X-3, a mangiferin derivative, stimulates AMP-activated protein kinase and reduces hyperglycemia and obesity in db/db mice

Han, Jun; Yi, Jia; Liang, Fengying; Jiang, Bo; Xiao, Ying; Gao, Shouhong; Yang, Na; Hu, Honggang; Xie, Wei-Fen; Chen, Wansheng

doi:10.1016/j.mce.2015.02.008

X-3, a mangiferin derivative, stimulates AMP-activated protein kinase and reduces hyperglycemia and obesity in db/db mice

Diabetes mellitus is a major health concern, affecting nearly 10% of the population. Here we describe a potential novel therapeutic agent for this disease, X-3, a derivative of mangiferin. Therapeutic administration of X-3 significantly and dose-dependently reduced plasma glucose and triglyceride…