Enzymatic and non-enzymatic functions of the lysyl oxidase family in bone
Open accessAbstract
Advances in the understanding of the biological roles of the lysyl oxidase family of enzyme proteins in bone structure and function are reviewed. This family of proteins is well-known as catalyzing the final reaction required for cross-linking of collagens and elastin. Novel emerging roles for these proteins in the phenotypic development of progenitor cells and in angiogenesis are highlighted and which point to enzymatic and non-enzymatic roles for this family in bone development and homeostasis and in disease. The explosion of interest in the lysyl oxidase family in the cancer field highlights the need to have a better understanding of the functions of this protein family in normal and abnormal connective tissue homeostasis at fundamental molecular and cellular levels including in mineralized tissues.
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References 101 · Cited by 86
- Authors
- Trackman, P. C.
- Affiliations
- Boston University (US)
- Corresponding author
- Trackman, Philip C.
- ORCID
- Trackman, Philip C.
- Venue
- Matrix Biology
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 52-54
- Pages
- 7-18
- ISSN
- 0945-053X (ISSN-L)
- PMC
- PMC4875786
- OpenAlex
- W2231703142
- Cited by
- 86
- References
- 101
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 8 · 2023: 8 · 2022: 7 · 2021: 8 · 2020: 9 · 2019: 12 · 2018: 11 · 2017: 10 · 2016: 1
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Matrix Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH/NIDCR (R01DE014066, R21DE023973)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
- Keywords
- bone, collagen cross-linking, elastin cross-linking, non-enzymatic function, skeletal development, bone homeostasis, bone disease, angiogenesis, progenitor cells, mineralized tissue, cancer
- MeSH terms
- Animals, Bone and Bones, Collagen, Elastin, Humans, Protein-Lysine 6-Oxidase, Neoplasms, Stem Cells, Neovascularization, Physiologic
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