Surface-Engineered Chlorella Alleviated Hypoxic Tumor Microenvironment for Enhanced Chemotherapy and Immunotherapy of First-Line Drugs
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Chlorella sp. cells coated with macrophage membrane (M-Chl) enhanced tumor accumulation and retention due to inflammatory homing effects and achieved continuous O2 production for at least 6 days, downregulating tumor HIF-1α.
“A continuous production of O2 was achieved for at least 6 days, resulting in an efficient downregulation of tumor HIF-1α.”
From Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp. (2023) · cites this paper as [168]
In melanoma mice, DOX alone had unsatisfactory antitumor effects, but its therapeutic effect significantly improved in mice treated with M-Chl for tumor oxygenation.
“In vivo antitumor chemotherapy showed that DOX exhibited unsatisfactory antitumor effects in melanoma mice, but its therapeutic effect significantly improved in the mice treated with M-Chl for tumor oxygenation.”
From Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp. (2023) · cites this paper as [168]
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References 48 · Cited by 39
- Authors
- Gao, C., Kwong, C. H. T., Wang, Q., Kam, H., Wei, J., Chen, Q., Zhang, J., Lee, S. M. Y., Gu, D., & Wang, R.
- Affiliations
- University of Macau (MO)
- Shenzhen University (CN)
- Corresponding author
- Lee, Simon M.Y.
- Wang, Ruibing
- Venue
- Materials Today
- Publisher
- Elsevier BV
- Published
- 2022-09
- Volume
- 58
- Pages
- 57-70
- ISSN
- 1369-7021 (ISSN-L)
- OpenAlex
- W4287843586
- Cited by
- 39
- References
- 48
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 9 · 2023: 7
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Materials Today (publishedVersion)
- Funders
- Basic and Applied Basic Research Foundation of Guangdong Province (2020A1515110744, 2020A1515110871)
- National Natural Science Foundation of China (32001016)
- Science, Technology and Innovation Commission of Shenzhen Municipality (SGDX20210823103803027)
- Shenzhen Technology Development Program (GJHZ20200731095604013, JCYJ20210324102803009, JCYJ20210324103204011, RCBS20200714114856016)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- Chlorella, tumor hypoxia, tumor microenvironment, macrophage membrane coating, photosynthetic oxygen production, targeted tumor delivery, HIF-1α, doxorubicin, multidrug resistance, anti-CTLA-4 antibody, tumor immunosuppression, T cell activation, solid tumors, surface engineering
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