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Cited by 172Protease and Inhibitor MechanismsChronic Obstructive Pulmonary Disease (COPD) ResearchInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Matrix metalloproteinases in destructive lung disease

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McGarry Houghton, A.·2015·Matrix Biology
DOI 10.1016/j.matbio.2015.02.002
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Abstract

Matrix metalloproteinases (MMPs) play essential physiologic roles in numerous processes ranging from development to wound repair. Unfortunately, given the broad substrate specificity of the MMP family as a whole, aberrant degradation of extracellular matrix proteins can result in destructive disease. Emphysema, the result of destroyed lung elastin and collagen matrix, is the prototypical example of such a destructive process. More recent data has highlighted that MMPs play much more elaborate physiologic and pathophysiologic roles than simple matrix protein cleavage. Key pathophysiological roles for MMPs in emphysema will be discussed herein.

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  • Hyperactivity of MMP12 in the lung can be induced by cigarette smoke in humans and reduces the elasticity of alveoli, which contributes to an incomplete emptying of the lung in chronic obstructive pulmonary disease patients.

    “Hyperactivity of MMP12 in the lung can be induced by cigarette smoke in humans and reduces the elasticity of alveoli, which contributes to an incomplete emptying of the lung in chronic obstructive pulmonary disease patients55.”

    From A genomics approach reveals insights into the importance of gene losses for mammalian adaptations (2018) · cites this paper as [55]

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Authors
McGarry Houghton, A.
Venue
Matrix Biology
Publisher
Elsevier BV
Published
2015-05
Volume
44-46
Pages
167-174
ISSN
0945-053X (ISSN-L)
DOI
10.1016/j.matbio.2015.02.002
OpenAlex
W2110287460
Cited by
172
References
1
Citations by year
2026: 6 · 2025: 6 · 2024: 13 · 2023: 17 · 2022: 17 · 2021: 19 · 2020: 12 · 2019: 24 · 2018: 21 · 2017: 20 · 2016: 14 · 2015: 3
FWCI
1.88
Type
journal article
Language
en
Open access
Licence
Locations
  • Matrix Biology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Keywords
matrix metalloproteinases, emphysema, extracellular matrix degradation, elastin, collagen, lung pathophysiology
MeSH terms
Animals, Collagen, Elastin, Humans, Pulmonary Emphysema, Smoking, Matrix Metalloproteinases

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