The DOI matches its Crossref record; 75 of the 76 references it cites were found in a registry or an index.
Receptor protein tyrosine phosphatase sigma inhibits axon regrowth in the adult injured CNS
Abstract
Recently, receptor protein tyrosine phosphatase-sigma (RPTPsigma) has been shown to inhibit axon regeneration in injured peripheral nerves. Unlike the peripheral nervous system (PNS), central nervous system (CNS) neurons fail to regenerate their axons after injury or in disease. In order to assess the role of RPTPsigma in CNS regeneration, we used the retinocollicular system of adult mice lacking RPTPsigma to evaluate retinal ganglion cell (RGC) axon regrowth after optic nerve lesion. Quantitative analysis demonstrated a significant increase in the number of RGC axons that crossed the glial scar and extended distally in optic nerves from RPTPsigma (-/-) mice compared to wild-type littermate controls. Although we found that RPTPsigma is expressed by adult RGCs in wild-type mice, the retinas and optic nerves of adult RPTPsigma (-/-) mice showed no histological defects. Furthermore, the time-course of RGC death after nerve lesion was not different between knockout and wild-type animals. Thus, enhanced axon regrowth in the absence of RPTPsigma could not be attributed to developmental defects or increased neuronal survival. Finally, we show constitutively elevated activity of mitogen-activated protein kinase (MAPK) and Akt kinase in adult RPTPsigma (-/-) mice retinas, suggesting that these signaling pathways may contribute to promoting RGC axon regrowth following traumatic nerve injury. Our results support a model in which RPTPsigma inhibits axon regeneration in the adult injured CNS.
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“RPTPσ can bind with high affinity to neurocan and aggrecan and strongly inhibits axon outgrowth and regeneration (Sapieha et al., 2005;Shen et al., 2009;Fry et al., 2010;Lang et al., 2015).”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Sapieha et al., 2005
Citations
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Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth
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Protein tyrosine phosphatases: from genes, to function, to disease
Tonks, N. K. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2039 · Cited by 1,712
PTPσ Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration
Shen, Y., Tenney, A. P., Busch, S. A., Horn, K. P., Cuascut, F. X., Liu, K., He, Z., Silver, J., & Flanagan, J. G. (2009) · Science · doi:10.1126/science.1178310 · Cited by 682
Functional regeneration beyond the glial scar
Cregg, J. M., DePaul, M. A., Filous, A. R., Lang, B. T., Tran, A. P., & Silver, J. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2013.12.024 · Cited by 688
Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury
Lang, B. T., Cregg, J. M., DePaul, M. A., Tran, A. P., Xu, K., Dyck, S. M., Madalena, K. M., Brown, B. P., Weng, Y.-L., Li, S., et al. (2015) · Nature · doi:10.1038/nature13974 · Cited by 465
NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans
Dickendesher, T. L., Baldwin, K. T., Mironova, Y. A., Koriyama, Y., Raiker, S. J., Askew, K. L., Wood, A., Geoffroy, C. G., Zheng, B., Liepmann, C. D., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3070 · Cited by 449
Metadata
- Authors
- Sapieha, P. S., Duplan, L., Uetani, N., Joly, S., Tremblay, M. L., Kennedy, T. E., & Di Polo, A.
- Affiliations
- Université de Montréal (CA)
- McGill University (CA)
- Montreal Neurological Institute and Hospital (CA)
- Venue
- Molecular and Cellular Neuroscience
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 28
- Issue
- 4
- Pages
- 625-635
- ISSN
- 1044-7431 (ISSN-L)
- OpenAlex
- W2092811972
- Cited by
- 106
- References
- 76
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 7 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 10 · 2014: 15 · 2013: 6 · 2012: 10
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Keywords
- axon regeneration, optic nerve injury, retinal ganglion cells, glial scar, mitogen-activated protein kinase, Akt kinase, knockout mice
- MeSH terms
- Animals, Axons, Female, Mice, Inbred BALB C, Nerve Regeneration, Neural Inhibition, Retinal Ganglion Cells, Protein Tyrosine Phosphatases, Mice, Knockout, Optic Nerve Injuries, Mice, Receptor-Like Protein Tyrosine Phosphatases, Class 2
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