Therapeutic applications of PARP inhibitors: Anticancer therapy and beyond

Curtin, Nicola J., Szabo, Csaba·2013·Molecular Aspects of Medicine

DOI 10.1016/j.mam.2013.01.006

Cites (559)

Items 201–400 of 551

Purines inhibit poly(ADP‐ribose) polymerase activation and modulate oxidant‐induced cell death
László Virág, Csaba Szabó · 2001 · The FASEB Journal
The response of Parp knockout mice against DNA damaging agents
Mitsuko Masutani, Tadashige Nozaki, Kentaro Nakamoto, Hitoshi Nakagama, Hiroshi I. Suzuki, Osamu Kusuoka, Masahiro Tsutsumi, Takashi Sugimura · 2000 · Mutation Research/Reviews in Mutation Research
Impaired mitochondrial function induced by serum from septic shock patients is attenuated by inhibition of nitric oxide synthase and poly(ADP-ribose) synthase*
Michael Boulos, Mark E. Astiz, Rajat S. Barua, Mohammed Osman · 2003 · Critical Care Medicine
Tricarboxylic Acid Cycle Substrates Prevent PARP-Mediated Death of Neurons and Astrocytes
Weihai Ying, Yongmei Chen, Conrad C. Alano, Raymond A. Swanson · 2002 · Journal of Cerebral Blood Flow & Metabolism
Poly(ADP-Ribose) Polymerase Impairs Early and Long-Term Experimental Stroke Recovery
Shozo Goto, Rong Xue, Nobuo Sugo, Masahiko Sawada, Kathleen K. Blizzard, Marc F. Poitras, David C. Johns, Ted M. Dawson, Valina Lynn Dawson, Barbara J. Crain et al. · 2002 · Stroke
PATHOPHYSIOLOGICAL ROLES OF PEROXYNITRITE IN CIRCULATORY SHOCK
Csaba Szabó, Katalin Módis · 2010 · Shock
Function of poly(ADP-ribose) polymerase in response to DNA damage: Gene-disruption study in mice
Mitsuko Masutani, Tadashige Nozaki, Eiko Nishiyama, Takashi Shimokawa, Yumiko Tachi, Hiroshi I. Suzuki, Hitoshi Nakagama, Keiji Wakabayashi, Takashi Sügimura · 1999 · Springer eBooks
Pharmacologic Inhibition of Poly(ADP-Ribose) Polymerase Is Neuroprotective Following Traumatic Brain Injury in Rats
Michelle C. LaPlaca, Jie Zhang, Ramesh Raghupathi, Jiahe Li, Fraser McLean Smith, Florence M. Bareyre, Solomon H. Snyder, David Ian Graham, Tracy K. McIntosh · 2001 · Journal of Neurotrauma
Apoptosis Inducing Factor and PARP‐Mediated Injury in the MPTP Mouse Model of Parkinson's Disease
Hongmin Wang, Mika Shimoji, Seong-Woon Yu, Ted M. Dawson, Valina Lynn Dawson · 2003 · Annals of the New York Academy of Sciences
Decrease of the inflammatory response and induction of the Akt/protein kinase B pathway by poly-(ADP-ribose) polymerase 1 inhibitor in endotoxin-induced septic shock
Balázs Veres, Ferenc Gallyas, Gábor Várbiró, Zoltán Berente, Erzsébet Ősz, Gyorgy Szekeres, Csaba Szabó, Balázs Sümegi · 2003 · Biochemical Pharmacology
Poly(ADP-ribose) polymerase-1 gene ablation protects mice from ischemic renal injury
Jianfeng Zheng, Kishor B. Devalaraja-Narashimha, Kurinji Singaravelu, Babu J. Padanilam · 2004 · American Journal of Physiology-Renal Physiology
A phase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours
Omar Khan, Martin Eric Gore, Paul C. Lorigan, J Stone, Alastair Greystoke, Wendy Burke, J Carmichael, Amanda J. Watson, Gail McGown, Mary R. Thorncroft et al. · 2011 · British Journal of Cancer
3-aminobenzamide and/or O6-benzylguanine evaluated as an adjuvant to temozolomide or BCNU treatment in cell lines of variable mismatch repair status and O6-alkylguanine-DNA alkyltransferase activity
Stephen R. Wedge, Julia K. Porteous, Edward S. Newlands · 1996 · British Journal of Cancer
Gene Knockout or Pharmacological Inhibition of Poly(ADP-Ribose) Polymerase-1 Prevents Lung Inflammation in a Murine Model of Asthma
A. Hamid Boulares, Anna J. Zoltoski, Zaki A. Sherif, Puneet S. Jolly, Donald J. Massaro, Mark E. Smulson · 2003 · American Journal of Respiratory Cell and Molecular Biology
Poly(ADP‐ribose) polymerase: Early involvement in glutamate‐induced neurotoxicity in cultured cerebellar granule cells
Cristina Cosi, Hisanori Suzuki, Daria Milani, Laura Facci, Marta Menegazzi, Guido Vantini, Y. Kanai, Stephen D. Skaper · 1994 · Journal of Neuroscience Research
Neuronal caspase-3 and PARP-1 correlate differentially with apoptosis and necrosis in ischemic human stroke
Tiina Sairanen, Rita Szepesi, Marja‐Liisa Karjalainen‐Lindsberg, Jani Saksi, Anders E. Paetau, Perttu J. Lindsberg · 2009 · Acta Neuropathologica
Role of peroxynitrite and neuronal nitric oxide synthase in the activation of poly(ADP-ribose) synthetase in a murine model of cerebral ischemia-reperfusion
Matthias Endres, Gwen S. Scott, Shobu Namura, Andrew L. Salzman, Paul Lee Huang, Michael A. Moskowitz, Csaba Szabó · 1998 · Neuroscience Letters
Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor Veliparib (ABT-888) in Combination with Irinotecan in Patients with Advanced Solid Tumors
Patricia Mucci LoRusso, Jing Li, Angelika M. Burger, Lance K. Heilbrun, Edward A. Sausville, Scott Anthony Boerner, Daryn W. Smith, Mary Jo Pilat, Jie Zhang, Sara M. Tolaney et al. · 2016 · Clinical Cancer Research
Dihydroisoquinolinones: the design and synthesis of a new series of potent inhibitors of poly(ADP-ribose) polymerase.
Mark J. Suto, William R. Turner, Carla M. Arundel-Suto, Leslie M. Werbel, Judith S. Sebolt · 1991 · PubMed
Regulation of the Expression of the Inducible Isoform of Nitric Oxide Synthase
Csaba Szabó, Christoph Thiemermann · 1995 · Advances in pharmacology
Use of a Poly(ADP-Ribose) Polymerase Inhibitor to Suppress Inflammation and Neuronal Death After Cerebral Ischemia-Reperfusion
Aaron M. Hamby, Sang Won Suh, Tiina M. Kauppinen, Raymond A. Swanson · 2007 · Stroke
Inhibition of poly(ADP-ribose) polymerase attenuates ischemic renal injury in rats
Daniel R. Martin, Andrew J P Lewington, Marc R. Hammerman, Babu J. Padanilam · 2000 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Identification of poly‐ADP‐ribosylated mitochondrial proteins after traumatic brain injury
Yichen Lai, Yaming Chen, Simon C. Watkins, Paula D. Nathaniel, Fengli Guo, Patrick Michael Kochanek, Larry W. Jenkins, Csaba Szabó, Robert S. B. Clark · 2007 · Journal of Neurochemistry
Poly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy
Jyothish B. Pillai, Madhu Gupta, Senthilkumar B. Rajamohan, Roberto Miguel Lang, Jai Raman, Mahesh P. Gupta · 2006 · American Journal of Physiology-Heart and Circulatory Physiology
Utility of DNA Repair Protein Foci for the Detection of Putative BRCA1 Pathway Defects in Breast Cancer Biopsies
Henning Willers, Alphonse G. Taghian, Chenmei Luo, Alejandro D. Treszezamsky, Dennis C. Sgroi, Simon N. Powell · 2009 · Molecular Cancer Research
Increased poly(ADP-ribosyl)ation in intact cells by cisplatin treatment
Alexander Bürkle, Guan Chen, Jan‐Heiner Küpper, Karlheinz Grube, Walter Jens Zeller · 1993 · Carcinogenesis
Gender Differences in Sepsis: Genetically Determined?
J.‐M. Schröder, Volker Kahlke, M Book, Frank Stüber · 2000 · Shock
Enhanced Killing of Cancer Cells by Poly(ADP-ribose) Polymerase Inhibitors and Topoisomerase I Inhibitors Reflects Poisoning of Both Enzymes
Anand G. Patel, Karen S. Flatten, Paula A. Schneider, Nga T. Dai, Jennifer S. McDonald, Guy G. Poirier, Scott H. Kaufmann · 2011 · Journal of Biological Chemistry
Inhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death
Veto, S., Acs, P., Bauer, J., Lassmann, H., Berente, Z., Setalo, G., Borgulya, G., Sumegi, B., Komoly, S., Gallyas, F. et al. · 2010 · Brain
Role of poly(ADP-ribose)synthetase in inflammation
Csaba Szabó · 1998 · European Journal of Pharmacology
Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development
1992 · Springer eBooks
Visualization of a DNA-PK/PARP1 complex
Laura Spagnolo, Jody Barbeau, Nicola J. Curtin, Edward P. Morris, Laurence H. Pearl · 2012 · Nucleic Acids Research
Gender Differences in the Endotoxin-Induced Inflammatory and Vascular Responses: Potential Role of Poly(ADP-ribose) Polymerase Activation
Jon G. Mabley, Eszter Maria Horvath, Kanneganti G. K. Murthy, Zsuzsanna K. Zsengellér, Anne Vaslin, Rita Benkő, Márk Kollai, Csaba Szabó · 2005 · Journal of Pharmacology and Experimental Therapeutics
Protective effect of a novel, potent inhibitor of poly(adenosine 5′-diphosphate-ribose) synthetase in a porcine model of severe bacterial sepsis*
Roy David Goldfarb, Anita Marton, Éva Szabó, László Virág, Andrew L. Salzman, Dana Glock, Imran Akhter, Robert J. McCarthy, Joseph E. Parrillo, Csaba Szabó · 2002 · Critical Care Medicine
Effect of poly(ADP ribose) synthetase inhibition on burn and smoke inhalation injury in sheep
Katsumi Shimoda, Kazunori Murakami, Perenlei Enkhbaatar, Lillian D. Traber, Robert A. Cox, Hal K. Hawkins, Frank C. Schmalstieg, Katalin Komjáti, Jon G. Mabley, Csaba Szabó et al. · 2003 · American Journal of Physiology-Lung Cellular and Molecular Physiology
Inhibition of poly(ADP‐ribose) polymerase prevents irinotecan‐induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma
Lucio Tentori, Carlo Leonetti, Marco Scarsella, Alessia Muzi, Emanuela Mazzon, Matteo Vergati, Olindo Forini, Rena G. Lapidus, Weizheng Xu, Annalisa Susanna Dorio et al. · 2006 · The FASEB Journal
Anti‐inflammatory effects of PJ34, a poly(ADP‐ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice
M Haddad, Hervé Rhinn, Carole Bloquel, Bérard Coqueran, Csaba Szabó, Michel Plotkine, Daniel Scherman, Isabelle Margaill · 2006 · British Journal of Pharmacology
Peroxynitrite Causes Energy Depletion and Increases Permeability via Activation of Poly (ADP-Ribose) Synthetase in Pulmonary Epithelial Cells
Csaba Szabó, C Saunders, Michael P O’Connor, Andrew L. Salzman · 1997 · American Journal of Respiratory Cell and Molecular Biology
A dual role for poly‐ADP‐ribosylation in spatial memory acquisition after traumatic brain injury in mice involving NAD+ depletion and ribosylation of 14‐3‐3γ
Margaret A. Satchell, Xiaopeng Zhang, Patrick Michael Kochanek, C. Edward Dixon, Larry W. Jenkins, John A. Melick, Csaba Szabó, Robert S. B. Clark · 2003 · Journal of Neurochemistry
First and final report of a phase II study of the poly(ADP-ribose) polymerase (PARP) inhibitor, AG014699, in combination with temozolomide (TMZ) in patients with metastatic malignant melanoma (MM)
Ruth Plummer, Paul C. Lorigan, J. Evans, Neil Matthew Steven, Mark Ross Middleton, R. Wilson, K. Snow, Raz Dewji, Hilary Calvert · 2006 · Journal of Clinical Oncology
Diabetes increases apoptosis and necrosis in both ischemic and nonischemic human myocardium: Role of caspases and poly–adenosine diphosphate–ribose polymerase
Mohammed Fiyaz Chowdhry, Hunaid Ahmed Vohra, Manuel Galiñanes · 2007 · Journal of Thoracic and Cardiovascular Surgery
BGP-15—a novel poly(ADP-ribose) polymerase inhibitor—protects against nephrotoxicity of cisplatin without compromising its antitumor activity
Ildikó Rácz, Kalman Tory, Ferenc Gallyas, Zoltán Berente, Erzsébet Ősz, Laszlo Jaszlits, Sandor Bernath, Balázs Sümegi, György Rabloczky, Peter Literati-Nagy · 2002 · Biochemical Pharmacology
Shock, inflammation and PARP
Salvatore Cuzzocrea · 2005 · Pharmacological Research
Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure
Pál Pacher, Lucas Liaudet, Jon G. Mabley, Katalin Komjáti, Csaba Szabó · 2002 · Journal of the American College of Cardiology
Effective sensitization of temozolomide by ABT-888 is lost with development of temozolomide resistance in glioblastoma xenograft lines
Michelle J. Clarke, Evan A. Mulligan, Patrick Thomas Grogan, Ann C. Mladek, Brett L. Carlson, Mark A. Schroeder, Nicola J. Curtin, Zhenkun Lou, Paul A. Decker, Wenting Wu et al. · 2009 · Molecular Cancer Therapeutics
Diabetes‐induced overexpression of endothelin‐1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP‐ribose) polymerase activation
О. H. Minchenko, Martin J. Stevens, Lauren White, Omorodola I. Abatan, Katalin Komjáti, Pal Pachter, Csaba Szabó, Irina G. Obrosova · 2003 · The FASEB Journal
Mechanisms of gender-linked ischemic brain injury
Mingyue Liu, Suzan Dziennis, Patricia D. Hurn, Nabil J. Alkayed · 2009 · Restorative Neurology and Neuroscience
Poly(ADP-ribose) polymerase-1 is a key mediator of cisplatin-induced kidney inflammation and injury
Partha Mukhopadhyay, Béla Horváth, Malek Kechrid, Galin Tanchian, Mohanraj Rajesh, Amarjit Singh Naura, A. Hamid Boulares, Pál Pacher · 2011 · Free Radical Biology and Medicine
Poly(ADP‐Ribose) Synthase Inhibition Reduces Ischemic Injury and Inflammation in Neonatal Rat Brain
Sarah Ducrocq, Nabila Benjelloun, Michel Plotkine, Yehezkel Ben‐Ari, Christiane Charriaut‐Marlangue · 2000 · Journal of Neurochemistry
Poly(ADP-ribose) synthetase activation mediates increased permeability induced by peroxynitrite in Caco-2BBe cells
Michelle Kennedy, Alvin G. Denenberg, Csaba Szabó, Andrew L. Salzman · 1998 · Gastroenterology
The effect of PARP inhibitor on ischaemic cell death, its related inflammation and survival signals
Seong‐Ho Koh, Younjoo Park, Chi Won Song, Jun Gyou Kim, Kisok Kim, Juhan Kim, Myung‐Ho Kim, Seung Ro Lee, Dong Won Kim, Hyun‐Jeung Yu et al. · 2004 · European Journal of Neuroscience
A novel in vivo post‐translational modification of p53 by PARP‐1 in MPTP‐induced parkinsonism
Allen S. Mandir, Cynthia Marie Simbulan-Rosenthal, Marc F. Poitras, John R. Lumpkin, Valina Lynn Dawson, Mark E. Smulson, Ted M. Dawson · 2002 · Journal of Neurochemistry
Early diabetes-induced biochemical changes in the retina: comparison of rat and mouse models
Obrosova, I. G., Drel, V. R., Kumagai, A. K., Szábo, C., Pacher, P., Stevens, M. J. · 2006 · Diabetologia
The potential for poly (ADP-ribose) polymerase inhibitors in cancer therapy
M.M. Javle, Nicola J. Curtin · 2011 · Therapeutic Advances in Medical Oncology
Effects of 5‐aminoisoquinolinone, a water‐soluble, potent inhibitor of the activity of poly (ADP‐ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock
Michelle C. McDonald, Hélder Mota‐Filipe, Jim Wright, Maha S. I. Abdelrahman, Michael D. Threadgill, Andrew S. Thompson, Christoph Thiemermann · 2000 · British Journal of Pharmacology
EFFECT OF GENETIC DISRUPTION OF POLY (ADP-RIBOSE) SYNTHETASE ON DELAYED PRODUCTION OF INFLAMMATORY MEDIATORS AND DELAYED NECROSIS DURING MYOCARDIAL ISCHEMIA-REPERFUSION INJURY
Zequan Yang, Basilia Zingarelli, Csaba Szabó · 2000 · Shock
A randomized, placebo-controlled trial to evaluate the tolerability, safety, pharmacokinetics, and pharmacodynamics of a potent inhibitor of poly(ADP-ribose) polymerase (INO-1001) in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: results of the TIMI 37 trial
David A. Morrow, Chaim M. Brickman, Sabina A. Murphy, Kenneth W. Baran, Ricardo Krakover, Harold L. Dauerman, Sujatha Kumar, Natanya Slomowitz, Laura T. Grip, Carolyn H. McCabe et al. · 2008 · Journal of Thrombosis and Thrombolysis
Temporal Patterns of Poly(ADP‐Ribose) Polymerase Activation in the Cortex Following Experimental Brain Injury in the Rat
Michelle C. LaPlaca, Ramesh Raghupathi, Ajay Mark Verma, Andrew A. Pieper, Kathryn E. Saatman, Solomon H. Snyder, Tracy K. McIntosh · 1999 · Journal of Neurochemistry
Function of poly(ADP-ribose) polymerase in response to DNA damage: Gene-disruption study in mice
Mitsuko Matsutani, Tadashige Nozaki, Eiko Nishiyama, Takashi Shimokawa, Yumiko Tachi, Hiroshi I. Suzuki, Hitoshi Nakagama, Keiji Wakabayashi, Takashi Sügimura · 1999 · Molecular and Cellular Biochemistry
Inhibitors of poly(ADP‐ribose) polymerase‐1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats
Alberto Chiarugi · 2002 · British Journal of Pharmacology
Poly(ADP-ribose) polymerase 1 activation is required for cisplatin nephrotoxicity
Jinu Kim, Kelly E. Long, Kang Lai Tang, Babu J. Padanilam · 2012 · Kidney International
Nitric oxide and shock
Robert G. Kilbourn, Daniel Lee Traber, Csaba Szabó · 1997 · Disease-a-Month
The role of PARP1 in the DNA damage response and its application in tumor therapy
Zhifeng Wang, Fengli Wang, Tie-Shan Tang, Caixia Guo · 2012 · Frontiers of Medicine
MK-4827, a PARP-1/-2 inhibitor, strongly enhances response of human lung and breast cancer xenografts to radiation
Li Wang, Kathy A. Mason, K. Kian Ang, Thomas A. Buchholz, David R. Valdecanas, Anjili Mathur, Carolyn Buser‐Doepner, Carlo Toniatti, Luka Milas · 2011 · Investigational New Drugs
PARP inhibitors: New tools to protect from inflammation
Vincenzo Giansanti, Francesca Donà, Micol Tillhon, Anna Ivana Scovassi · 2010 · Biochemical Pharmacology
Effect of L ‐buthionine‐(S,R)‐sulphoximine, an inhibitor of γ‐glutamylcysteine synthetase on peroxynitrite‐ and endotoxic shock‐induced vascular failure
Salvatore Cuzzocrea, Basilia Zingarelli, Michael O'Connor, Andrew L. Salzman, Csaba Szabó · 1998 · British Journal of Pharmacology
POLY (ADP-RIBOSE) SYNTHETASE MEDIATES INTESTINAL MUCOSAL BARRIER DYSFUNCTION AFTER MESENTERIC ISCHEMIA
Lucas Liaudet, Andrea Szabó, Francisco García Soriano, Basilia Zingarelli, Csaba Szabó, Andrew L. Salzman · 2000 · Shock
Sensitivity and Acquired Resistance of BRCA1;p53-Deficient Mouse Mammary Tumors to the Topoisomerase I Inhibitor Topotecan
Serge A.L. Zander, Ariena J. Kersbergen, Eline van der Burg, Niels de Water, Olaf van Tellingen, Sjöfn Gunnarsdottir, Janneke E. Jaspers, Marina Pajic, Anders O.H. Nygren, Jos Jonkers et al. · 2010 · Cancer Research
Inhibition of Poly(ADP-Ribose) Polymerase Suppresses Inflammation and Promotes Recovery after Ischemic Injury
Tiina M. Kauppinen, Sang Won Suh, Ari Berman, Aaron M. Hamby, Raymond A. Swanson · 2009 · Journal of Cerebral Blood Flow & Metabolism
Low-Dose Poly(ADP-Ribose) Polymerase Inhibitor-Containing Combination Therapies Reverse Early Peripheral Diabetic Neuropathy
Fei Li, Viktor R. Drel, Csaba Szabó, Martin J. Stevens, Irina G. Obrosova · 2005 · Diabetes
Inhibition of Poly(ADP-Ribose) Polymerase-1 Enhances Temozolomide and Topotecan Activity against Childhood Neuroblastoma
Rachel A. Daniel, Agata L. Rozanska, Huw D. Thomas, Evan A. Mulligan, Yvette Drew, Deborah J. Castelbuono, Zdeněk Hostomský, Elizabeth Ruth Plummer, Alan V. Boddy, Deborah A. Tweddle et al. · 2009 · Clinical Cancer Research
Suppression of poly (ADP‐ribose) polymerase activation by 3‐aminobenzamide in a rat model of myocardial infarction: long‐term morphological and functional consequences
Lucas Liaudet, Éva Szabó, Leonid Timashpolsky, László Virág, Attila Cziráki, Csaba Szabó · 2001 · British Journal of Pharmacology
Transcriptional regulation of human inducible nitric oxide synthase gene in an intestinal epithelial cell line
Stephen C. Linn, Peter J. Morelli, Iris Edry, Sarah Cottongim, Csaba Szabó, Andrew L. Salzman · 1997 · American Journal of Physiology-Gastrointestinal and Liver Physiology
Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site
Lucio Tentori, Carlo Leonetti, Marco Scarsella, Giulia d’Amati, Ilaria Portarena, Gabriella Zupi, Enzo Bonmassar, Grazia Graziani · 2002 · Blood
A Novel and Potent Poly(ADP-Ribose) Polymerase-1 Inhibitor, FR247304 (5-Chloro-2-[3-(4-phenyl-3,6-dihydro-1(2 H)-pyridinyl)propyl]-4(3 H)-quinazolinone), Attenuates Neuronal Damage in in Vitro and in Vivo Models of Cerebral Ischemia
Akinori Iwashita, Nobuteru Tojo, Shigeru Matsuura, Syunji Yamazaki, Kazunori Kamijo, Junya Ishida, Hirofumi Yamamoto, Kouji Hattori, Nobuya Matsuoka, Seitaro Mutoh · 2004 · Journal of Pharmacology and Experimental Therapeutics
Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes
Terry J. Gaymes, Sydney Shall, Lawrence J. MacPherson, Natalie A. Twine, N C Lea, Farzin Farzaneh, Ghulam Jeelani Mufti · 2009 · Haematologica
Proinflammatory cytokines depress cardiac efficiency by a nitric oxide-dependent mechanism
Donna L. Panas, Fadi Khadour, Csaba Szabó, Richard Schulz · 1998 · American Journal of Physiology-Heart and Circulatory Physiology
Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O 6-methylguanine-DNA methyltransferase activity
Terzah M. Horton, Gaye N. Jenkins, Debananda Pati, Linna Zhang, M. Eileen Dolan, Albert Ribes‐Zamora, Alison A. Bertuch, Susan M. Blaney, Shannon L. Delaney, Madhuri Hegde et al. · 2009 · Molecular Cancer Therapeutics
A New, Potent Poly(ADP-ribose) Polymerase Inhibitor Improves Cardiac and Vascular Dysfunction Associated with Advanced Aging
Pál Pacher, Anne Vaslin, Rita Benkő, Jon G. Mabley, Lucas Liaudet, György Haskó, Anita Marton, Sándor Bátkai, Márk Kollai, Csaba Szabó · 2004 · Journal of Pharmacology and Experimental Therapeutics
Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulus
Miguel Ángel Burguillos, Nabil Hajji, Elisabet M. Englund, A. Persson, Maria Angela Cenci, A. Machado, J. Cano, Bertrand Joseph, Jose Luis Venero · 2010 · Neurobiology of Disease
Discovery of Potent Poly(ADP-ribose) Polymerase-1 Inhibitors from the Modification of Indeno[1,2-c]isoquinolinone
Prakash G. Jagtap, Erkan Baloglu, Garry J. Southan, Jon G. Mabley, Hongshan Li, Jing Zhou, John van Duzer, Andrew L. Salzman, Csaba Szabó · 2005 · Journal of Medicinal Chemistry
Increased PARP-1 Association with DNA in Alkylation Damaged, PARP-Inhibited Mouse Fibroblasts
Padmini S. Kedar, Donna F. Stefanick, Julie K. Horton, Samuel H. Wilson · 2012 · Molecular Cancer Research
Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform
Garry J. Southan, Basilia Zingarelli, Michael O'Connor, Andrew L. Salzman, Csaba Szabó · 1996 · British Journal of Pharmacology
Response of Human Prostate Cancer Cells and Tumors to Combining PARP Inhibition with Ionizing Radiation
Juan Camilo Barreto-Andrade, Elena V. Efimova, Helena J. Mauceri, Michael A. Beckett, Harold G. Sutton, Thomas E. Darga, Everett E. Vokes, Mitchell C. Posner, Stephen J. Kron, Ralph R. Weichselbaum · 2011 · Molecular Cancer Therapeutics
Cellular bioenergetics is regulated by PARP1 under resting conditions and during oxidative stress
Katalin Módis, Domokos Gerő, Katalin Erdélyi, Petra Szoleczky, Douglas S. DeWitt, Csaba Szabó · 2011 · Biochemical Pharmacology
Mitochondrial-to-nuclear translocation of apoptosis-inducing factor in cardiac myocytes during oxidant stress: potential role of poly(ADP-ribose) polymerase-1
Min Chen · 2004 · Cardiovascular Research
Genetic variants of the ADPRT, XRCC1 and APE1 genes and risk of cutaneous melanoma
Chunying Li · 2006 · Carcinogenesis
Nifedipine inhibits the induction of nitric oxide synthase by bacterial lipopolysaccharide.
Csaba Szabó, Jane A. Mitchell, Steven S. Gross, Christoph Thiemermann, John Robert Vane · 1993 · Journal of Pharmacology and Experimental Therapeutics
Beneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure
Pál Pacher, Lucas Liaudet, Jon G. Mabley, Attila Cziráki, György Haskó, Csaba Szabó · 2006 · International Journal of Molecular Medicine
Sex Differences in the Response to Poly(ADP-ribose) Polymerase-1 Deletion and Caspase Inhibition After Stroke
Fudong Liu, Jesse T. Lang, Jun Li, Sharon E. Benashski, Matthew Siegel, Yan Xu, Louise D. McCullough · 2011 · Stroke
Evaluation of orally active poly(ADP-ribose) polymerase inhibitor in streptozotocin-diabetic rat model of early peripheral neuropathy
Omorodola I. Abatan, T. Charniauskaya, MJ Stevens, Irina G. Obrosova, Pál Pacher, F. Li, Csaba Szab�, Garry J. Southan · 2004 · Diabetologia
Defective homologous recombination in human cancers
Aiste Cerbinskaite, Asima Mukhopadhyay, Elizabeth Ruth Plummer, Nicola J. Curtin, Richard John Edmondson · 2011 · Cancer Treatment Reviews
Radiation induced DNA DSBs: Contribution from stalled replication forks?
Harper, Jane V., Anderson, Jennifer A., O’Neill, Peter · 2010 · DNA Repair
Deleterious poly(ADP-ribose)polymerase-1 pathway activation in traumatic brain injury in rat
Valérie C. Besson, Nicole Croci, Roger G Boulu, Michel Plotkine, Catherine Marchand‐Leroux · 2003 · Brain Research
The Therapeutic Effects of PJ34 [N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide.HCl], a Selective Inhibitor of Poly(ADP-Ribose) Polymerase, in Experimental Allergic Encephalomyelitis Are Associated with Immunomodulation
Gwen S. Scott, Rhonda B. Kean, Tatiana Mikheeva, Marzena J. Fabis, Jon G. Mabley, Csaba Szabó, Douglas Craig Hooper · 2004 · Journal of Pharmacology and Experimental Therapeutics
Identification of potent nontoxic poly(ADP-ribose) polymerase-1 inhibitors: Chemopotentiation and pharmacological studies
Christopher R. Calabrese, Michael A. Batey, Huw D. Thomas, Barbara W. Durkacz, Lan-Zhen Wang, Suzanne Kyle, Donald J. Skalitzky, Janke Li, Catherine R. Zhang, Theodore J. Boritzki et al. · 2003 · PubMed
ADP-ribosylation, DNA Repair, Cell Differentiation and Cancer
Sydney Shall · 2020 · CRC Press eBooks
Protection by Inhibition of Poly (ADP-ribose) Synthetase Against Oxidant Injury in Cardiac MyoblastsIn Vitro
Eli Gilad, Basilia Zingarelli, Andrew L. Salzman, Csaba Szabó · 1997 · Journal of Molecular and Cellular Cardiology
Head and neck cancer radiosensitization by the novel poly(ADP‐ribose) polymerase inhibitor GPI‐15427
Khurram Khan, Koji Araki, Daiyou Wang, Guayan Li, Xin Li, Jie Zhang, Weizheng Xu, Randall K. Hoover, Susan Lauter, Bert O'Malley et al. · 2009 · Head & Neck
4-Amino-1,8-naphthalimide: a novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer
Alexandra Schlicker · 1999 · International Journal of Radiation Biology
Potentiation of Temozolomide Cytotoxicity by Poly(ADP)Ribose Polymerase Inhibitor ABT-888 Requires a Conversion of Single-Stranded DNA Damages to Double-Stranded DNA Breaks
Xuesong Liu, Yan Shi, Ran Guan, Cherrie K. Donawho, Yanping Luo, Joann P. Palma, Gui‐Dong Zhu, Eric Feral Johnson, Luis Eduardo Rodriguez, Nayereh S Ghoreishi-Haack et al. · 2008 · Molecular Cancer Research
Inhibition of Poly (ADP-ribose) Polymerase Attenuates Acute Lung Injury in an Ovine Model of Sepsis
Kazunori Murakami, Perenlei Enkhbaatar, Katsumi Shimoda, Robert A. Cox, Ann S. Burke, Hal K. Hawkins, Lillian D. Traber, Frank C. Schmalstieg, Andrew L. Salzman, Jon G. Mabley et al. · 2004 · Shock
The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1)
Prakash G. Jagtap, Garry J. Southan, Erkan Baloglu, Siya Ram, Jon G. Mabley, Anita Marton, Andrew L. Salzman, Csaba Szabó · 2003 · Bioorganic & Medicinal Chemistry Letters
Neuronal accumulation of poly(ADP‐ribose) after brain ischaemia
Seth Love, Barber, Wilcock · 1999 · Neuropathology and Applied Neurobiology
Imidazoquinolinone, Imidazopyridine, and Isoquinolindione Derivatives as Novel and Potent Inhibitors of the Poly(ADP-ribose) Polymerase (PARP): A Comparison with Standard PARP Inhibitors
Tobias Eltze, Rainer Boer, Thomas Wagner, Steffen Weinbrenner, Michelle C. McDonald, Christoph Thiemermann, Alexander Bürkle, Thomas Klein · 2008 · Molecular Pharmacology
Poly(ADP-ribose) polymerase activation in the reperfused myocardium
Gabor B. Szabo · 2004 · Cardiovascular Research
Inhibitors of Poly(ADP-Ribose) Polymerase Modulate Signal Transduction Pathways and Secondary Damage in Experimental Spinal Cord Trauma
Tiziana Genovese, Emanuela Mazzon, Carmelo Muià, Nimesh S. A. Patel, Michael D. Threadgill, Placido Bramanti, Angelina De Sarro, Christoph Thiemermann, Salvatore Cuzzocrea · 2005 · Journal of Pharmacology and Experimental Therapeutics
Association of DNA Repair Gene Polymorphisms With Response to Platinum-Based Doublet Chemotherapy in Patients With Non–Small-Cell Lung Cancer
Kouya Shiraishi, Takashi Kohno, Chiharu Tanai, Yasushi Goto, Aya Kuchiba, Seiichiro Yamamoto, Koji Tsuta, Hiroshi Nokihara, Noboru Yamamoto, Ikuo Sekine et al. · 2010 · Journal of Clinical Oncology
Matrix metalloproteinase activation is an early event in doxorubicin-induced cardiotoxicity
Péter Bai, Jon G. Mabley, Lucas Liaudet, László Virág, Csaba Szabó, Pál Pacher · 2004 · Oncology Reports
Systemic poly(ADP-ribose) polymerase-1 activation, chronic inflammation, and oxidative stress in COPD patients
Geja J. Hageman · 2003 · Free Radical Biology and Medicine
Oxidative DNA damage and augmentation of poly(ADP-ribose) polymerase/nuclear factor-kappa B signaling in patients with Type 2 diabetes and microangiopathy
Antonysunil Adaikalakoteswari, Mohan Rema, Viswanathan Mohan, Muthuswamy Balasubramanyam · 2007 · The International Journal of Biochemistry & Cell Biology
The expression of PARP, NF-κB and parvalbumin is increased in Parkinson disease
Judit Soós, József I. Engelhardt, László Siklós, László Havas, Katalin Majtényi · 2004 · Neuroreport
Poly(ADP-ribose) polymerase-1 polymorphisms, expression and activity in selected human tumour cell lines
Tomasz Zaremba, Patrick Ketzer, Michael F Cole, Sally A. Coulthard, Elizabeth Ruth Plummer, Nicola J. Curtin · 2009 · British Journal of Cancer
Contribution of Poly(ADP-Ribose) Polymerase to Postischemic Blood—Brain Barrier Damage in Rats
Gábor Lenzsér, Béla Kis, James Andy Snipes, Tamás Gáspár, Péter Sándor, Katalin Komjáti, Csaba Szabó, David W. Busija · 2007 · Journal of Cerebral Blood Flow & Metabolism
Poly(ADP-ribose) polymerase-1 (PARP-1) pharmacogenetics, activity and expression analysis in cancer patients and healthy volunteers
Tomasz Zaremba, Huw D. Thomas, Michael F Cole, Sally A. Coulthard, Elizabeth Ruth Plummer, Nicola J. Curtin · 2011 · Biochemical Journal
Poly(ADP-ribose) polymerase inhibition protect neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke
Katalin Komjáti, John Mabley, László Virág, Garry J. Southan, Andrew L. Salzman, Csaba Szabó · 2004 · International Journal of Molecular Medicine
Inhibitors of the activity of poly (ADP‐ribose) synthetase reduce the cell death caused by hydrogen peroxide in human cardiac myoblasts
Joanne Bowes, Julie Piper, Christoph Thiemermann · 1998 · British Journal of Pharmacology
Inhibition of poly(ADP-ribose) polymerase attenuates the severity of acute pancreatitis and associated lung injury
Rubén Mota, Francisco Sanchez Bueno, Luis Saenz, David Hernández‐Espinosa, Jaime Jimeno, Pedro Luis Tornel, Alejandro Martínez-Torrano, Pablo Ramı́rez, Pascual Parrilla, José Yélamos · 2005 · Laboratory Investigation
Novel modulators of poly(ADP-ribose) polymerase
Csaba Szabó, Pál Pacher, Raymond A. Swanson · 2006 · Trends in Pharmacological Sciences
Implication of Poly(ADP‐Ribose) Polymerase (PARP) in Neurodegeneration and Brain Energy Metabolism: Decreases in Mouse Brain NAD+ and ATP Caused by MPTP Are Prevented by the PARP Inhibitor Benzamide
Cristina Cosi, Marc R. Marien · 1999 · Annals of the New York Academy of Sciences
Overweight worsens apoptosis, neuroinflammation and blood-brain barrier damage after hypoxic ischemia in neonatal brain through JNK hyperactivation
Yi‐Fang Tu, Yau-Sheng Tsai, Lan‐Wan Wang, Hsin‐Chieh Wu, Chao Huang, Chien-Jung Ho · 2011 · Journal of Neuroinflammation
Poly(ADP-ribose) polymerase-1 mRNA expression in human breast cancer: a meta-analysis
Anthony Gonçalvès, Pascal Finetti, Renaud Sabatier, Marine Gilabert, José Adélaı̈de, Jean‐Paul Borg, Max Chaffanet, Patrice Viens, Daniel Birnbaum, François Bertucci · 2010 · Breast Cancer Research and Treatment
Radiosensitization of human and rodent cell lines by INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase
William A. Brock, Luka Milas, Sherry Bergh, Ruth Lo, Csaba Szabó, Kathy A. Mason · 2004 · Cancer Letters
Myocardial protection by PJ34, a novel potent poly (ADP-ribose) synthetase inhibitor
Renato Faro, Yoshiya Toyoda, James D. McCully, Prakash G. Jagtap, Éva Szabó, László Virág, Cesario F. Bianchi, Sidney Levitsky, Csaba Szabó, Frank William Sellke · 2002 · The Annals of Thoracic Surgery
A Phase IB Trial of Intravenous INO-1001 Plus Oral Temozolomide in Subjects with Unresectable Stage-III or IV Melanoma
Agop Y. Bedikian, Nicholas E. Papadopoulos, Kevin B. Kim, Wen‐Jen Hwu, Jade Homsi, Michelle R. Glass, Suzanne Cain, Patrick J. Rudewicz, Laurent Vernillet, Patrick Hwu · 2009 · Cancer Investigation
Neuroprotective Effects of a Novel Poly(ADP-Ribose) Polymerase-1 Inhibitor, 2-{3-[4-(4-Chlorophenyl)-1-piperazinyl] propyl}-4(3 H)-quinazolinone (FR255595), in an in Vitro Model of Cell Death and in Mouse 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Model of Parkinson’s Disease
Akinori Iwashita, Syunji Yamazaki, Kayoko Mihara, Kouji Hattori, Hirofumi Yamamoto, Junya Ishida, Nobuya Matsuoka, Seitaro Mutoh · 2004 · Journal of Pharmacology and Experimental Therapeutics
Carotid ligation in gerbils. Influence of age, sex, and gonads.
HUSHANG M. PAYAN, Jaqueline Conrad · 1977 · Stroke
PARP inhibition delays transition of hypertensive cardiopathy to heart failure in spontaneously hypertensive rats
Éva Bartha, I. Solti, László Kereskai, János Lantos, Enikő Plózer, Klara Magyar, Eszter Szabados, Tamás Kálai, Kálmán Hideg, Róbert Halmosi et al. · 2009 · Cardiovascular Research
Importance of cell proliferative state and potentially lethal damage repair on radiation effectiveness: Implications for combined tumor treatments (Review)
G.W. Barendsen, Chris van BREE, Nicolaas A.P. Franken · 2001 · International Journal of Oncology
Increased expression of poly(ADP-ribose) polymerase-1 contributes to caspase-independent myocyte cell death during heart failure
Jyothish B. Pillai, Hyde M. Russell, Jai Raman, Valluvan Jeevanandam, Mahesh P. Gupta · 2004 · American Journal of Physiology-Heart and Circulatory Physiology
Poly(ADP-Ribose)Polymerase Inhibition Counteracts Cataract Formation and Early Retinal Changes in Streptozotocin-Diabetic Rats
Viktor R. Drel, Weizheng Xu, Jie Zhang, Peter F. Kador, Tayyeba K. Ali, Jeho Shin, Ulrich Julius, Barbara Stauch Slusher, Azza B. El‐Remessy, Irina G. Obrosova · 2009 · Investigative Ophthalmology & Visual Science
Olaparib plus paclitaxel plus carboplatin (P/C) followed by olaparib maintenance treatment in patients (pts) with platinum-sensitive recurrent serous ovarian cancer (PSR SOC): A randomized, open-label phase II study.
Amit M. Oza, David Cibula, Ana Oaknin, Christopher John Poole, Ron H.J. Mathijssen, Gabe S. Sonke, Nicoletta Colombo, Jiří Špaček, Peter Vuylsteke, Hal W. Hirte et al. · 2012 · Journal of Clinical Oncology
Genomic instability in breast and ovarian cancers: translation into clinical predictive biomarkers
Marieke A. Vollebergh, Jos Jonkers, Sabine C. Linn · 2011 · Cellular and Molecular Life Sciences
Poly(ADP-ribose) polymerase-1 hyperactivation and impairment of mitochondrial respiratory chain complex I function in reperfused mouse hearts
Hui-Zhong Zhou, Raymond A. Swanson, Ursula Simonis, Xiaokui Ma, Gary Cecchini, Mary O. Gray · 2006 · American Journal of Physiology-Heart and Circulatory Physiology
Poly(ADP-ribose)polymerase Inhibition - Where Now?
Esther C. Y. Woon, Michael D. Threadgill · 2005 · Current Medicinal Chemistry
POTENTIAL ROLE OF THE PEROXYNITRITE-POLY(ADP-RIBOSE) SYNTHETASE PATHWAY IN A RAT MODEL OF SEVERE HEMORRHAGIC SHOCK
Csaba Szabó · 1998 · Shock
Inhibitors of poly(adenosine diphosphoribose) synthetase, examination of metabolic perturbations, and enhancement of radiation response in Chinese hamster cells.
Ehud Ben‐Hur, Chia‐Chieh Chen, M. M. Elkind · 1985 · PubMed
Traumatic neuroprotection with inhibitors of nitric oxide and ADP-ribosylation
Roi Ann Wallis, Kimberly L. Panizzon, Joanna M. Girard · 1996 · Brain Research
Poly(ADP-ribose) polymerase regulates myocardial calcium handling in doxorubicin-induced heart failure
Orsolya Szenczi, Péter Kemecsei, Max F.J. Holthuijsen, Natal A. W. van Riel, Ger J. Vusse, Pál Pacher, Csaba Szabó, Márk Kollai, L. Ligeti, Tamás Ivanics · 2005 · Biochemical Pharmacology
Poly(ADP-Ribose) Polymerase Contributes to the Development of Myocardial Infarction in Diabetic Rats and Regulates the Nuclear Translocation of Apoptosis-Inducing Factor
Chun-Yang Xiao, Min Chen, Zsuzsanna K. Zsengellér, Csaba Szabó · 2004 · Journal of Pharmacology and Experimental Therapeutics
Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation
Ravinder Kumar Kaundal, Kaushik K. Shah, Shyam Sundar Sharma · 2006 · Life Sciences
Inhibition of the activity of poly (ADP‐ribose) polymerase reduces heart ischaemia/reperfusion injury via suppressing JNK‐mediated AIF translocation
Zhaofeng Song, Xiaoping Ji, Xiaoxing Li, Shengjun Wang, Shuhua Wang, Yun‐Zhang · 2008 · Journal of Cellular and Molecular Medicine
An inhibitor of poly (ADP‐ribose) synthetase activity reduces contractile dysfunction and preserves high energy phosphate levels during reperfusion of the ischaemic rat heart
John C. Docherty, Bozena Kuzio, Jocelyn Anne Silvester, Joanne Bowes, Christoph Thiemermann · 1999 · British Journal of Pharmacology
PROTECTIVE EFFECTS OF NICOTINAMIDE AGAINST NITRIC OXIDE-MEDIATED DELAYED VASCULAR FAILURE IN ENDOTOXIC SHOCK
Basilia Zingarelli, Andrew L. Salzman, Csaba Szabó · 1996 · Shock
Poly(ADP-ribose) Polymerase is a Regulator of Chemokine Production: Relevance for the Pathogenesis of Shock and Inflammation
György Haskó, Jon G. Mabley, Zoltan H. Nemeth, Pál Pacher, Edwin A. Deitch, Csaba Szabó · 2002 · Molecular Medicine
Effects of poly(ADP-ribose) polymerase inhibition on inflammatory cell migration in a murine model of asthma.
László Virág, Péter Bai, István Bak, Pál Pacher, Jon G. Mabley, Lucas Liaudet, Edina Bakondi, Pál Gergely, Márk Kollai, Csaba Szabó · 2004 · PubMed
Poly(ADP-ribose) polymerase-2 depletion reduces doxorubicin-induced damage through SIRT1 induction
Magdolna Szántó, Ibolya Rutkai, Csaba Hegedűs, Ágnes Czikora, Máté Rózsahegyi, Borbála Kiss, László Virág, Pál Gergely, Attila Tóth, Péter Bai · 2011 · Cardiovascular Research
Hydrogen sulfide protects SH-SY5Y cells against 6-hydroxydopamine-induced endoplasmic reticulum stress
Li Huitong Xie, Chi Xin Tiong, Jin‐Song Bian · 2012 · American Journal of Physiology-Cell Physiology
Poly-ADP-ribosylation in health and disease
David W. Koh, Ted M. Dawson, Valina Lynn Dawson · 2005 · Cellular and Molecular Life Sciences
Novel potent inhibitors of the DNA-repair enzyme poly (ADP-ribose)polymerase (PARP)
Roger J. Griffin, LC Pemberton, Daniela Rhodes, Christine Bleasdale, Karen J. Bowman, Hilary Calvert, Nicola J. Curtin, Barbara W. Durkacz, Newell Dr, Julia K. Porteous et al. · 1995 · PubMed
Phase II randomized placebo-controlled study of olaparib (AZD2281) in patients with platinum-sensitive relapsed serous ovarian cancer (PSR SOC).
Jonathan Andrew Ledermann, Philipp Harter, Charles Gourley, Michael Leonard Friedlander, Ignace B. Vergote, Gordon J.S. Rustin, C. Scott, Werner Meier, Ronnie Shapira‐Frommer, Tamar Safra et al. · 2011 · Journal of Clinical Oncology
Role for Poly(ADP-ribose) Polymerase Activation in Diabetic Nephropathy, Neuropathy and Retinopathy
Irina G. Obrosova, Ulrich Julius · 2005 · Current Vascular Pharmacology
Protection against Hypoxia-reoxygenation in the Absence of Poly (ADP-ribose) Synthetase in Isolated Working Hearts
Ingrid L. Grupp, Traci M. Jackson, Paul W. Hake, Gunther Grupp, Csaba Szabó · 1999 · Journal of Molecular and Cellular Cardiology
Poly (ADP-Ribose) Polymerase Inhibitors as Potential Therapeutic Agents in Stroke and Neurotrauma
Katalin Komjáti, Valérie C. Besson, Csaba Szabó · 2005 · CNS & Neurological Disorders - Drug Targets
Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699
Rachel A. Daniel, Agata L. Rozanska, Evan A. Mulligan, Yvette Drew, Huw D. Thomas, Deborah J. Castelbuono, Zdeněk Hostomský, Elizabeth Ruth Plummer, Deborah A. Tweddle, Alan V. Boddy et al. · 2010 · British Journal of Cancer
First-in-human trial of a poly(ADP)-ribose polymerase (PARP) inhibitor MK-4827 in advanced cancer patients with antitumor activity in BRCA-deficient tumors and sporadic ovarian cancers (soc).
William R. Schelman, Shahneen Kaur Sandhu, V. Moreno Garcia, George Wilding, Long Sun, Carlo Toniatti, Mark Stroh, N. Kreischer, C. L. Carpenter, L. Rhoda Molife et al. · 2011 · Journal of Clinical Oncology
PARP Expression Is Increased in Astrocytes but Decreased in Motor Neurons in the Spinal Cord of Sporadic ALS Patients
Seung Hyun Kim, J. Henkel-Tigges, David R. Beers, İhsan Şükrü Şengün, Ericka P. Simpson, Jerry Clay Goodman, József I. Engelhardt, László Siklós, Stanley H. Appel · 2003 · Journal of Neuropathology & Experimental Neurology
Design and synthesis of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. part 4: Biological evaluation of imidazobenzodiazepines as potent PARP-1 inhibitors for treatment of ischemic injuries
Dana V. Ferraris, Rica Pargas Ficco, David Dain, Mark J. Ginski, Susan L. Lautar, Kathy Lee-Wisdom, Liang Shi, Qian Lin, May X.-C Lu, Lisa A. Morgan et al. · 2003 · Bioorganic & Medicinal Chemistry
Local Administration of the Poly(ADP-Ribose) Polymerase Inhibitor INO-1001 Prevents NAD + Depletion and Improves Water Maze Performance after Traumatic Brain Injury in Mice
Robert S. B. Clark, Vincent Vagni, Paula D. Nathaniel, Larry W. Jenkins, C. Edward Dixon, Csaba Szabó · 2007 · Journal of Neurotrauma
The Clinically Active PARP Inhibitor AG014699 Ameliorates Cardiotoxicity but Does Not Enhance the Efficacy of Doxorubicin, despite Improving Tumor Perfusion and Radiation Response in Mice
Majid Ali, Marzieh Kamjoo, Huw D. Thomas, Suzanne Kyle, Ivanda Pavlovska, Muhammed Babur, Brian A. Telfer, Nicola J. Curtin, Kaye Janine Williams · 2011 · Molecular Cancer Therapeutics
Long‐lasting neuroprotection and neurological improvement in stroke models with new, potent and brain permeable inhibitors of poly(ADP‐ribose) polymerase
Flavio Moroni, A Cozzi, Alberto Chiarugi, Laura Formentini, Emidio Camaioni, Domenico Edoardo Pellegrini-Giampietro, Yong Chen, S Liang, MM Zaleska, Cathleen Gonzales et al. · 2011 · British Journal of Pharmacology
A Newly Synthesized Poly(ADP-Ribose) Polymerase Inhibitor, DR2313 [2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: Pharmacological Profiles, Neuroprotective Effects, and Therapeutic Time Window in Cerebral Ischemia in Rats
Hidemitsu Nakajima, Nobukazu Kakui, Kunihiro Ohkuma, Midori Ishikawa, Toshifumi Hasegawa · 2005 · Journal of Pharmacology and Experimental Therapeutics
BGP-15, a PARP-inhibitor, prevents imatinib-induced cardiotoxicity by activating Akt and suppressing JNK and p38 MAP kinases
Zsolt Sárszegi, Eszter Bognar, Balázs Gaszner, Attila Kónyi, Ferenc Gallyas, Balázs Sümegi, Zoltán Berente · 2012 · Molecular and Cellular Biochemistry
Vasoactivity of AG014699, a Clinically Active Small Molecule Inhibitor of Poly(ADP-ribose) Polymerase: a Contributory Factor to Chemopotentiation In vivo ?
Majid Ali, Brian A. Telfer, Cian Michael McCrudden, Martin O’Rourke, Huw D. Thomas, Marzieh Kamjoo, Suzanne Kyle, Tracy Robson, Chris Shaw, David Graham Hirst et al. · 2009 · Clinical Cancer Research
Absence of Poly(ADP-ribose) Polymerase-1 Alters Nuclear Factor-κB Activation and Gene Expression of Apoptosis Regulators after Reperfusion Injury
Basilia Zingarelli, Paul W. Hake, Michael O’Connor, Alvin G. Denenberg, Sue Kong, Bruce J. Aronow · 2003 · Molecular Medicine
Evaluation of the poly(ADP‐ribose) polymerase‐1 gene variants in Alzheimer's disease
Hsin‐Ping Liu, Wei‐Yong Lin, Bor‐Tsang Wu, S. R. Liu, Wenfu Wang, Chon‐Haw Tsai, Chun‐Cheng Lee, Fuu‐Jen Tsai · 2010 · Journal of Clinical Laboratory Analysis
Poly(ADP-Ribose) Polymerase-1 and DNA-Dependent Protein Kinase Have Equivalent Roles in Double Strand Break Repair Following Ionizing Radiation
Jody Mitchell, Graeme C.M. Smith, Nicola J. Curtin · 2009 · International Journal of Radiation Oncology*Biology*Physics
Poly(ADP-ribose) polymerase-mediated cell injury in acute renal failure
Kishor B. Devalaraja-Narashimha, Kurinji Singaravelu, Babu J. Padanilam · 2005 · Pharmacological Research
Regulation of components of the inflammatory response by 5-iodo-6-amino-1,2-benzopyrone, an inhibitor of poly(ADP-ribose) synthetase and pleiotropic modifier of cellular signal pathways
Csaba Szabó, Hector R. Wong, P Bauer, E. Kirsten, Michael O’Connor, Basilia Zingarelli, Jerome Mendeleyev, György Haskó, E. Sylvester Vizi, Andrew L. Salzman et al. · 1997 · International Journal of Oncology
Treatment with temozolomide and poly(ADP-ribose) polymerase inhibitors induces early apoptosis and increases base excision repair gene transcripts in leukemic cells resistant to triazene compounds
Lucio Tentori, Mario Turriziani, Daniela Franco, Annalucia Serafino, Lauretta Levati, Rabindra Roy, Enzo Bonmassar, Grazia Graziani · 1999 · Leukemia
Prevention of Traumatic Brain Injury-Induced Neuron Death by Intranasal Delivery of Nicotinamide Adenine Dinucleotide
Seok Joon Won, Bo Young Choi, Byung Hoon Yoo, Min Sohn, Weihai Ying, Raymond A. Swanson, Sang Won Suh · 2012 · Journal of Neurotrauma
Protection Against Chronic Hypoperfusion-Induced Retinal Neurodegeneration by PARP Inhibition via Activation of PI-3-kinase Akt Pathway and Suppression of JNK and p38 MAP Kinases
Laszlo Mester, Alíz Szabó, Tamás Atlasz, Krisztina Szabadfi, Dóra Reglődi, P. Kiss, Bóglárka Rácz, Andrea Tamás, Ferenc Gallyas, Balázs Sümegi et al. · 2009 · Neurotoxicity Research
Emerging drugs for diabetic neuropathy
Abd A. Tahrani, Trevor Askwith, Martin J. Stevens · 2010 · Expert Opinion on Emerging Drugs
PARP-1 deficiency blocks IL-5 expression through calpain-dependent degradation of STAT-6 in a murine asthma model
R. Datta, Amarjit Singh Naura, Mourad Zerfaoui, Youssef Errami, Mustapha Oumouna, Hyeyoung Kim, Jihang Ju, Virginia Paola Ronchi, Arthur L. Haas, A. Hamid Boulares · 2011 · Allergy
Poly(ADP-Ribose) Polymerase During Reperfusion After Transient Forebrain Ischemia: Its Role in Brain Edema and Cell Death
Robert Piotr Strosznajder, Roman Gadamski, Grzegorz Arkadiusz Czapski, Henryk M. Jęśko, Joanna Benigna Strosznajder · 2003 · Journal of Molecular Neuroscience
Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis
G.S. Scott, Paul W. Hake, Rhonda B. Kean, László Virág, Csaba Szabó, Douglas Craig Hooper · 2001 · Journal of Neuroimmunology
EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseases
Isabelle Cousineau, Abdellah Belmaaza · 2011 · Molecular Genetics and Genomics
Poly(ADP‐ribose) polymerase‐1, a novel partner of progesterone receptors in endometrial cancer and its precursors
Lina Ghabreau, Jean Paul Roux, Pierre‐Olivier Frappart, Patrice Mathevet, Louis Marc Patricot, Moncef Mokni, Sadok Korbi, Zhao‐Qi Wang, Wei‐Min Tong, Lucien Frappart · 2004 · International Journal of Cancer
Poly(ADP-Ribose) Polymerase 1 Inhibition Improves Coronary Arteriole Function in Type 2 Diabetes Mellitus
Soo Kyoung Choi, María Galán, Modar Kassan, Megan Partyka, Mohamed Trebak, Khalid Matrougui · 2012 · Hypertension
Activation of the Poly(ADP-Ribose) Polymerase Pathway in Human Heart Failure
Andrea Molnár, Attila Tóth, Zsolt A Bagi, Zoltán Papp, Istvan Ferenc Edes, Miklós Vaszily, Zoltán Galajda, Julius Gy. Papp, András Varró, Viktória Szüts et al. · 2006 · Molecular Medicine
PARP inhibitors in breast cancer: BRCA and beyond.
Jorge A. Rios, Shannon Puhalla · 2011 · PubMed
NAD+ depletion or PAR polymer formation: which plays the role of executioner in ischaemic cell death?
C. Siegel, Louise D. McCullough · 2010 · Acta Physiologica
Role of poly(ADP-ribose) polymerase activation in endotoxin-induced cardiac collapse in rodents
Pál Pacher, Attila Cziráki, Jon G. Mabley, Lucas Liaudet, Lajos Papp, Csaba Szabó · 2002 · Biochemical Pharmacology
PARP-1 Val762Ala polymorphism, CagA+ H. pylori infection and risk for gastric cancer in Han Chinese population
Quanbao Zhang, Yumin Li, Xun� Li, Wence Zhou, Bin Shi, Hao Chen, Wenzhen Yuan · 2008 · Molecular Biology Reports
Activation of Poly(ADP-Ribose) Polymerase by Myocardial Ischemia and Coronary Reperfusion in Human Circulating Leukocytes
Emese Tóth-Zsámboki, Eszter Maria Horvath, Katarína Vargová, Eszter Pankotai, Kanneganti G. K. Murthy, Zsuzsanna K. Zsengellér, Tamás Bárány, Tamás Pék, Katalin Fekete, Róbert Gábor Kiss et al. · 2006 · Molecular Medicine
Glioma risk associates with polymorphisms of DNA repair genes, XRCC1 and PARP1
Elif Yosunkaya Fenerci, Barış Küçükyürük, İlhan Onaran, Cigdem Bayram Gurel, Mustafa Uzan, Gönül Kanıgür Sultuybek · 2010 · British Journal of Neurosurgery
Inhibition of Poly(ADP-Ribose) Polymerase Prevents Allergen-Induced Asthma-Like Reaction in Sensitized Guinea Pigs
Ylenia Suzuki, Emanuela Masini, Cosimo Mazzocca, Salvatore Cuzzocrea, Anna Rosa Ciampa, Hisanori Suzuki, Danièle Bani · 2004 · Journal of Pharmacology and Experimental Therapeutics
MP-124, a novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor, ameliorates ischemic brain damage in a non-human primate model
Shigeru Matsuura, Yasuhiro Egi, Satoshi Yuki, Takashi Horikawa, Hiroyuki Satoh, Toshiaki Akira · 2011 · Brain Research
Beneficial effects of PJ34 and INO-1001, two novel water-soluble poly(ADP-ribose) polymerase inhibitors, on the consequences of traumatic brain injury in rat
Valérie C. Besson, Zsuzsanna K. Zsengellér, Michel Plotkine, Csaba Szabó, Catherine Marchand‐Leroux · 2005 · Brain Research
Reduction of hemorrhagic transformation by PJ34, a poly(ADP-ribose)polymerase inhibitor, after permanent focal cerebral ischemia in mice
Marianne Haddad, Virginie Beray‐Berthat, Bérard Coqueran, Bruno Palmier, Csaba Szabó, Michel Plotkine, Isabelle Margaill · 2008 · European Journal of Pharmacology
Poly(ADP‐ribose) polymerase‐1 activation in a primate model of multiple sclerosis
Tiina M. Kauppinen, Sang Won Suh, Claude P. Genain, Raymond A. Swanson · 2005 · Journal of Neuroscience Research
Myocardial Ischemic Preconditioning in Rodents Is Dependent on Poly (ADP-Ribose) Synthetase
Lucas Liaudet, Zequan Yang, E.B. Affar, Csaba Szabó · 2001 · Molecular Medicine
PARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severity
Cavone, Leonardo, Aldinucci, Alessandra, Ballerini, Clara, Biagioli, Tiziana, Moroni, Flavio, Chiarugi, Alberto · 2011 · Multiple Sclerosis Journal
Effect of PD 128763, a new potent inhibitor of poly(ADP-ribose) polymerase, on X-ray-induced cellular recovery processes in Chinese hamster V79 cells.
Carla M. Arundel-Suto, Sylvia V. Scavone, William R. Turner, Mark J. Suto, Judith S. Sebolt · 1991 · PubMed
Tumor necrosis factor-like weak inducer of apoptosis and fibroblast growth factor-inducible 14 mediate cerebral ischemia-induced poly(ADP-ribose) polymerase-1 activation and neuronal death
Woldeab B. Haile, Ramiro Echeverry, F. Wu, J. Guzman, Jie An, Jialing Wu, Manuel Yepes · 2010 · Neuroscience
Protective effects of 5-iodo-6-amino-1,2-benzopyrone, an inhibitor of poly(ADP-ribose) synthetase against peroxynitrite-induced glial damage and stroke development
Matthias Endres, Gwen S. Scott, Andrew L. Salzman, Ernest Kun, Michael A. Moskowitz, Csaba Szabó · 1998 · European Journal of Pharmacology
Inhibition of poly(adenosine diphosphate-ribose) polymerase by the active form of vitamin D
Jon G. Mabley, Rebecca Wallace, Pál Pacher, Kanneganti Murphy, Csaba Szabó · 2007 · International Journal of Molecular Medicine
Indices of Apoptosis Activation After Blood Cardioplegia and Cardiopulmonary Bypass
Basel Ramlawi, Jun Feng, Shigetoshi Mieno, Csaba Szabó, Zsuzsanna K. Zsengellér, Richard Clements, Neel Raj Sodha, Munir Boodhwani, Cesario F. Bianchi, Frank William Sellke · 2006 · Circulation
Poly(ADP-ribose) polymerase-1 activity facilitates the dissociation of nuclear proteins from platinum-modified DNA
Evan R. Guggenheim, Alison E. Ondrus, Mohammad Movassaghi, Stephen J. Lippard · 2008 · Bioorganic & Medicinal Chemistry
Role of PARP on iNOS pathway during endotoxin-induced acute lung injury
Rainer Kiefmann, Kai Heckel, Martina Dörger, Sonja Schenkat, Christian Kupatt, Mechthild Stoeckelhuber, Józefa Węsierska‐Gądek, AlwinE. Goetz · 2004 · Intensive Care Medicine