Nutrition, diet and immunosenescence
Open accessAbstract
Ageing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease. This complex process affects both the innate and adaptive immune systems with a progressive decline in most immune cell populations and defects in activation resulting in loss of function. Although host genetics and environmental factors, such as stress, exercise and diet can impact on the onset or course of immunosenescence, the mechanisms involved are largely unknown. This review focusses on identifying the most significant aspects of immunosenescence and on the evidence that nutritional intervention might delay this process, and consequently improve the quality of life of the elderly.
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Several factors, such as genetics, nutrition, exercise, previous exposure to microorganisms, biological and cultural sex, and HCMV status, can influence immunosenescence.
“Several factors, such as genetics, nutrition, exercise, previous exposure to microorganisms, biological and cultural sex, and human cytomegalovirus (HCMV) status can influence immunosenescence (3, 6–11).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [11]
The main barrier to better clarity remains the wide heterogeneity among human beings, linked to different life-style and genetic factors that influence the rate of immunosenescence.
“The main barrier to better clarity remains the wide heterogeneity among human beings, linked to different life-style and genetic factors that influence the rate of immunosenescence (6, 10, 11, 82).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [11]
Many existing data demonstrate the key role of foods as regulators of immune response and inflammatory status, hence as possible modulators of the rate of immunosenescence, particularly inflamm-aging.
“Many existing data demonstrate the key role of foods as regulators of immune response and inflammatory status, hence as possible modulators of the rate of immunosenescence, particularly inflamm-aging (11, 80).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [11]
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References 216 · Cited by 85
Research works printed but not linked: 1
- Goronzy, J.J., Fulbright, J.W., Crowson, C.S., Poland, G.A., O'Fallon, W.M. and Weyand, C.M., 2001b. Value of Immunological Markers in Predicting Responsiveness to Influenza Vaccination in Elderly Individuals. Journal of Virology. 75, 12182-12187.
- Authors
- Maijó, M., Clements, S. J., Ivory, K., Nicoletti, C., & Carding, S. R.
- Affiliations
- Quadram Institute (GB)
- University of East Anglia (GB)
- Corresponding author
- Carding, Simon R.
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 136-137
- Pages
- 116-128
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W1983295335
- Cited by
- 85
- References
- 216
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 10 · 2021: 17 · 2020: 10 · 2019: 7 · 2018: 5 · 2017: 6 · 2016: 9 · 2015: 6 · 2014: 2
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- green
- ueaeprints.uea.ac.uk
- Locations
- Mechanisms of Ageing and Development (publishedVersion)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (acceptedVersion)
- Institutional Research Information System (University of Udine) (submittedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Funders
- EU-FP7 NU-AGE (266486)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- immunosenescence, aging, nutrition, diet, dietary intervention, innate immunity, adaptive immunity, chronic disease, infection susceptibility, quality of life in old age
- MeSH terms
- Aged, Aging, Antigen-Presenting Cells, Dendritic Cells, Diet, Fatty Acids, Feeding Behavior, Humans, Immune System, Immunity, Innate, Inflammation, Longevity, Quality of Life, Vitamins, Exercise, Cytokines, Nutritional Sciences
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