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Cited by 112Estrogen and related hormone effectsMenopause: Health Impacts and TreatmentsEffects and risks of endocrine disrupting chemicals

Impaired estrogen receptor action in the pathogenesis of the metabolic syndrome

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Hevener, Andrea L., Clegg, Deborah J., Mauvais-Jarvis, Franck·2015·Molecular and Cellular Endocrinology
DOI 10.1016/j.mce.2015.05.020PMC PMC5965692
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Abstract

Considering the current trends in life expectancy, women in the modern era are challenged with facing menopausal symptoms as well as heightened disease risk associated with increasing adiposity and metabolic dysfunction for up to three decades of life. Treatment strategies to combat metabolic dysfunction and associated pathologies have been hampered by our lack of understanding regarding the biological underpinnings of these clinical conditions and our incomplete understanding of the effects of estrogens and the tissue-specific functions and molecular actions of its receptors. In this review we provide evidence supporting a critical and protective role for the estrogen receptor α specific form in the maintenance of metabolic homeostasis and insulin sensitivity. Studies identifying the ER-regulated pathways required for disease prevention will lay the important foundation for the rational design of targeted therapeutics to improve women's health while limiting complications that have plagued traditional hormone replacement interventions.

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  • Estrogen actions in skeletal muscle, liver, adipose tissue, and immune cells are involved in insulin sensitivity and prevention of lipid accumulation and inflammation.

    “Estrogen actions in skeletal muscle, liver, adipose tissue, and immune cells are involved in insulin sensitivity as well as prevention of lipid accumulation and inflammation [20,21,67,68].”

    From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [68]

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Authors
Hevener, A. L., Clegg, D. J., & Mauvais-Jarvis, F.
Affiliations
  • University of California, Los Angeles (US)
  • Cedars-Sinai Medical Center (US)
Corresponding author
Hevener, Andrea L.
ORCID
Venue
Molecular and Cellular Endocrinology
Publisher
Elsevier BV
Published
2015-12
Volume
418
Pages
306-321
ISSN
0303-7207 (ISSN-L)
DOI
10.1016/j.mce.2015.05.020
PMC
PMC5965692
OpenAlex
W409864959
Cited by
112
References
270
Citations by year
2026: 5 · 2025: 12 · 2024: 11 · 2023: 12 · 2022: 9 · 2021: 6 · 2020: 9 · 2019: 8 · 2018: 17 · 2017: 15 · 2016: 7 · 2015: 1
FWCI
1.69
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Molecular and Cellular Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Institutes of Health (DK89109, DK063491, R01 DK074970)
  • UCLA Department of Medicine
  • UCLA Iris-Cantor Women’s Health Foundation
  • UCLA Jonsson Comprehensive Cancer Center
  • NIDDK (P01 088761-01)
  • Klarman Foundation for Eating Disorders
  • American Diabetes Association (7-13-BS-101)
  • Price-Goldsmith Endowed Chair in Nutrition
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Keywords
estrogen receptor alpha, metabolic syndrome, insulin sensitivity, metabolic homeostasis, menopause, adiposity, metabolic dysfunction, hormone replacement therapy, women's health, targeted therapeutics
MeSH terms
Animals, Energy Metabolism, Female, Homeostasis, Humans, Insulin Resistance, Motor Activity, Organ Specificity, Women's Health, Metabolic Syndrome, Estrogen Receptor alpha

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