Core-shell chitosan microsphere with antimicrobial and vascularized functions for promoting skin wound healing
Open accessAbstract
It is imperative to develop a wound dressing that can effectively treat bacterial infection in the wound location and speed up wound healing. In this study, chitosan (CS) microspheres with a core–shell structure were prepared using high-voltage electrostatic drop technology. The antimicrobial polypeptide (PonG1) and bFGF, were encapsulated in the core of the CS microsphere. The preparation of CS microspheres was studied by changing the parameters. The surface morphology of CS microspheres and the release quantities of PonG1 and bFGF were observed and detected. In vivo experiments were conducted to study the neovascularization and anti-inflammatory abilities of bFGF and PonG1. The repair ability of CS microspheres was evaluated using a rat model of full-thickness skin wound. Both bFGF and PonG1 exhibited slow release from the CS microspheres within 14 days. In vivo experiments showed that CS microspheres containing PonG1 (3 mg/ml) and bFGF (300 μg/ml) had the best neovascularization and anti-inflammatory effects. CS microspheres containing both bFGF and PonG1 had the strongest ability to repair skin wound. CS microspheres with antimicrobial and vascularized functions can be used as dressings for the repair of hard-to-heal wounds.
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Chitosan promotes angiogenesis, granulation tissue formation, and re-epithelialization, aiding tissue recovery.
“It promotes angiogenesis, granulation tissue formation, and re-epithelialization, aiding tissue recovery [169,170].”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [170]
Section 3.8 (page unavailable) reports angiogenesis, faster epidermal reconstruction, and improved wound closure with chitosan microspheres containing bFGF and PonG1. It does not report granulation tissue formation, and the angiogenesis and epidermal findings concern the loaded microspheres rather than chitosan alone. (LLM, conf=0.86)
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Research works printed but not linked: 3
- L.I. Moura, A.M. Dias, E. Carvalho, H.C. de Sousa, Recent advances on the development of wound dressings for diabetic foot ulcer treatment-a review, Acta Biomater 9 (7) (2013) 7093-7114.
- N. Woodford, D.M. Livermore, Infections caused by Gram-positive bacteria: a review of the global challenge, J Infect 59 (Suppl 1) (2009) S4-S16.
- D. Simões, S.P. Miguel, M.P. Ribeiro, P. Coutinho, A.G. Mendonça, I.J. Correia, Recent advances on antimicrobial wound dressing: A review, Eur J Pharm Biopharm 127 (2018) 130-141.
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Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering
Fazel Anvari-Yazdi, A., Badea, I., & Chen, X. (2025) · Gels · doi:10.3390/gels11060441 · Cited by 20 · see citing works
- Authors
- Li, H., & Wang, F.
- Affiliations
- Beijing Institute of Technology (CN)
- Corresponding author
- Wang, Feng
- ORCID
- Venue
- Materials & Design
- Publisher
- Elsevier BV
- Published
- 2021-06
- Volume
- 204
- Pages
- 109683
- ISSN
- 0264-1275 (ISSN-L)
- OpenAlex
- W3142610935
- Cited by
- 95
- References
- 0
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 14 · 2023: 14 · 2022: 44 · 2021: 6
- FWCI
- 10.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Materials & Design (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Beijing Institute of Technology Research Fund Program for Young Scholars
- National Natural Science Foundation of China (21736002, 31770827)
- National Key Research and Development Program of China (2016YFC0906000)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- chitosan microspheres, core-shell microspheres, wound dressings, skin wound healing, basic fibroblast growth factor, neovascularization, anti-inflammatory activity, controlled drug release, bacterial wound infection, full-thickness skin wounds
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