The DOI matches its Crossref record; 198 of the 198 references it cites were found in a registry or an index.
Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease
Open accessAbstract
The mitochondria is the major hub to convert energy for cellular processes. Dysregulation of mitochondrial function is one of the classical hallmarks of aging, and mitochondrial interventions have repeatedly been shown to improve outcomes in age-related diseases. Crucial to mitochondrial regulation is the dynamic nature of their network structure. Mitochondria separate and merge using fission and fusion processes in response to changes in energy and stress status. While many mitochondrial processes are already characterized in relation to aging, specific evidence in multicellular organisms causally linking mitochondrial dynamics to the regulation of lifespan is limited. There does exist, however, a large body of evidence connecting mitochondrial dynamics to other aging-related cellular processes and implicates them in a number of human diseases. Here, we discuss the mechanisms of mitochondrial fission and fusion, the current evidence of their role in aging of multicellular organisms, and how these connect to cell cycle regulation, quality control, and transmission of energy status. Finally, we discuss the current evidence implicating these processes in age-related human pathologies, such as neurodegenerative or cardio-metabolic diseases. We suggest that deeper understanding of the regulatory mechanisms within this system and downstream implications could benefit in understanding and intervention of these conditions.
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Acylated Ghrelin as a Multi-Targeted Therapy for Alzheimer's and Parkinson's Disease
Reich, N., & Hölscher, C. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.614828 · Cited by 48
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Metadata
- Authors
- Liu, Y. J., McIntyre, R. L., Janssens, G. E., & Houtkooper, R. H.
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 186
- Pages
- 111212
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W3003394141
- Cited by
- 334
- References
- 198
- FWCI
- 11.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Liu, Y. J., McIntyre, R. L., Janssens, G. E., & Houtkooper, R. H. (2020). Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease. Mechanisms of Ageing and Development. https://doi.org/10.1016/j.mad.2020.111212
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
