Pasireotide (SOM230): Development, mechanism of action and potential applications

Schmid, Herbert A.·2008·Molecular and Cellular Endocrinology

Cited by (256)

Items 101–200 of 256

  1. Pasireotide Therapy of Multiple Endocrine Neoplasia Type 1–Associated Neuroendocrine Tumors in Female Mice Deleted for an Men1 Allele Improves Survival and Reduces Tumor Progression
    G. Walls, M. Stevenson, B. Soukup, K. Lines, A. Grossman, H. Schmid, R. Thakker · 2016 · Endocrinology
  2. Pasireotide for the treatment of acromegaly
    L. Wildemberg, M. Gadelha · 2016 · Expert Opinion on Pharmacotherapy
  3. Unusual complication of a pancreatic neuroendocrine tumor presenting with malignant hypercalcemia.
    G. Kanakis, G. Kaltsas, D. Granberg, Lars Grimelius, D. Papaioannou, A. Tsolakis, K. Öberg · 2012 · Journal of Clinical Endocrinology and Metabolism
  4. Octreotide SC depot in patients with acromegaly and functioning neuroendocrine tumors: a phase 2, multicenter study
    M. Pavel, F. Borson-Chazot, A. Cailleux, D. Hörsch, H. Lahner, R. Pivonello, L. Tauchmanovà, C. Darstein, H. Olsson, F. Tiberg et al. · 2018 · Cancer Chemotherapy and Pharmacology
  5. Inhibition of Peripheral Synthesis of Serotonin as a New Target in Neuroendocrine Tumors.
    J. Molina-Cerrillo, T. Alonso-Gordoa, O. Martínez-Sáez, E. Grande · 2016 · The Oncologist
  6. Extremophilic proteases as novel and efficient tools in short peptide synthesis
    A. Białkowska, K. Morawski, T. Florczak · 2017 · Journal of Industrial Microbiology & Biotechnology
  7. Paraneoplastic Cushing syndrome, case-series and review of the literature
    Annelies Deldycke, C. Haenebalcke, Y. Taes · 2018 · Acta Clinica Belgica
  8. Somatostatin analogs and chimeric somatostatin-dopamine molecules differentially regulate human growth hormone and prolactin gene expression and secretion in vitro.
    A. Gruszka, M. Culler, S. Melmed · 2012 · Molecular and Cellular Endocrinology
  9. Absence of somatostatin SST2 receptor internalization in vivo after intravenous SOM230 application in the AR42J animal tumor model
    Beatrice Waser, Renzo Cescato, Maria‐Luisa Tamma, Helmut R. Maëcke, Jean Claude Reubi · 2010 · European Journal of Pharmacology
  10. Endocrine hypertension — Current understanding and comprehensive management review
    Norlela Sukor · 2011 · European Journal of Internal Medicine
  11. Co-expression of somatostatin receptor subtypes and estrogen receptor-α mRNAs by non-functioning pituitary adenomas in young patients.
    H. Nishioka, K. Tamura, Haruka Iida, M. Kutsukake, A. Endo, Y. Ikeda, J. Haraoka · 2011 · Molecular and Cellular Endocrinology
  12. Pasireotide is more effective than octreotide, alone or combined with everolimus on human meningioma in vitro
    T. Graillon, D. Romano, Céline Défilles, Christophe Lisbonis, A. Saveanu, D. Figarella-Branger, P. Roche, S. Fuentès, O. Chinot, H. Dufour et al. · 2017 · OncoTarget
  13. Novel Somatostatin Receptor Ligands Therapies for Acromegaly
    R. Paragliola, R. Salvatori · 2018 · Frontiers in Endocrinology
  14. Pasireotide for the treatment of Cushing's disease
    Giorgio Arnaldi, Marco Boscaro · 2010 · Expert Opinion on Investigational Drugs
  15. Magnetic resonance imaging as a predictor of therapeutic response to pasireotide in acromegaly
    Sabina Ruiz, J. Gil, B. Biagetti, E. Venegas, R. Cámara, Rogelio García-Centeno, M. Gálvez, A. Picó, Silvia Maraver, I. Gonzalez et al. · 2023 · Clinical Endocrinology
  16. Beneficial effect of combined treatment with octreotide and pasireotide in PCK rats, an orthologous model of human autosomal recessive polycystic kidney disease
    M. Kugita, K. Nishii, Tamio Yamaguchi, A. Suzuki, Y. Yuzawa, S. Horie, E. Higashihara, S. Nagao · 2017 · PLoS ONE
  17. [111In-DOTA]LTT-SS28, a First Pansomatostatin Radioligand for in Vivo Targeting of Somatostatin Receptor-Positive Tumors
    Θεοδοσία Μάινα, Renzo Cescato, Beatrice Waser, Aikaterini Tatsi, Aikaterini Kaloudi, Eric P. Krenning, Marion de Jong, Berthold A. Nock, Jean Claude Reubi · 2014 · Journal of Medicinal Chemistry
  18. Targeting the somatostatin receptor in pituitary and neuroendocrine tumors
    Marije J. Veenstra, W. D. de Herder, R. Feelders, L. Hofland · 2013 · Expert opinion on therapeutic targets
  19. Pasireotide (SOM230) protects the retina in animal models of ischemia induced retinopathies
    Despina Kokona, Niki Mastrodimou, Iosif Pediaditakis, Ioannis Charalampopoulos, HERBERT A. SCHMID, Kyriaki Thermos · 2012 · Experimental Eye Research
  20. Multiple once-daily subcutaneous doses of pasireotide were well tolerated in healthy male volunteers: a randomized, double-blind, placebo-controlled, cross-over, Phase I study
    C. Beglinger, K. Hu, Ying Wang, E. Bouillaud, C. Darstein, Yan-Feng Wang, P. Mohideen · 2012 · Endocrine
  21. BILN: A Human-Readable Line Notation for Complex Peptides
    Thomas Fox, M. Bieler, P. Haebel, Rodrigo Ochoa, Stefan Peters, Alexander Weber · 2022 · Journal of Chemical Information and Modeling
  22. Phase I dose-escalation study of long-acting pasireotide in patients with neuroendocrine tumors
    James C. Yao, J. Chan, A. Mita, M. Kundu, Karina Hermosillo Reséndiz, K. Hu, Shoba Ravichandran, J. Strosberg, E. Wolin · 2017 · OncoTargets and Therapy
  23. Management of neuroendocrine tumors
    Clement Chung · 2016 · American Journal of Health-System Pharmacy
  24. The clinical significance of somatostatin in pancreatic diseases.
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  25. Involvement of bone morphogenetic protein activity in somatostatin actions on ovarian steroidogenesis.
    Eri Nakamura, F. Otsuka, K. Inagaki, Naoko Tsukamoto, K. Ogura-Ochi, T. Miyoshi, Kishio Toma, M. Takeda, H. Makino · 2013 · Journal of Steroid Biochemistry and Molecular Biology
  26. Somatostatin-Dopamine Chimeric Molecules in Neuroendocrine Neoplasms
    M. C. Cantone, A. Dicitore, G. Vitale · 2021 · Journal of Clinical Medicine
  27. A Macrophage Membrane–Polymer Hybrid Biomimetic Nanoplatform for Therapeutic Delivery of Somatostatin Peptide to Chronic Pancreatitis
    Fang Wang, Yu Deng, Luying Yu, Ao Zhou, Jieting Wang, Jingyan Jia, Ning Li, Fadian Ding, Wei Lian, Qicai Liu et al. · 2022 · Pharmaceutics
  28. Octreotide-Resistant Acromegaly: Challenges and Solutions
    G. Corica, M. Ceraudo, Claudia Campana, F. Nista, F. Cocchiara, M. Boschetti, G. Zona, Diego Criminelli, D. Ferone, F. Gatto · 2020 · Therapeutics and Clinical Risk Management
  29. Structural modifications of amino acid sequences of radiolabeled peptides for targeted tumor imaging
    Fariba Maleki, Arezou Masteri Farahani, Farzaneh Rezazedeh, Nourollah Sadeghzadeh · 2020 · Bioorganic Chemistry
  30. Pathophysiology of Gastric NETs: Role of Gastrin and Menin
    Sinju Sundaresan, Anthony J. Kang, Juanita L. Merchant · 2017 · Current Gastroenterology Reports
  31. New therapeutic approaches to metastatic gastroenteropancreatic neuroendocrine tumors: A glimpse into the future
    E. U. Cidon · 2017 · World Journal of Gastrointestinal Oncology
  32. Expert consensus for the management of advanced or metastatic pancreatic neuroendocrine and carcinoid tumors
    D. Castellano, E. Grande, J. Valle, J. Capdevila, D. Reidy-Lagunes, J. O'Connor, E. Raymond · 2015 · Cancer Chemotherapy and Pharmacology
  33. The Neuropeptide Systems and their Potential Role in the Treatment of Mammalian Retinal Ischemia: A Developing Story
    Davide Cervia, G. Casini · 2013 · Current Neuropharmacology
  34. Tolerability and dose proportional pharmacokinetics of pasireotide administered as a single dose or two divided doses in healthy male volunteers: a single-center, open-label, ascending-dose study.
    S. Petersenn, K. Hu, M. Maldonado, Yilong Zhang, J. Lasher, E. Bouillaud, Yan-Feng Wang, K. Mann, N. Unger · 2012 · Clinical Therapeutics
  35. Nelson syndrome: definition and management.
    Thomas M. Barber, E. Adams, J. A. Wass · 2014 · Handbook of Clinical Neurology
  36. Progress in the Stereoselective Synthesis Methods of Pyrrolidine-Containing Drugs and Their Precursors
    Аndrey V. Smolobochkin, Almir Sabirovich Gazizov, Nurbol Orynbasaruly Appazov, Oleg Gerol'dovich Sinyashin, Alexander Romanovich Burilov · 2024 · International Journal of Molecular Sciences
  37. The Effects of Peptide Receptor Radionuclide Therapy on the Neoplastic and Normal Pituitary
    P. Marques · 2023 · Cancers
  38. Phase I Trial of the Combination of Docetaxel, Prednisone, and Pasireotide in Metastatic Castrate-Resistant Prostate Cancer
    M. Thakur, L. Heilbrun, Kimberlee Dobson, J. Boerner, K. Stark, Jing Li, D. Smith, E. Heath, J. Fontana, U. Vaishampayan · 2018 · Clinical Genitourinary Cancer
  39. Pasireotide does not improve efficacy of aspiration sclerotherapy in patients with large hepatic cysts, a randomized controlled trial
    T. Wijnands, T. Gevers, M. Lantinga, R. T. Te Morsche, L. Schultze Kool, J. Drenth · 2018 · European Radiology
  40. Pasireotide in Acromegaly: An Overview of Current Mechanistic and Clinical Data
    S. Samson · 2015 · Neuroendocrinology
  41. Evolving Treatment Strategies for Management of Carcinoid Tumors
    Jonathan Strosberg · 2013 · Current Treatment Options in Oncology
  42. New formulations and approaches in the medical treatment of acromegaly
    M. Debono, J. Newell-Price · 2010 · Current Opinion in Endocrinology, Diabetes & Obesity
  43. Prognostic role of neuroendocrine differentiation in prostate cancer, putting together the pieces of the puzzle
    A. Berruti, F. Vignani, L. Russo, V. Bertaglia, Mattia Tullio, M. Tucci, M. Poggio, L. Dogliotti · 2010 · Open Access Journal of Urology
  44. Current therapy and drug pipeline for the treatment of patients with acromegaly
    S. Kumar, J. Ayuk, R. Murray · 2009 · Advances in Therapy
  45. Revisiting C.G. Moertel's land of small tumors.
    L. Kvols · 2008 · Journal of Clinical Oncology
  46. Long-term efficacy and safety of subcutaneous pasireotide alone or in combination with cabergoline in Cushing’s disease
    R. Feelders, M. Fleseriu, P. Kadıoğlu, M. Bex, D. González-Devia, C. Boguszewski, Dilek Gogas Yavuz, Heather Patino, A. Pedroncelli, R. Maamari et al. · 2023 · Frontiers in Endocrinology
  47. Pasireotide effects on biochemical control and glycometabolic profile in acromegaly patients switched from combination therapies or unconventional dosages of somatostatin analogs
    G. Corica, R. Pirchio, A. Milioto, F. Nista, A. Arecco, L. Mattioli, R. Auriemma, F. Cocchiara, R. Pivonello, A. Colao et al. · 2023 · Journal of Endocrinological Investigation
  48. Therapy Resistant Gastroenteropancreatic Neuroendocrine Tumors
    Kristen V. McClellan, Emerson Yu-sheng Chen, Adel Kardosh, Charles D. Lopez, Jaydira Del Rivero, Nadine Mallak, Flavio G. Rocha, Yilun Koethe, Rodney F. Pommier, Erik Mittra et al. · 2022 · Cancers
  49. The pivotal role of mammalian target of rapamycin inhibition in the treatment of patients with neuroendocrine tumors
    Alexandria T. Phan, Bhuvanesh Dave · 2016 · Cancer Medicine
  50. Pharmacokinetics and safety of subcutaneous pasireotide and intramuscular pasireotide long-acting release in Chinese male healthy volunteers: a phase I, single-center, open-label, randomized study.
    Xia Chen, Guo-Xiang Shen, Ji Jiang, Hong-Zhong Liu, K. Hu, C. Darstein, J. Lasher, P. Hu · 2014 · Clinical Therapeutics
  51. Lower 68Ga‐DOTATOC uptake in nonfunctioning pituitary neuroendocrine tumours compared to normal pituitary gland—A proof‐of‐concept study
    Axel Tjörnstrand, Olivera Casar‐Borota, Kerstin Heurling, Michael Schöll, Peter Gjertsson, Jakob Himmelman, Oleksiy Itsenko, Óskar Ragnarsson, Helena Filipsson Nyström · 2019 · Clinical Endocrinology
  52. Evaluation of preclinical efficacy of everolimus and pasireotide in thyroid cancer cell lines and xenograft models
    Taofeek Kunle Owonikoko, Guojing Zhang, Shenila B. Lallani, Zhengjia Chen, Deborah E. Martinson, Fadlo Raja Khuri, Sagar Lonial, Adam I. Marcus, Shi‐Yong Sun · 2019 · PLoS ONE
  53. Medical Management of Pancreatic Neuroendocrine Tumors: Current and Future Therapy.
    J. Chan, M. Kulke · 2016 · Surgical Oncology Clinics of North America
  54. A systematic review of management of neuroendocrine tumors: An experience from a tertiary care centre from India
    R. Kapoor, T. Bhattacharyya, R. Gupta, B. Mittal, N. Kalra · 2014
  55. Systemic Therapy for Advanced Pancreatic Neuroendocrine Tumors
    M. Kulke · 2013 · Seminars in Oncology
  56. The Synergistic Effect of Pasireotide and Teriflunomide in Carcinoids in vitro
    Y. Somnay, Herb Chen, M. Kunnimalaiyaan · 2012 · Neuroendocrinology
  57. Structural insights into somatostatin receptor 5 bound with cyclic peptides
    Ying-Ge Li, Xiang-Hui Meng, Xi-Ru Yang, Sheng-Long Ling, Pan Shi, Changlin Tian, Fan Yang · 2024 · Acta Pharmacologica Sinica
  58. Outcomes of peri-operative glucocorticosteroid use in major pancreatic resections: a systematic review.
    Li-Lian Kuan, A. Dennison, G. Garcea · 2021 · HPB
  59. Applications of peptide hormone ligands for the treatment of dumping and short bowel syndrome
    Lucas I. Wauters, Tim Vanuytsel · 2018 · Current Opinion in Pharmacology
  60. When and How to Use Somatostatin Analogues.
    W. D. de Herder · 2018 · Endocrinology and metabolism clinics of North America (Print)
  61. Treatment of a thyrotropin‐secreting pituitary adenoma (TSH‐oma) with pasireotide LAR
    Marlise E. A. van Eersel, Susanne H. Meeuwisse-Pasterkamp, A. Muller Kobold, L. Meiners, W. D. den Dunnen, L. Hofland, G. van den Berg · 2017 · Clinical Endocrinology
  62. Effect of AP102, a subtype 2 and 5 specific somatostatin analog, on glucose metabolism in rats
    E. Tarasco, Petra Seebeck, Svende Pfundstein, A. Daly, Philippe J. Eugster, A. Harris, E. Grouzmann, T. Lutz, C. Boyle · 2017 · Endocrine
  63. Investigational therapies for acromegaly
    L. Grasso, R. Pivonello, A. Colao · 2013 · Expert Opinion on Investigational Drugs
  64. Recent advances in the diagnosis and treatment of gastrointestinal carcinoids.
    Joe Valentino, B. M. Evers · 2011 · Advances in Surgery
  65. Release kinetics of somatostatin from self‐assembled nanostructured hydrogels
    U. Rai, T. Thrimawithana, D. Dharmadana, C. Valéry, S. Young · 2018 · Biopolymers
  66. A first-in-man study to evaluate the safety, tolerability, and pharmacokinetics of pasireotide (SOM230), a multireceptor-targeted somatostatin analog, in healthy volunteers
    G. Golor, K. Hu, M. Ruffin, A. Buchelt, E. Bouillaud, Yan-Feng Wang, M. Maldonado · 2012 · Drug Design, Development and Therapy
  67. Effect of Hepatic Impairment on the Pharmacokinetics of Pasireotide (SOM230): Results From a Multicenter Phase I Study
    Y. Horsmans, K. Hu, M. Ruffin, Ying Wang, D. Song, E. Bouillaud, Yan-Feng Wang, D. Mazur, F. Botha, D. Heuman · 2012 · Journal of clinical pharmacology
  68. Optimizing acromegaly treatment.
    M. Bronstein · 2010 · Frontiers of Hormone Research
  69. Somatostatin analogue pasireotide (SOM230) inhibits catecholamine secretion in human pheochromocytoma cells.
    L. Streit, S. Moog, S. Hugel, Marion Rame, Émeline Tanguy, V. Andry, H. Schmid, L. Brunaud, F. Bihain, C. Nominé-Criqui et al. · 2021 · Cancer Letters
  70. Evolution in the treatment of gastroenteropancreatic-neuroendocrine neoplasms, focus on systemic therapeutic options: a systematic review.
    S. Pusceddu, F. De Braud, F. Festinese, Cristina Bregant, A. Lorenzoni, M. Maccauro, M. Milione, L. Concas, B. Formisano, Livia Leuzzi et al. · 2015 · Future Oncology
  71. The Effect of Albumin Fusion Patterns on the Production and Bioactivity of the Somatostatin-14 Fusion Protein in Pichia pastoris
    Yue-Di Ding, Jun Fan, Wenxin Li, Run-Lin Yang, Ying Peng, L. Deng, Yu Wu, Qiang Fu · 2013 · Applied Biochemistry and Biotechnology
  72. Zoledronic acid but not somatostatin analogs exerts anti‐tumor effects in a model of murine prostatic neuroendocrine carcinoma of the development of castration‐resistant prostate cancer
    K. Hashimoto, N. Masumori, Toshiaki Tanaka, Toshihiro Maeda, K. Kobayashi, H. Kitamura, K. Hirata, T. Tsukamoto · 2013 · The Prostate
  73. Update on the management of neuroendocrine tumors: focus on somatostatin antitumor effects.
    Nancy M Gardner-Roehnelt · 2012 · Clinical Journal of Oncology Nursing
  74. Preclinical evidences suggest new treatment options for endocrine disorders: Pasireotide (SOM230) and Everolimus (RAD001).
    H. Schmid · 2008 · Annales d'Endocrinologie
  75. VX‐809 mitigates disease in a mouse model of autosomal dominant polycystic kidney disease bearing the R3277C human mutation
    Murali K. Yanda, Liudmila Cebotaru · 2021 · The FASEB Journal
  76. The impact of SST2 trafficking and signaling in the treatment of pancreatic neuroendocrine tumors
    Eleonora Vitali, Sara Piccini, Giampaolo Trivellin, Valeria Smiroldo, Elisabetta Lavezzi, Alessandro Zerbi, Giovanna Pepe, Andrea Gerardo Lania · 2021 · Molecular and Cellular Endocrinology
  77. The position of combined medical treatment in acromegaly
    Eva C. Coopmans, S. V. van Meyel, A. J. van der Lely, S. Neggers · 2019 · Archives of Endocrinology and Metabolism
  78. Is receptor profiling useful for predicting pituitary therapy?
    M. Marazuela, A. Ramos-Leví, Patricia Borges de Souza, M. Zatelli · 2018 · European Journal of Endocrinology
  79. New Treatments for the Carcinoid Syndrome.
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  80. Somatostatin analogs, cabergoline and pegvisomant: comparing the efficacy of medical treatment for acromegaly
    L. Grasso, R. Auriemma, R. Pivonello, A. Colao · 2017 · Expert Review of Endocrinology & Metabolism
  81. Octreotide long-acting repeatable for acromegaly
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  82. Management of neuroendocrine tumors: current and future therapies
    Kjell E. Öberg · 2010 · Expert Review of Endocrinology & Metabolism
  83. New treatment guidelines on Cushing's disease
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  84. Long-term pasireotide therapy in acromegaly: extensive real-life experience of a referral center
    R. Pirchio, R. Auriemma, A. Vergura, R. Pivonello, A. Colao · 2024 · Journal of Endocrinological Investigation
  85. Rapid response of Nelson’s syndrome to pasireotide in radiotherapy-naive patient
    Xin He, Joanna L. Spencer-Segal · 2020 · Clinical Diabetes and Endocrinology
  86. Somatostatin Agonist Pasireotide Inhibits Exercise‐Stimulated Growth in the Male Siberian Hamster (Phodopus sungorus)
    Rebecca Dumbell, Ines Petri, Frank Scherbarth, Victoria Diedrich, HERBERT A. SCHMID, Stephan Steinlechner, Perry Barrett · 2016 · Journal of Neuroendocrinology
  87. Aspiration sclerotherapy combined with pasireotide to improve reduction of large symptomatic hepatic cysts (SCLEROCYST): study protocol for a randomized controlled trial
    T. Wijnands, T. Gevers, L. Schultze Kool, J. Drenth · 2015 · Trials
  88. The effect of albumin fusion structure on the production and bioactivity of the somatostatin-28 fusion protein in Pichia pastoris
    Yue-Di Ding, Jun Fan, Wenxin Li, Ying Peng, Run-Lin Yang, L. Deng, Qiang Fu · 2014 · Journal of Industrial Microbiology & Biotechnology
  89. Application of triple quadrupole tandem mass spectrometry to the bioanalysis of collision-induced dissociation-resistant cyclic peptides - Ultra-sensitive quantification of the somatostatin-analog pasireotide utilizing UHPLC-MS/MS.
    M. Sauter, Philipp Uhl, J. Burhenne, W. Haefeli · 2020 · Journal of Pharmaceutical and Biomedical Analysis
  90. Update on management of midgut neuroendocrine tumors
    Amir Mehrvarz Sarshekeh, D. Halperin, A. Dasari · 2016 · International Journal of Endocrine Oncology
  91. Pasireotide (SOM230): a novel pituitary-targeted medical therapy for the treatment of patients with Cushing’s disease
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  92. Neuroendokrine Tumoren des Gastrointestinaltraktes
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  93. Pasireotide-induced hyperglycemia in Cushing’s disease and Acromegaly: A clinical perspective and algorithms proposal
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  94. Resistance of neuroendocrine tumours to somatostatin analogs
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  95. A Multicenter Randomized Phase II Study of Single Agent Efficacy and Optimal Combination Sequence of Everolimus and Pasireotide LAR in Advanced Thyroid Cancer
    J. Bauman, Zheng-Jia Chen, Chao Zhang, J. Ohr, R. Ferris, Gerald M. McGorisk, S. Brandt, S. Srivatsa, Amy Y. Chen, C. Steuer et al. · 2022 · Cancers
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  97. SOMATOSTATIN ANALOGUES FOR THE TREATMENT OF NEUROENDOCRINE TUMOURS. DOSAGE FORMS AND ROUTES OF ADMINISTRATION (REVIEW)
    Z. Shprakh · 2020 · International Journal of Applied Pharmaceutics
  98. Diagnostic accuracy of technetium-99m-octreotide in imaging neuroendocrine tumors, Oman hospital experience with literature review
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  99. Synthesis and binding affinities for sst receptors of cyclic peptoid SRIF-mimetics
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  100. Advances in the therapy of gastroenteropancreatic-neuroendocrine tumours (GEP-NETs)
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