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Cited by 429Proteoglycans and glycosaminoglycans researchCellular transport and secretionNanoparticle-Based Drug Delivery

The DOI matches its Crossref record; 54 of the 55 references it cites were found in a registry or an index.

Heparan sulfate proteoglycan as a cell-surface endocytosis receptor

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Christianson, Helena C., Belting, Mattias·2014·Matrix Biology
DOI 10.1016/j.matbio.2013.10.004
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Abstract

How various macromolecules are exchanged between cells and how they gain entry into recipient cells are fundamental questions in cell biology with important implications e.g. non-viral drug delivery, infectious disease, metabolic disorders, and cancer. The role of heparan sulfate proteoglycan (HSPG) as a cell-surface receptor of diverse macromolecular cargo has recently been manifested. Exosomes, cell penetrating peptides, polycation–nucleic acid complexes, viruses, lipoproteins, growth factors and morphogens among other ligands enter cells through HSPG-mediated endocytosis. Key questions that partially have been unraveled over recent years include the respective roles of HSPG core protein and HS chain structure specificity for macromolecular cargo endocytosis, the down-stream intracellular signaling events involved in HSPG-dependent membrane invagination and vesicle formation, and the biological significance of the HSPG transport pathway. Here, we discuss the intriguing role of HSPGs as a major entry pathway of macromolecules in mammalian cells with emphasis on recent in vitro and in vivo data that provide compelling evidence of HSPG as an autonomous endocytosis receptor. • Heparan sulfate proteoglycan (HSPG) is a receptor of diverse macromolecular cargo. • HSPG endocytosis is involved in infectious disease, lipid metabolism and cancer. • HSPG represents an interesting target for macromolecular drug delivery. • Recent findings on the intriguing role of HSPG-mediated transport are discussed.

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Metadata

Authors
Christianson, H. C., & Belting, M.
Affiliations
Lund University (SE)
Corresponding author
Belting, Mattias
ORCID
Belting, Mattias
Venue
Matrix Biology
Publisher
Elsevier BV
Published
2014-04
Volume
35
Pages
51-55
ISSN
0945-053X (ISSN-L)
DOI
10.1016/j.matbio.2013.10.004
OpenAlex
W1980226233
Cited by
429
References
55
Citations by year
2026: 20 · 2025: 29 · 2024: 29 · 2023: 44 · 2022: 43 · 2021: 44 · 2020: 54 · 2019: 37 · 2018: 27 · 2017: 29 · 2016: 30 · 2015: 28 · 2014: 14
FWCI
14.01
Type
journal article
Language
en
Open access
Licence
Locations
  • Matrix Biology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Lund University Publications (Lund University) (submittedVersion)
Funders
  • Swedish Cancer Fund
  • Swedish Research Council
  • Gunnar Nilsson Cancer Foundation
  • Anna Lisa and Sven Eric Lundgren Foundation
  • Kamprad Family Foundation
  • Skåne University Hospital
  • Governmental funding of clinical research within the national health services (ALF)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
heparan sulfate proteoglycans, endocytosis, cell surface receptors, exosomes, cell-penetrating peptides, nucleic acid delivery, viral entry, lipoprotein uptake, growth factor signaling, membrane invagination, intracellular signaling, lipid metabolism, cancer, infectious diseases, drug delivery
MeSH terms
Animals, Biological Transport, Endocytosis, Humans, Ligands, Models, Biological, Receptors, Cell Surface, Signal Transduction, Heparan Sulfate Proteoglycans

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