Antibiotics are associated with attenuated efficacy of anti-PD-1/PD-L1 therapies in Chinese patients with advanced non-small cell lung cancer

Zhao, Sha; Gao, Guanghui; Li, Wei; Li, Xuefei; Zhao, Chao; Jiang, Tao; Jia, Yijun; He, Yayi; Li, Aiwu; Su, Chunxia; Ren, Shengxiang; Chen, Xiaoxia; Zhou, Caicun

doi:10.1016/j.lungcan.2019.01.017

Antibiotics are associated with attenuated efficacy of anti-PD-1/PD-L1 therapies in Chinese patients with advanced non-small cell lung cancer

OBJECTIVES Gut microbiome plays a dominant role in modulating therapeutic efficacy of immune checkpoint inhibitors (ICIs) targeting the programmed cell death receptor/ligand-1 (PD-1/PD-L1) pathway, suggesting that co-administration of antibiotics (Abx), which might result in dysbacteriosis, can a…