Association of endometriosis-related infertility with age at menopause
Abstract
Objective The influence of past history of infertility, which is closely associated with reproductive factors, on menopause has not been clarified. The purpose of this study was to clarify the association of reproductive factors, including past history of infertility, with menopause in Japanese women. Study design This study was a cross-sectional analysis of the Japan Nurses' Health Study (JNHS) baseline survey. The JNHS is a nationwide prospective cohort study on the health of Japanese women, and the baseline survey was conducted between 2001 and 2007. Main outcome measure We analyzed data for 24,153 pre- and postmenopausal women who were enrolled in the JNHS at the ages 40-59 years. The main outcome measure was menopause. Results Reproductive factors influencing the onset of natural menopause were past history of infertility [relative risk (RR) (age-adjusted odds ratio and 95% confidence interval): 1.28 (1.10-1.48)], past history of endometriosis: 1.32 (1.07-1.64), age at menarche: 0.919 (0.886-0.953) and number of pregnancies: 0.943 (0.911-0.976). Endometriosis as the cause of infertility was significantly associated with earlier onset of menopause (3.43 [2.17-5.44]) after adjustment for age. The strong association of past history of infertility related to endometriosis was still significant after multivariate adjustment. Conclusion Menopause in women who have a past history of infertility, especially in those who have suffered from endometriosis, is significantly earlier…
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Women with endometriosis reach menopause at significantly earlier ages than unaffected women.
“Women with endometriosis reach menopause at significantly earlier ages than unaffected women (Pokoradi et al., 2011; Yasui et al., 2011),”
From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Yasui et al., 2011
Cites
The Relation of Endometriosis to Menstrual Characteristics, Smoking, and Exercise
Cramer, D. W. (1986) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1986.03370140102032 · Cited by 367 · see citing works
Lemos, N. A., Arbo, E., Scalco, R., Weiler, E., Rosa, V., & Cunha-Filho, J. S. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.04.048 · Cited by 110 · see citing works
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Endometriosis and polycystic ovary syndrome are diametric disorders
Dinsdale, N. L., & Crespi, B. J. (2021) · Evolutionary Applications · doi:10.1111/eva.13244 · Cited by 90 · see citing works
“Women with endometriosis reach menopause at significantly earlier ages than unaffected women (Pokoradi et al., 2011; Yasui et al., 2011), whereas women with PCOS reach menopause significantly later than unaffected women (Forslund et al., 2019; Minooee et al., 2018; Tehrani et al., 2010).”
BackgroundRuth, K. S., Beaumont, R. N., Tyrrell, J., Jones, S. E., Tuke, M. A., Yaghootkar, H., Wood, A. R., Freathy, R. M., Weedon, M. N., Frayling, T. M., et al. (2016) · Human Reproduction · doi:10.1093/humrep/dev318 · Cited by 70 · see citing works
Endometriosis: a life cycle approach?
Brosens, I., Puttemans, P., & Benagiano, G. (2013) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2013.03.009 · Cited by 66 · see citing works
- Authors
- Yasui, T., Hayashi, K., Mizunuma, H., Kubota, T., Aso, T., Matsumura, Y., Lee, J.-S., & Suzuki, S.
- Affiliations
- Tokushima University (JP)
- Gunma University (JP)
- Hirosaki University (JP)
- Tokyo Medical and Dental University (JP)
- Kiryu University (JP)
- The University of Tokyo (JP)
- Venue
- Maturitas
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 69
- Issue
- 3
- Pages
- 279-283
- ISSN
- 0378-5122 (ISSN-L)
- OpenAlex
- W2119331560
- Cited by
- 43
- References
- 2
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Maturitas (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Japan Society for the Promotion of Science (22390128, 20240063)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- endometriosis, infertility, menopause, age at menopause, age at menarche, number of pregnancies, reproductive factors
- MeSH terms
- Adult, Age Factors, Endometriosis, Female, Health Surveys, Humans, Infertility, Female, Japan, Menarche, Menopause, Middle Aged, Pregnancy, Prospective Studies, Gravidity
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