Potential role of estrogen in regulation of the Insulin-like growth factor2–H19 locus in the rat testis

Pathak, Shilpa; D'Souza, Ryan; Ankolkar, Mandar; Gaonkar, Reshma; Balasinor, Nafisa H.

doi:10.1016/j.mce.2009.08.005

Potential role of estrogen in regulation of the Insulin-like growth factor2–H19 locus in the rat testis

The selective estrogen receptor modulator, tamoxifen, has been shown to reduce DNA methylation at Insulin-like growth factor 2/H19 differentially methylated region (Igf2/H19 DMR) in the spermatozoa of the Holtzman rats. Since imprint at this locus is acquired during spermatogenesis in the male ge…