Matrix remodeling by MMPs during wound repair
Open accessAbstract
Repair following injury involves a range of processes - such as re-epithelialization, scar formation, angiogenesis, inflammation, and more - that function, often together, to restore tissue architecture. MMPs carry out diverse roles in all of these activities. In this article, we discuss how specific MMPs act on ECM during two critical repair processes: re-epithelialization and resolution of scar tissue. For wound closure, we discuss how two MMPs - MMP1 in human epidermis and MMP7 in mucosal epithelia - facilitate re-epithelialization by cleaving different ECM or ECM-associated proteins to affect similar integrin:matrix adhesion. In scars and fibrotic tissues, we discuss that a variety of MMPs carry out a diverse range of activities that can either promote or limit ECM deposition. However, few of these MMP-driven activities have been demonstrated to be due a direct action on ECM.
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ECM biomaterials are recognized by surrounding cells and gradually degraded by proteolytic enzymes, mainly matrix metalloproteinases (MMP-1, MMP-8, MMP-3, MMP-9).
“On the other hand, ECM biomaterials are recognized by surrounding cells, and, gradually degraded by proteolytic enzymes, mainly matrix metalloproteinases (i.e., MMP-1, MMP-8, MMP-3, MMP-9) [55,56].”
From Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review (2025) · cites this paper as [55]
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References 104 · Cited by 407
- Authors
- Rohani, M. G., & Parks, W. C.
- Affiliations
- Cedars-Sinai Medical Center (US)
- Corresponding author
- Parks, William C.
- Venue
- Matrix Biology
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 44-46
- Pages
- 113-121
- ISSN
- 0945-053X (ISSN-L)
- OpenAlex
- W2034166961
- Cited by
- 407
- References
- 104
- Citations by year
- 2026: 22 · 2025: 47 · 2024: 29 · 2023: 21 · 2022: 41 · 2021: 48 · 2020: 43 · 2019: 39 · 2018: 39 · 2017: 51 · 2016: 21 · 2015: 6
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Matrix Biology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- matrix metalloproteinases, extracellular matrix remodeling, wound healing, re-epithelialization, scar formation, fibrosis, MMP-1, MMP-7, human epidermis
- MeSH terms
- Animals, Cicatrix, Extracellular Matrix, Humans, Wound Healing, Wounds and Injuries, Gene Expression Regulation, Enzymologic, Matrix Metalloproteinases, Re-Epithelialization
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