiation nephropathy with angiotensin II blockade, Int. J. Radiat. Oncol. Biol. Phys, 55, 190, 10.1016/S0360-3016(02)03793-8 · DOI
  19. Cohen, 2008, Captopril to mitigate chronic renal failure after hematopoietic stem cell transplantation: a randomized controlled trial, Int. J. Radiat. Oncol. Biol. Phys, 70, 1546, 10.1016/j.ijrobp.2007.08.041 · DOI
  20. Cohen, 1994, Prophylaxis of experimental bone marrow transplant nephropathy, J. Lab. Clin. Med, 124, 371
  21. Cucinotta, 1999, Issues in risk assessment from solar particle events, Radiat. Meas, 30, 261, 10.1016/S1350-4487(99)00054-2 · DOI
  22. Davis, 2010, Timing of captopril administration determines radiation protection or radiation sensitization in a murine model of total body irradiation, Exp. Hematol., 38, 270, 10.1016/j.exphem.2010.01.004 · DOI
  23. Davis T.A., Landauer M.R., Mog S.R., Barshishat-Kupper M., Zins S.R., Amare M.F. Response to Moulder et al., ‘‘Re: Davis et al., ‘Timing of captopril administration determines radiation protection or radiation sensitization in a murine model of total body irradiation’’’. 2011;39:521–524. 10.1016/j.exphem.2011.02.007. · DOI
  24. Day, 2013, Enhanced hematopoietic protection from radiation by the combination of genistein and captopril, Int. Immunopharmacol, 15, 348, 10.1016/j.intimp.2012.12.029 · DOI
  25. DiCarlo, 2022, Inter-agency perspective: translating advances in biomarker discovery and medical countermeasures development for terrestrial radiation exposures into the NASA mission space, Life Sci. Space Res. (Amst), 35, 60
  26. Erpolat, 2020, A comparison of ramipril and bevacizumab to mitigate radiation-induced brain necrosis: an experimental study, World Neurosurg, 144, E210, 10.1016/j.wneu.2020.08.081 · DOI
  27. Fish, 2016, Combined hydration and antibiotics with lisinopril to mitigate acute and delayed high-dose radiation injuries to multiple organs, Health Phys, 111, 410, 10.1097/HP.0000000000000554 · DOI
  28. Fish, 2021, Rat models of partial-body irradiation with bone marrow-sparing (leg-out PBI) designed for FDA approval of countermeasures for mitigation of acute and delayed injuries by radiation, Health Phys, 121, 419, 10.1097/HP.0000000000001444 · DOI
  29. Fish, 2020, WAG/RijCmcr rat models for injuries to multiple organs by single high dose ionizing radiation: similarities to non- human primates (NHP), Int. J. Radiat. Biol., 96, 81, 10.1080/09553002.2018.1554921 · DOI
  30. Gao, 2013, Enalapril mitigates radiation-induced pneumonitis and pulmonary fibrosis if started 35 days after whole-thorax irradiation, Radiat. Res., 180, 546, 10.1667/RR13350.1 · DOI
  31. Gao, 2014, Enhanced survival from radiation pneumonitis by combined irradiation to the skin, Int. J. Radiat. Biol., 90, 751, 10.3109/09553002.2014.922722 · DOI
  32. Gasperetti, 2021, Polypharmacy to mitigate acute and delayed radiation syndromes, Front. Pharmacol, 12
  33. Geraci, 1995, Amelioration of radiation nephropathy in rats by postirradiation treatment with dexamethasone and/or captopril, Radiat. Res., 143, 58, 10.2307/3578926 · DOI
  34. Ghosh, 2009, Renin-angiotensin system suppression mitigates experimental radiation pneumonitis, Int. J. Radiat. Oncol. Biol. Phys, 75, 1528, 10.1016/j.ijrobp.2009.07.1743 · DOI
  35. Harder, 2015, Angiotensin-converting enzyme inhibitors decrease the risk of radiation pneumonitis after stereotactic body radiation therapy, Pract. Radiat. Oncol, 5, e643, 10.1016/j.prro.2015.07.003 · DOI
  36. Hosseinimehr, 2007, Captopril protects mice bone marrow cells against genotoxicity induced by gamma irradiation, Cell Biochem. Funct., 25, 389, 10.1002/cbf.1311 · DOI
  37. Hsia, 2015, Effect of diabetes mellitus and selected medications on the development of radiation pneumonitis in patients with locally advanced non-small cell lung cancer, Int. J. Radiat. Oncol. Biol. Phys, 93, E403, 10.1016/j.ijrobp.2015.07.1576 · DOI
  38. Islam, 2015, Captopril increases survival after whole-body ionizing irradiation but decreases survival when combined with skin-burn trauma in mice, Radiat. Res., 184, 273, 10.1667/RR14113.1 · DOI
  39. Jacobs, 2019, Cardiac remodeling and reversible pulmonary hypertension during pneumonitis in rats after 13-Gy partial-body irradiation with minimal bone marrow sparing: effect of lisinopril, Health Phys, 116, 558, 10.1097/HP.0000000000000919 · DOI
  40. Jenkins, 2009, Angiotensin converting enzyme inhibitors (ACE-I) protect against the clinical and radiological manifestations of radiation pneumonitis (RP) in patients undergoing radical radiotherapy for lung cancer, Eur. J. Cancer, 7, 152, 10.1016/S1359-6349(09)70519-1 · DOI
  41. Jenrow, 2010, Ramipril mitigates radiation-induced impairment of neurogenesis in the rat dentate gyrus, Radiat. Oncol, 5, 10.1186/1748-717X-5-6 · DOI
  42. Juncos, 1993, Long-term enalapril and hydrochlorothiazide in radiation nephritis, Nephron, 64, 249, 10.1159/000187322 · DOI
  43. Kharofa, 2013, Symptomatic radiation pneumonitis in elderly patients receiving thoracic irradiation, Clin. Lung Cancer, 14, 283, 10.1016/j.cllc.2012.10.005 · DOI
  44. Kharofa, 2012, Decreased risk of radiation pneumonitis with incidental concurrent use of angiotensin-converting enzyme inhibitors and thoracic radiation therapy, Int. J. Radiat. Oncol. Biol. Phys, 84, 238, 10.1016/j.ijrobp.2011.11.013 · DOI
  45. Kim, 2004, Modification of radiation injury by ramipril, inhibitor of angiotensin converting enzyme, on optic neuropathy in the rat, Radiat. Res., 161, 137, 10.1667/RR3124 · DOI
  46. Kma, 2012, Angiotensin converting enzyme inhibitors mitigate collagen synthesis induced by a single dose of radiation to the whole thorax, J. Radiat. Res., 32, 10, 10.1269/jrr.11035 · DOI
  47. Kohl, 2007, Differential radiation effect in tumor and normal tissue after treatment with ramipril, an angiotensin-converting enzyme inhibitor, Radiat. Res., 168, 440, 10.1667/RR0707.1 · DOI
  48. Kokhan, 2016, Risk of defects in the central nervous system during deep space missions, Neurosci. Biobehav. Rev, 71, 621, 10.1016/j.neubiorev.2016.10.006 · DOI
  49. Kronenberg, 2012, Space radiation protection issues, Health Phys, 103, 556, 10.1097/HP.0b013e3182690caf · DOI
  50. Lee, 2012, Chronic administration of the angiotensin-converting enzyme inhibitor, ramipril, prevents fractionated whole-brain irradiation-induced perirhinal cortex-dependent cognitive impairment, Radiat. Res., 178, 46, 10.1667/RR2731.1 · DOI
  51. Lenarczyk, 2013, Cardiac injury following 10 Gy total body irradiation: indirect role of effects on abdominal organs, Radiat. Res., 180, 247, 10.1667/RR3292.1 · DOI
  52. Lewis, 1993, The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy, N. Engl. J. Med, 329, 1456, 10.1056/NEJM199311113292004 · DOI · Paper page
  53. Liu, 2015, Involvement of renin-angiotensin system in damage of angiotensin-converting enzyme inhibitor captopril on bone of normal mice, Biol. Pharm. Bull, 38, 869, 10.1248/bpb.b14-00829 · DOI
  54. Mason, 2000, Safety and costs of initiating angiotensin converting enzyme inhibitors for heart failure in primary care: analysis of individual patient data from studies of left ventricular dysfunction, BMJ, 321, 1113, 10.1136/bmj.321.7269.1113 · DOI
  55. McFate Smith, 1984, Tolerance and safety of enalapril, Br. J. Clin. Pharmacol, 18, 249S
  56. Medhora, 2012, Dose-modifying factor for captopril for mitigation of radiation injury to normal lung, J. Radiat. Res., 53, 633, 10.1093/jrr/rrs004 · DOI
  57. Medhora, 2019, Delayed effects of acute radiation exposure (DEARE) in juvenile and old rats: mitigation by lisinopril, Health Phys, 116, 529, 10.1097/HP.0000000000000920 · DOI
  58. Medhora, 2014, Model development and use of ACE inhibitors for preclinical mitigation of radiation-induced injury to multiple organs, Radiat. Res., 182, 545, 10.1667/RR13425.1 · DOI
  59. Meerman, 2021, Myocardial disease and long-distance space travel: solving the radiation problem, Front. Cardiovas. Med, 8, 10.3389/fcvm.2021.631985 · DOI
  60. Molteni, 2006, Potential deployment of angiotensin converting enzyme inhibitors and of angiotensin 2 type 1 and type 2 receptor blockers in cancer chemotherapy, Anticancer Agents Med. Chem, 6, 451, 10.2174/187152006778226521 · DOI
  61. Molteni, 2000, Control of radiation-induced pneumopathy and lung fibrosis by angiotensin converting enzyme inhibitors and an angiotensin II type 1 receptor blocker, Int. J. Radiat. Biol., 76, 523, 10.1080/095530000138538 · DOI
  62. Molthen, 2012, Mitigation of radiation induced pulmonary vascular injury by delayed treatment with captopril, Respirology, 17, 1261, 10.1111/j.1440-1843.2012.02247.x · DOI
  63. Moulder, 2011, Captopril and losartan for mitigation of renal injury caused by single-dose total body irradiation, Radiat. Res., 175, 29, 10.1667/RR2400.1 · DOI
  64. Moulder, 2014, Mitigation of experimental radiation nephropathy by renin-equivalent doses of angiotensin converting enzyme inhibitors, Int. J. Radiat. Biol, 90, 762, 10.3109/09553002.2014.938375 · DOI
  65. Moulder, 1993, Prophylaxis of bone marrow transplant nephropathy with captopril, an inhibitor of angiotensin-converting enzyme, Radiat. Res., 136, 404, 10.2307/3578554 · DOI
  66. Moulder, 1997, Angiotensin converting enzyme inhibitor captopril does not prevent acute gastrointestinal radiation damage in the rat, Radiat. Oncol. Investig, 5, 50, 10.1002/(SICI)1520-6823(1997)5:2<50::AID-ROI2>3.0.CO;2-I · DOI
  67. Moulder, 2011, : Davis et al., Timing of captopril administration determines radiation protection or radiation sensitization in a murine model of total body irradiation, Exp. Hematol., 39, 521, 10.1016/j.exphem.2011.02.006 · DOI
  68. Moulder, 1993, Treatment of radiation nephropathy with ACE inhibitors, Int. J. Radiat. Oncol. Biol. Phys, 27, 93, 10.1016/0360-3016(93)90425-U · DOI
  69. Moulder J.E., Fish B.L., Cohen E.P. Noncontinuous use of angiotensin converting enzyme inhibitors in the treatment of experimental bone marrow transplant nephropathy. cf. 1997;19:729–736. 10.1038/sj.bmt.1700732. · DOI
  70. Moulder, 1998, Brief pharmacologic intervention in experimental radiation nephropathy, Radiat. Res., 150, 535, 10.2307/3579870 · DOI
  71. Moulder, 1998, Radiation nephropathy is treatable with an angiotensin converting enzyme inhibitor or an angiotensin II type-1 (AT1) receptor antagonist, Radiother. Oncol, 46, 307, 10.1016/S0167-8140(97)00175-8 · DOI
  72. Moulder, 2007, Treatment of radiation nephropathy with ACE inhibitors and AII type-1 and type-2 receptor antagonists, Curr. Pharm. Design, 13, 1317, 10.2174/138161207780618821 · DOI
  73. Moulder, 2003, Pharmacological intervention to prevent or ameliorate chronic radiation injuries, Semin Radiat. Oncol, 13, 73, 10.1053/srao.2003.50007 · DOI
  74. Moulder, 2013, Dade W. Moeller lecture: medical countermeasures against radiological terrorism, Health Phys, 107, 164, 10.1097/HP.0000000000000082 · DOI
  75. Naftalin, 2004, Alterations in colonic barrier function caused by a low sodium diet or ionizing radiation, J. Environ. Pathol. Toxicol. Oncol, 23, 79, 10.1615/JEnvPathToxOncol.v23.i2.10 · DOI
  76. Nelson, 2016, Space radiation and human exposures, a primer, Radiat. Res., 185, 349, 10.1667/RR14311.1 · DOI
  77. Otterson, 2012, Safety of enalapril after abdominal irradiation, J. Investig. Med, 60, 726
  78. Patel, 2020, The effects of microgravity and space radiation on cardiovascular health: from low-Earth orbit and beyond, Int. J. Cardiol. - Heart Vascular, 30
  79. Pinter, 2018, Renin-angiotensin system inhibitors to mitigate cancer treatment-related adverse events, Clin. Cancer Res, 24, 3803, 10.1158/1078-0432.CCR-18-0236 · DOI
  80. Price, 2018, Challenges and benefits of repurposing licensed/approved/cleared products for a radiation indication, Radiat. Res., 190, 654, 10.1667/RR15138.1 · DOI
  81. Regulska, 2013, The renin-angiotensin system as a target of novel anticancer therapy, Curr. Pharm. Design, 19, 7103, 10.2174/13816128113199990508 · DOI
  82. Rengo, 1995, Comparison of the safety and efficacy of delapril with enalapril in patients with congestive heart failure, Am. J. Cardiol, 75, 25F, 10.1016/S0002-9149(99)80511-6 · DOI
  83. Rivera, 2013, Acute and fractionated exposure to high-LET 56Fe HZE-particle radiation both result in similar long-term deficits in adult hippocampal neurogenesis, Radiat. Res., 180, 658, 10.1667/RR13480.1 · DOI
  84. Robbins, 1986, Physiological factors effecting renal radiation tolerance: a guide to the treatment of late effects, Br. J. Cancer, 53, 265
  85. Ryu, 2007, Mitigation of radiation-induced optic neuropathy in rats by ACE inhibitor ramipril: importance of ramipril dose and treatment time, J. Neurooncol., 82, 119, 10.1007/s11060-006-9256-4 · DOI
  86. Saager, 2020, Ramipril reduces incidence and prolongates latency time of radiation-induced rat myelopathy after photon and carbon ion irradiation, J. Radiat. Res., 61, 791, 10.1093/jrr/rraa042 · DOI
  87. Saunders, 2021, Long-acting PGE2 and Lisinopril mitigate H-ARS, Radiat. Res, 196, 284, 10.1667/RADE-20-00113.1 · DOI
  88. Schoolwerth, 2001, Renal considerations in angiotensin converting enzyme inhibitor therapy: a statement for healthcare professionals from the council on the kidney in cardiovascular disease and the council for high blood pressure research of the American heart association, Circulation., 104, 1985, 10.1161/hc4101.096153 · DOI
  89. Singh, 2017, Nonhuman primates as models for the discovery and development of radiation countermeasures, Expert Opin. Drug Discov, 12, 695, 10.1080/17460441.2017.1323863 · DOI
  90. Singh, 2021, Repurposing pharmaceuticals previously approved by regulatory agencies to medically counter injuries arising either early or late following radiation exposure, Front. Pharmacol, 12, 10.3389/fphar.2021.624844 · DOI
  91. Sio, 2019, Daily lisinopril vs placebo for prevention of phemoradiation-induced pulmonary distress in patients with lung cancer (Alliance MC1221): a pilot double-blind randomized trial, Int. J. Radiat. Oncol. Biol. Phys, 103, 686, 10.1016/j.ijrobp.2018.10.035 · DOI
  92. Small, 2018, Utility of the ACE inhibitor captopril in mitigating radiation-associated pulmonary toxicity in lung cancer: results from NRG oncology RTOG 0123, Am. J. Clin. Oncol., 41, 396, 10.1097/COC.0000000000000289 · DOI
  93. Spotheim-Maurizot, 1993, N-acetylcysteine and captopril protect DNA and cells against radiolysis by fast neutrons, Radiat. Environ. Biophys, 32, 337, 10.1007/BF01225921 · DOI
  94. Stone, 2004, Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI workshop, December 3-4, 2003, Radiat. Res., 162, 711, 10.1667/RR3276 · DOI
  95. Sweet, 2014, Central nervous system effects of whole-body proton irradiation, Radiat. Res., 182, 18, 10.1667/RR13699.1 · DOI
  96. Unthank, 2019, Cardiac and renal delayed effects of acute radiation exposure: organ oifferences in oasculopathy, inflammation, senescence and oxidative balance, Radiat. Res., 191, 383, 10.1667/RR15130.1 · DOI
  97. van der Veen, 2015, ACE inhibition attenuates radiation-induced cardiopulmonary damage, Radiother. Oncol, 114, 96, 10.1016/j.radonc.2014.11.017 · DOI
  98. Vernice, 2020, Long-term spaceflight and the cardiovascular system, Precision Clin. Med, 3, 284, 10.1093/pcmedi/pbaa022 · DOI
  99. Wang, 2013, Do Angiotensin-converting enzyme inhibitors reduce the risk of symptomatic radiation pneumonitis in patients with non-small cell lung cancer after definitive radiation therapy? Analysis of a single-institution database, Int. J. Radiat. Oncol. Biol. Phys., 87, 1071, 10.1016/j.ijrobp.2013.08.033 · DOI
  100. Wang, 2000, Can angiotensin-converting enzyme inhibitors protect against symptomatic radiation pneumonitis?, Radiat. Res., 153, 405, 10.1667/0033-7587(2000)153[0405:CACEIP]2.0.CO;2 · DOI
  101. Ward, 1988, Radiation-induced pulmonary endothelial dysfunction in rats: modification by an inhibitor of angiotensin converting enzyme, Int. J. Radiat. Oncol. Biol. Phys, 15, 135, 10.1016/0360-3016(88)90357-4 · DOI
  102. Ward, 1990, The effect of captopril on benign and malignant reactions in irradiated rat skin, Br. J. Radiol, 63, 349, 10.1259/0007-1285-63-749-349 · DOI
  103. Ward, 1992, Radiation pneumotoxicity in rats: modification by inhibitors of angiotensin converting enzyme, Int. J. Radiat. Oncol. Biol. Phys, 22, 623, 10.1016/0360-3016(92)90890-T · DOI
  104. Wedlake, 2012, Evaluating the efficacy of statins and ACE-inhibitors in reducing gastrointestinal toxicity in patients receiving radiotherapy for pelvic malignancies, Eur. J. Cancer, 48, 2117, 10.1016/j.ejca.2011.12.034 · DOI
  105. Yarom, 1993, Effect of captopril on changes in rats’ hearts induced by long-term irradiation, Radiat. Res., 133, 187, 10.2307/3578356 · DOI
  106. Yoon, 1994, Radioprotective effect of captopril on the mouse jejunal mucosa, Int. J. Radiat. Oncol. Biol. Phys, 30, 873, 10.1016/0360-3016(94)90363-8 · DOI
  107. Zhang, 2015, The clinical preventive effect of angiotensin converting enzyme inhibitor in radiation pneumonitis, Acta Acad. Med. Weifang (潍坊医学院学报), 37, 395

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Metadata

Authors
Moulder, J. E., Cohen, E. P., Medhora, M., & Fish, B. L.
Affiliations
  • Medical College of Wisconsin (US)
  • NYU Langone Health (US)
Corresponding author
Cohen, Eric P.
ORCID
Venue
Life Sciences in Space Research
Publisher
Elsevier BV
Published
2022-11
Volume
35
Pages
60-68
ISSN
2214-5524 (ISSN-L)
DOI
10.1016/j.lssr.2022.04.005
OpenAlex
W4224252939
Cited by
8
References
3
Citations by year
2025: 4 · 2024: 1 · 2023: 2 · 2022: 1
FWCI
1.14
Type
journal article
Language
en
Open access
Licence
Locations
  • Life Sciences in Space Research (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (AI067734, AI101898, AI107276, AI107305, AI133594, AI81294)
  • U.S. Department of Veterans Affairs (BX003833)
  • Biomedical Advanced Research and Development Authority (HHSO100205000091)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
  • Health Sciences › Medicine › Physiology (medical) › Spaceflight effects on biology
  • Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
Keywords
ACE inhibitors, radiation countermeasures, chronic radiation injury, long-duration spaceflight, deep space exploration, microgravity, fluid balance, radiation-induced lung injury, radiation dermatitis, radiotherapy patients, low-dose-rate exposure, high-LET radiation, FDA Animal Rule, rodent models
MeSH terms
Angiotensin-Converting Enzyme Inhibitors, Animals, Captopril, Humans, Peptidyl-Dipeptidase A, Radiation Injuries, Retrospective Studies, Space Flight

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