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Cited by 296

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

The role of vitamin D in the endocrinology controlling calcium homeostasis

Open access
Fleet, James C.·2017·Molecular and Cellular Endocrinology

Abstract

Vitamin D and its’ metabolites are a crucial part of the endocrine system that controls whole body calcium homeostasis. The goal of this hormonal control is to regulate serum calcium levels so that they are maintained within a very narrow range. To achieve this goal, regulatory events occur in coordination at multiple tissues, e.g. the intestine, kidney, bone, and parathyroid gland. Production of the vitamin D endocrine hormone, 1,25 dihydroxyvitamin D (1,25(OH)2 D) is regulated by habitual dietary calcium intake and physiologic states like growth, aging, and the menopause. The molecular actions of 1,25(OH)2 D on calcium regulating target tissues are mediated predominantly by transcription controlled by the vitamin D receptor. The primary role for 1,25(OH)2 D during growth is to increase intestinal calcium absorption so that sufficient calcium is available for bone mineralization. However, vitamin D also has specific actions on kidney and bone.

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Crossref · 10.1016/j.mce.2017.04.008

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Metadata

Authors
Fleet, J. C.
Venue
Molecular and Cellular Endocrinology
Publisher
Elsevier BV
Published
2017-09
Volume
453
Pages
36-45
ISSN
0303-7207 (ISSN-L)
OpenAlex
W2605046576
Cited by
296
References
6
FWCI
12.42
Type
journal article
Language
en
Open access
green

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