Bile acids and their receptors
Abstract
Primary bile acids are synthetized from cholesterol within the liver and then transformed by the bacteria in the intestine to secondary bile acids. In addition to their involvement in digestion and fat solubilization, bile acids also act as signaling molecules. Several receptors are sensors of bile acids. Among these receptors, this review focuses on the nuclear receptor FXRα and the G-protein-coupled receptor TGR5. This review briefly presents the potential links between bile acids and cancers that are discussed in more details in the other articles of this special issue of Molecular Aspects of Medicine focused on "Bile acids, roles in integrative physiology and pathophysiology".
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Bile acids reduce expression of pro-inflammatory cytokines from monocytes, macrophages, dendritic cells, and Kupffer cells.
“bile acids reduce the expression of pro-inflammatory cytokines from monocytes, macrophages, DCs and the hepatic macrophages known as Kupffer cells (Brestoff and Artis, 2013; Martinot et al., 2017).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Martinot et al., 2017
Bile-acid recycling efficiency depends on microbial biotransformation, while de novo bile-acid synthesis is subject to strict feedback that may limit the effect of increased bile-acid excretion when the microbiota is not fully functional.
“The efficiency of bile-acid recycling depends on their biotransformation by the microbiome; however, the de novo synthesis of bile acids is subject to a strict feedback mechanism, which may limit the effect of increased excretion of bile acids in the absence of a fully functional microbiota (Martinot et al., 2017).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Martinot et al., 2017
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References 111 · Cited by 162
- Authors
- Martinot, E., Sèdes, L., Baptissart, M., Lobaccaro, J.-M., Caira, F., Beaudoin, C., & Volle, D. H.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Volle, David H.
- ORCID
- Venue
- Molecular Aspects of Medicine
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 56
- Pages
- 2-9
- ISSN
- 0098-2997 (ISSN-L)
- OpenAlex
- W3023701859
- Cited by
- 162
- References
- 111
- Citations by year
- 2026: 5 · 2025: 19 · 2024: 29 · 2023: 6 · 2022: 26 · 2021: 19 · 2020: 14 · 2019: 22 · 2018: 16 · 2017: 6
- FWCI
- 1.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Aspects of Medicine (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Keywords
- bile acids, bile acid receptors, TGR5, secondary bile acids, cholesterol metabolism, bile acid signaling, cancer, G protein-coupled receptors, nuclear receptors
- MeSH terms
- Gastrointestinal Microbiome, Receptor, Farnesoid X-Activated, Animals, Bile Acids and Salts, Biotransformation, Cholesterol, Homeostasis, Humans, Intestinal Mucosa, Intestines, Liver, Liver Neoplasms, Polymorphism, Genetic, Signal Transduction, Gene Expression Regulation, Neoplastic, Receptors, Cytoplasmic and Nuclear, Receptors, G-Protein-Coupled
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